Coenzyme A (PAMDB000381)

General function:

Involved in transferase activity, transferring acyl groups

Specific function:

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3)

Gene Name:

aceF

Locus Tag:

PA5016

Molecular weight:

56.7 kDa

Reactions

General function:

Involved in 2-isopropylmalate synthase activity

Specific function:

Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)

Gene Name:

leuA

Locus Tag:

PA3792

Molecular weight:

65.8 kDa

Reactions

General function:

Involved in cellular amino acid biosynthetic process

Specific function:

Acetyl-CoA + L-glutamate = CoA + N-acetyl-L- glutamate

Gene Name:

argA

Locus Tag:

PA5204

Molecular weight:

47.9 kDa

Reactions

General function:

Involved in dephospho-CoA kinase activity

Specific function:

Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A

Gene Name:

coaE

Locus Tag:

PA4529

Molecular weight:

22.8 kDa

Reactions

General function:

Involved in transferase activity, transferring acyl groups

Specific function:

Catalyzes the transfer of an acyl group from acyl-ACP to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme can utilize either acyl-CoA or acyl-ACP as the fatty acyl donor

Gene Name:

plsB

Locus Tag:

PA3673

Molecular weight:

94.8 kDa

Reactions

General function:

Involved in ATP binding

Specific function:

ATP + succinate + CoA = ADP + phosphate + succinyl-CoA

Gene Name:

sucC

Locus Tag:

PA1588

Molecular weight:

41.5 kDa

Reactions

General function:

Involved in phosphatidylserine decarboxylase activity

Specific function:

Phosphatidyl-L-serine = phosphatidylethanolamine + CO(2)

Gene Name:

psd

Locus Tag:

PA4957

Molecular weight:

32 kDa

Reactions

General function:

Involved in transferase activity

Specific function:

Acetyl-CoA + L-serine = CoA + O-acetyl-L- serine

Gene Name:

cysE

Locus Tag:

PA3816

Molecular weight:

27.9 kDa

Reactions

General function:

Involved in 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase activity

Specific function:

Succinyl-CoA + (S)-2,3,4,5-tetrahydropyridine- 2,6-dicarboxylate + H(2)O = CoA + N-succinyl-L-2-amino-6- oxoheptanedioate

Gene Name:

dapD

Locus Tag:

PA3666

Molecular weight:

36 kDa

Reactions

General function:

Involved in phosphate acetyltransferase activity

Specific function:

Acetyl-CoA + phosphate = CoA + acetyl phosphate

Gene Name:

pta

Locus Tag:

PA0835

Molecular weight:

75.7 kDa

Reactions

General function:

Involved in transferase activity

Specific function:

Malonyl-CoA + [acyl-carrier-protein] = CoA + malonyl-[acyl-carrier-protein]

Gene Name:

fabD

Locus Tag:

PA2968

Molecular weight:

32.4 kDa

Reactions

General function:

Involved in transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer

Specific function:

Acetyl-CoA + H(2)O + oxaloacetate = citrate + CoA

Gene Name:

gltA

Locus Tag:

PA1580

Molecular weight:

47.7 kDa

Reactions

General function:

Involved in magnesium ion binding

Specific function:

Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-GlcNAc. Responsible for the acetylation of Glc-N-1-P to give GlcNAc-1-P and for the uridyl transfer from UTP to GlcNAc-1-P which produces UDP-GlcNAc

Gene Name:

glmU

Locus Tag:

PA5552

Molecular weight:

48.9 kDa

Reactions

General function:

Involved in arginine N-succinyltransferase activity

Specific function:

Catalyzes the transfer of succinyl-CoA to arginine to produce N(2)-succinylarginine

Gene Name:

astA

Locus Tag:

PA0897

Molecular weight:

37.2 kDa

Reactions

General function:

Involved in oxoglutarate dehydrogenase (succinyl-transferring) activity

Specific function:

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components:2- oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3)

Gene Name:

sucA

Locus Tag:

PA1585

Molecular weight:

105.9 kDa

Reactions

General function:

Involved in transferase activity, transferring acyl groups

Specific function:

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components:2- oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3)

Gene Name:

sucB

Locus Tag:

PA1586

Molecular weight:

42.9 kDa

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3)

Gene Name:

aceE

Locus Tag:

PA5015

Molecular weight:

99.6 kDa

Reactions

General function:

Involved in catalytic activity

Specific function:

ATP + succinate + CoA = ADP + phosphate + succinyl-CoA

Gene Name:

sucD

Locus Tag:

PA1589

Molecular weight:

30.3 kDa

Reactions

General function:

Involved in transferase activity, transferring acyl groups other than amino-acyl groups

Specific function:

Catalyzes thiolytic cleavage of beta-ketoadipyl-CoA to succinyl-CoA and acetyl-CoA

Gene Name:

paaJ

Locus Tag:

PA0228

Molecular weight:

42.1 kDa

Reactions

General function:

Involved in 8-amino-7-oxononanoate synthase activity

Specific function:

Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A, and carbon dioxide

Gene Name:

bioF

Locus Tag:

PA0501

Molecular weight:

42.2 kDa

Reactions

General function:

Involved in acetyl-CoA C-acyltransferase activity

Specific function:

Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed. Involved in the aerobic and anaerobic degradation of long-chain fatty acids

Gene Name:

fadA

Locus Tag:

PA3013

Molecular weight:

41.6 kDa

Reactions

General function:

Involved in acetate-CoA ligase activity

Specific function:

Enables the cell to use acetate during aerobic growth to generate energy via the TCA cycle, and biosynthetic compounds via the glyoxylate shunt. Acetylates CheY, the response regulator involved in flagellar movement and chemotaxis

Gene Name:

acs

Locus Tag:

PA0887

Molecular weight:

71.8 kDa

Reactions

General function:

Involved in transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer

Specific function:

Catalyzes the synthesis of 2-methylcitrate from propionyl-CoA and oxaloacetate. Also catalyzes the condensation of oxaloacetate with acetyl-CoA but with a lower specificity

Gene Name:

prpC

Locus Tag:

PA0795

Molecular weight:

41.7 kDa

Reactions

General function:

Involved in catalytic activity

Specific function:

Accounts for almost the entire malate-synthesizing activity in cells metabolizing glyoxylate

Gene Name:

glcB

Locus Tag:

PA0482

Molecular weight:

78.7 kDa

Reactions

General function:

Involved in catalytic activity

Specific function:

Catalyzes the esterification, concomitant with transport, of exogenous long-chain fatty acids into metabolically active CoA thioesters for subsequent degradation or incorporation into phospholipids

Gene Name:

fadD

Locus Tag:

PA3299

Molecular weight:

61.7 kDa

Reactions

General function:

Involved in transferase activity, transferring acyl groups other than amino-acyl groups

Specific function:

2 acetyl-CoA = CoA + acetoacetyl-CoA

Gene Name:

atoB

Locus Tag:

PA2001

Molecular weight:

40.4 kDa

Reactions

General function:

Involved in catalytic activity

Specific function:

Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA

Gene Name:

plsX

Locus Tag:

PA2969

Molecular weight:

34.6 kDa

Reactions

General function:

Involved in acyl-CoA hydrolase activity

Specific function:

Can hydrolyze a broad range of acyl-CoA thioesters. Its physiological function is not known

Gene Name:

tesB

Locus Tag:

PA3942

Molecular weight:

32.9 kDa

General function:

Involved in fatty acid biosynthetic process

Specific function:

Carrier of the growing fatty acid chain in fatty acid biosynthesis

Gene Name:

acpP

Locus Tag:

PA2966

Molecular weight:

8.7 kDa

General function:

Not Available

Specific function:

Not Available

Gene Name:

yncA

Locus Tag:

PA4866

Molecular weight:

18.7 kDa