Beta-ketoadipyl-CoA thiolase (PA0228)

Identification
Name: Beta-ketoadipyl-CoA thiolase
Synonyms:
  • 3-oxoadipyl-CoA thiolase
Gene Name: paaJ
Enzyme Class:
Biological Properties
General Function: Involved in transferase activity, transferring acyl groups other than amino-acyl groups
Specific Function: Catalyzes thiolytic cleavage of beta-ketoadipyl-CoA to succinyl-CoA and acetyl-CoA
Cellular Location: Not Available
KEGG Pathways:
  • Benzoate degradation via hydroxylation pae00362
  • Microbial metabolism in diverse environments pae01120
  • Phenylalanine metabolism pae00360
KEGG Reactions:
Thumb+Thumb ↔ Thumb+Thumb
3-Oxo-5,6-dehydrosuberyl-CoA + Coenzyme A ↔ 5-Carboxy-2-pentenoyl-CoA + Acetyl-CoA
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Thumb+Thumb ↔ Thumb+Thumb
Coenzyme A + 3-Oxoadipyl-CoA ↔ Acetyl-CoA + Succinyl-CoA
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Thumb+Thumb ↔ Thumb+Thumb
Succinyl-CoA + Acetyl-CoA ↔ Coenzyme A + 3-Oxoadipyl-CoA
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Thumb+Thumb ↔ Thumb+Thumb
3-Oxo-5,6-dehydrosuberyl-CoA + Coenzyme A ↔ 5-Carboxy-2-pentenoyl-CoA + Acetyl-CoA
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SMPDB Reactions:
Thumb+Thumb → Thumb+2,3-didehydroadipyl-CoA
3-Oxo-5,6-dehydrosuberyl-CoA + Coenzyme A → Acetyl-CoA + 2,3-didehydroadipyl-CoA
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3-Oxoadipyl-CoA+Thumb → Thumb+Thumb
3-Oxoadipyl-CoA + Coenzyme A → Acetyl-CoA + Succinyl-CoA
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PseudoCyc/BioCyc Reactions:
Thumb+Thumb ↔ Thumb+Thumb
Coenzyme A + 3-Oxoadipyl-CoA ↔ Acetyl-CoA + Succinyl-CoA
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Thumb+Thumb ← Thumb+Thumb
Succinyl-CoA + Acetyl-CoA ← 3-Oxoadipyl-CoA + Coenzyme A
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Thumb+Thumb → 2,3-dehydroadipyl-CoA+Thumb
3-Oxo-5,6-dehydrosuberyl-CoA + Coenzyme A → 2,3-dehydroadipyl-CoA + Acetyl-CoA
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Complex Reactions: Not Available
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB0035532,3-dehydroadipyl-CoAMetaboCard
PAMDB0015813-Oxo-5,6-dehydrosuberyl-CoAMetaboCard
PAMDB0009263-Oxoadipyl-CoAMetaboCard
PAMDB0009495-Carboxy-2-pentenoyl-CoAMetaboCard
PAMDB000298Acetyl-CoAMetaboCard
PAMDB000381Coenzyme AMetaboCard
PAMDB000228Succinyl-CoAMetaboCard
GO Classification:
Function
catalytic activity
transferase activity
transferase activity, transferring acyl groups
transferase activity, transferring acyl groups other than amino-acyl groups
Process
catechol catabolic process
catechol metabolic process
cellular aromatic compound metabolic process
cellular metabolic process
metabolic process
phenol metabolic process
protocatechuate catabolic process
Gene Properties
Locus tag: PA0228
Strand: +
Entrez Gene ID: 877715
Accession: NP_248919.1
GI: 15595425
Sequence start: 257108
Sequence End: 258313
Sequence Length: 1205
Gene Sequence: 
>PA0228
ATGAGCCGCGAGGTATTCATCTGCGATGCCGTGCGCACGCCGATCGGCCGTTTCGGCGGCAGTCTTTCCGCGGTGCGCGCCGACGACCTCGCGGCGGTGCCGCTGAAGGCCCTGGTCGAGCGCAACCCGGGGGTCGACTGGTCGGCGTTGGACGAGGTGTTCCTCGGCTGCGCCAACCAGGCCGGCGAGGACAACCGTAACGTGGCGCGCATGGCGCTGCTGCTGGCCGGTTTGCCGGAGAGCGTGCCCGGCGTCACCCTCAACCGCCTCTGCGCCTCGGGGATGGACGCCATCGGCACGGCGTTCCGCGCCATCGCCTGCGGCGAGATGGAGCTGGCCATCGCCGGCGGCGTCGAGTCGATGTCGCGCGCGCCGTACGTGATGGGCAAGGCCGATAGCGCCTTCGGTCGCGGCCAGAAGATCGAGGACACCACCATCGGCTGGCGCTTCGTCAATCCGCTGATGAAGGAGCAGTACGGCATCGACCCGATGCCGCAGACCGCCGACAACGTCGCCGACGACTATCGCGTGTCGCGTGCCGACCAGGATGCCTTCGCCCTGCGCAGCCAGCAGCGCGCCGGCAGGGCGCAGGAGGCCGGTTTCTTCGCCGAGGAAATCGTCCCGGTGACGATTCGCGGGCGCAAGGGCGACACCCTGGTCGAGCACGACGAGCATCCGCGTCCCGACACCACCCTGGAGGCGCTGGCCCGGCTCAAGCCGGTCAACGGGCCGGAGAAGACCGTCACCGCCGGCAACGCGTCCGGGGTCAACGACGGCGCCGCCGCGCTGGTCCTGGCCTCCGCCGAGGCAGTGGAGAAGCACGGCCTGACTCCGCGCGCGCGGGTGCTGGGCATGGCCAGCGCCGGCGTCGCCCCACGGATCATGGGCATCGGCCCGGTGCCGGCGGTGCGCAAGCTGCTGCGGCGCCTGGACCTGGCGATCGACGCCTTCGACGTGATCGAACTCAACGAAGCCTTCGCCAGCCAGGGCCTGGCCTGCCTGCGCGAACTGGGCGTGGCCGACGACAGTGAGAAGGTCAACCCGAACGGCGGTGCCATCGCCCTCGGCCACCCGCTGGGGATGAGCGGTGCGCGGCTGGTCCTCACCGCGCTCCATCAACTTGAGAAGAGCGGCGGCCGGCGCGGCCTGGCGACCATGTGCGTAGGCGTCGGCCAAGGCCTGGCGCTGGCCATCGAGCGGGTCTGA
Protein Properties
Protein Residues: 401
Protein Molecular Weight: 42.1 kDa
Protein Theoretical pI: 5.52
Hydropathicity (GRAVY score): 0.007
Charge at pH 7 (predicted): -4.96
Protein Sequence: 
>PA0228
MSREVFICDAVRTPIGRFGGSLSAVRADDLAAVPLKALVERNPGVDWSALDEVFLGCANQAGEDNRNVARMALLLAGLPESVPGVTLNRLCASGMDAIGTAFRAIACGEMELAIAGGVESMSRAPYVMGKADSAFGRGQKIEDTTIGWRFVNPLMKEQYGIDPMPQTADNVADDYRVSRADQDAFALRSQQRAGRAQEAGFFAEEIVPVTIRGRKGDTLVEHDEHPRPDTTLEALARLKPVNGPEKTVTAGNASGVNDGAAALVLASAEAVEKHGLTPRARVLGMASAGVAPRIMGIGPVPAVRKLLRRLDLAIDAFDVIELNEAFASQGLACLRELGVADDSEKVNPNGGAIALGHPLGMSGARLVLTALHQLEKSGGRRGLATMCVGVGQGLALAIERV
References
External Links:
Resource Link
Genome ID: PA0228
Entrez Gene ID: 877715
NCBI Protein ID: 15595425
General Reference: PaperBLAST - Find papers about PA0228 and its homologs