Acetyl-coenzyme A synthetase (PA0887)

Identification
Name: Acetyl-coenzyme A synthetase
Synonyms:
  • Acetate--CoA ligase
  • Acyl-activating enzyme
Gene Name: acs
Enzyme Class:
Biological Properties
General Function: Involved in acetate-CoA ligase activity
Specific Function: Enables the cell to use acetate during aerobic growth to generate energy via the TCA cycle, and biosynthetic compounds via the glyoxylate shunt. Acetylates CheY, the response regulator involved in flagellar movement and chemotaxis
Cellular Location: Cytoplasm
KEGG Pathways:
KEGG Reactions:
Thumb+Thumb+Thumb ↔ Thumb+Thumb+Thumb
Acetic acid + Adenosine triphosphate + Coenzyme A ↔ Acetyl-CoA + Adenosine monophosphate + Pyrophosphate
ReactionCard
Thumb+Thumb+Thumb ↔ Thumb+Thumb+Thumb
Adenosine triphosphate + Acetic acid + Coenzyme A ↔ Adenosine monophosphate + Pyrophosphate + Acetyl-CoA
ReactionCard
Thumb+Thumb+Thumb → Thumb+Thumb+Thumb
Coenzyme A + Acetic acid + Adenosine triphosphate → Acetyl-CoA + Pyrophosphate + Adenosine monophosphate
ReactionCard
SMPDB Reactions:
Thumb+Thumb+Thumb → Propionyl-CoA+Thumb+Pyrophosphate+Thumb
Propionic acid + Adenosine triphosphate + Coenzyme A → Propionyl-CoA + Adenosine monophosphate + Pyrophosphate + Propionyl-CoA
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Thumb+Thumb+Thumb → Pyrophosphate+Thumb+Thumb
Acetic acid + Adenosine triphosphate + Coenzyme A → Pyrophosphate + Adenosine monophosphate + Acetyl-CoA
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PseudoCyc/BioCyc Reactions:
Thumb+Thumb+Thumb ↔ Thumb+Thumb+Thumb
Acetic acid + Adenosine triphosphate + Coenzyme A ↔ Acetyl-CoA + Adenosine monophosphate + Pyrophosphate
ReactionCard
Thumb+Thumb+Thumb → Thumb+Thumb+Thumb
Coenzyme A + Acetic acid + Adenosine triphosphate → Acetyl-CoA + Pyrophosphate + Adenosine monophosphate
ReactionCard
Thumb+Thumb+Thumb → Thumb+Thumb+Thumb
Coenzyme A + Propionic acid + Adenosine triphosphate → Propionyl-CoA + Pyrophosphate + Adenosine monophosphate
ReactionCard
Complex Reactions:
Thumb+Thumb+Thumb → Thumb+Thumb+Thumb
Adenosine triphosphate + Coenzyme A + Propionic acid → ADP + Phosphate + Propionyl-CoA
ReactionCard
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB000012Acetic acidMetaboCard
PAMDB000298Acetyl-CoAMetaboCard
PAMDB000014Adenosine monophosphateMetaboCard
PAMDB001828Adenosine tetraphosphateMetaboCard
PAMDB000148Adenosine triphosphateMetaboCard
PAMDB000345ADPMetaboCard
PAMDB000381Coenzyme AMetaboCard
PAMDB000383PhosphateMetaboCard
PAMDB000098Propionic acidMetaboCard
PAMDB000321Propionyl-CoAMetaboCard
PAMDB000633PyrophosphateMetaboCard
GO Classification:
Function
acetate-CoA ligase activity
adenyl nucleotide binding
adenyl ribonucleotide binding
AMP binding
binding
catalytic activity
CoA-ligase activity
ligase activity
ligase activity, forming carbon-sulfur bonds
nucleoside binding
purine nucleoside binding
Process
metabolic process
Gene Properties
Locus tag: PA0887
Strand: +
Entrez Gene ID: 879732
Accession: NP_249578.1
GI: 15596084
Sequence start: 969670
Sequence End: 971625
Sequence Length: 1955
Gene Sequence: 
>PA0887
ATGTCTGCGGCATCCCTGTACCCCGTGCACCCGGAAGCGGTGGCACGGACCTTCACCGACGAAGCCACCTACAAGACGATGTACCAGCAGTCCGTCGTCAACCCCGACGGCTTCTGGCGCGAGCAGGCCCAGCGGATCGACTGGATCAAGCCGTTCGAGAAGGTCAAGCAGACCTCCTTCGACGACCATCACGTGGACATCAAGTGGTTCGCCGACGGCACCCTCAACGTGTCGCACAACTGCCTCGACCGTCACCTCGCCGAACGCGGCGACCAGGTGGCGATCATCTGGGAAGGCGACGATCCCGCCGACCACCAGGAAATCACCTACCGCCAGCTCCACGAGCAGGTCTGCAAGTTCGCCAACGCCCTGCGCGGGCAGGACGTGCACCGCGGCGACGTAGTGACCATCTACATGCCGATGATCCCCGAGGCCGTGGTCGCCATGCTCGCCTGCACCCGCATCGGCGCGATCCACTCGGTGGTCTTCGGCGGCTTCTCCCCCGAGGCCCTGGCAGGACGCATCATCGATTGCAAGTCGAAGGTGGTGATCACCGCCGACGAAGGCGTGCGCGGCGGCAAGCGCACTCCGCTGAAGGCCAATGTCGACGACGCCCTGACCAACCCGGAAACCTCCAGCGTGCAGAAGATCATCGTCTGCAAGCGTACCGGTGCGGAGATCAAGTGGAACCAGCACCGCGACGTCTGGTACGACGACCTGATGAAGGTTGCCGGCAGCACTTGCGCACCCAAGGAAATGGGCGCCGAGGACCCGCTGTTCATCCTCTACACCTCCGGCTCCACCGGCAAGCCGAAGGGCGTGCTGCATACCACCGGCGGCTACCTGGTGTACGCCTCGCTGACCCACGAGCGGGTCTTCGACTACCGTCCGGGCGAAGTCTACTGGTGCACCGCCGACATCGGCTGGGTCACCGGCCACACCTACATCGTCTATGGCCCGTTGGCCAACGGCGCCACCACCATTCTGTTCGAGGGCGTGCCGAACTACCCCGACGTGACCCGCGTGGCGAAAATCATCGACAAGCACAAGGTCAACATCCTCTACACCGCGCCGACCGCGATCCGCGCGATGATGGCCGAAGGCAAGGCGGCGGTGGCCGGTGCCGACGGTTCCAGCCTGCGTCTGCTCGGTTCGGTGGGCGAGCCGATCAACCCGGAAGCCTGGCAGTGGTACTACGAGACCGTCGGCCAGTCGCGCTGCCCGATCGTCGACACCTGGTGGCAGACCGAGACCGGCGCCTGCCTGATGACCCCGCTGCCGGGCGCCCACGCGATGAAGCCGGGCTCTGCAGCCAAGCCGTTCTTCGGCGTGGTACCGGCGCTGGTGGACAACCTCGGCAACCTGATCGAGGGCGCCGCCGAGGGCAACCTGGTGATCCTCGACTCCTGGCCGGGCCAGGCGCGGACCCTGTTCGGCGACCATGACCGCTTCGTCGACACCTACTTCAAGACCTTCAAGGGCATGTACTTCACCGGCGACGGCGCGCGCCGCGACGAGGACGGCTACTACTGGATCACCGGGCGGGTCGACGACGTGCTCAACGTCTCCGGCCACCGCATGGGCACCGCCGAGGTGGAAAGCGCGATGGTCGCCCACCCGAAGGTCGCCGAGGCGGCGGTGGTCGGCATGCAGCACGACATCAAGGGGCAGGGCATCTATGTCTACGTCACCCTCAACTCCGGGGTCGAGCCGAGCGAGGCGCTGCGCCAGGAGCTGAAGCAATGGGTTCGCCGCGAGATCGGTCCGATCGCCACGCCGGATGTGATCCAGTGGGCGCCGGGACTGCCGAAGACCCGTTCGGGCAAGATCATGCGGCGCATCCTGCGCAAGATCGCCGCGGCCGAGTACGACACCCTCGGCGACATCTCCACCCTTGCCGACCCGGGCGTGGTCCAGCACCTGATCGAGACCCATCGCTCGATGCAGGCCGCCTGA
Protein Properties
Protein Residues: 651
Protein Molecular Weight: 71.8 kDa
Protein Theoretical pI: 6.32
Hydropathicity (GRAVY score): -0.214
Charge at pH 7 (predicted): -8.2
Protein Sequence: 
>PA0887
MSAASLYPVHPEAVARTFTDEATYKTMYQQSVVNPDGFWREQAQRIDWIKPFEKVKQTSFDDHHVDIKWFADGTLNVSHNCLDRHLAERGDQVAIIWEGDDPADHQEITYRQLHEQVCKFANALRGQDVHRGDVVTIYMPMIPEAVVAMLACTRIGAIHSVVFGGFSPEALAGRIIDCKSKVVITADEGVRGGKRTPLKANVDDALTNPETSSVQKIIVCKRTGAEIKWNQHRDVWYDDLMKVAGSTCAPKEMGAEDPLFILYTSGSTGKPKGVLHTTGGYLVYASLTHERVFDYRPGEVYWCTADIGWVTGHTYIVYGPLANGATTILFEGVPNYPDVTRVAKIIDKHKVNILYTAPTAIRAMMAEGKAAVAGADGSSLRLLGSVGEPINPEAWQWYYETVGQSRCPIVDTWWQTETGACLMTPLPGAHAMKPGSAAKPFFGVVPALVDNLGNLIEGAAEGNLVILDSWPGQARTLFGDHDRFVDTYFKTFKGMYFTGDGARRDEDGYYWITGRVDDVLNVSGHRMGTAEVESAMVAHPKVAEAAVVGMQHDIKGQGIYVYVTLNSGVEPSEALRQELKQWVRREIGPIATPDVIQWAPGLPKTRSGKIMRRILRKIAAAEYDTLGDISTLADPGVVQHLIETHRSMQAA
References
External Links:
Resource Link
Genome ID: PA0887
Entrez Gene ID: 879732
NCBI Protein ID: 15596084
General Reference: PaperBLAST - Find papers about PA0887 and its homologs