| Identification |
| Name: |
8-amino-7-oxononanoate synthase |
| Synonyms: |
- AONS
- 7-keto-8-amino-pelargonic acid synthase
- 7-KAP synthase
- KAPA synthase
- 8-amino-7-ketopelargonate synthase
- L-alanine--pimeloyl-CoA ligase
|
| Gene Name: |
bioF |
| Enzyme Class: |
|
| Biological Properties |
| General Function: |
Involved in 8-amino-7-oxononanoate synthase activity |
| Specific Function: |
Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A, and carbon dioxide |
| Cellular Location: |
Not Available |
| KEGG Pathways: |
|
| KEGG Reactions: |
|
6-Carboxyhexanoyl-CoA | + |  | + |  | ↔ |  | + |  | + |  | + | Acyl-carrier protein |
| |
|
| SMPDB Reactions: |
|
a pimeloyl-[acp] | + | L-Alanine | + | | → | | + | a holo-[acyl-carrier protein] | + | |
| | | |
|
| PseudoCyc/BioCyc Reactions: |
|
| Complex Reactions: |
|
| + | Pimeloyl-[acyl-carrier protein] | → | | + | acyl carrier protein | + | |
| |
|
| Transports: |
Not Available |
| Metabolites: |
|
| GO Classification: |
| Function |
|---|
| 8-amino-7-oxononanoate synthase activity | | binding | | catalytic activity | | cofactor binding | | pyridoxal phosphate binding | | transferase activity | | transferase activity, transferring acyl groups | | transferase activity, transferring acyl groups other than amino-acyl groups | | transferase activity, transferring nitrogenous groups | | Process |
|---|
| biosynthetic process | | biotin biosynthetic process | | biotin metabolic process | | metabolic process | | small molecule metabolic process | | vitamin metabolic process | | water-soluble vitamin metabolic process |
|
| Gene Properties |
| Locus tag: |
PA0501 |
| Strand: |
+ |
| Entrez Gene ID: |
879619 |
| Accession: |
NP_249192.1 |
| GI: |
15595698 |
| Sequence start: |
560808 |
| Sequence End: |
562013 |
| Sequence Length: |
1205 |
| Gene Sequence: |
>PA0501
ATGTCCTTCGATCTCGCTTCCCGCCTCGCCAGCCGGCGCGCGGAAGACCTCTACCGCCAGCGGCCGCTGCTGGAGTCGGCCCAGGGCCCGGACGTCGTGGTCGACGGCCAGCCGCTGCTGGCCTTCTGTTCCAACGACTACCTCGGCCTGGCCAACCATCCCGAGGTGATCGCCGCGCTGCGCGCCGGCGCCGAGCGCTGGGGCGTGGGCGGTGGCGCCTCGCACCTGGTGGTCGGCCACAGCGGCCCGCACCACGAACTGGAGCTGGCCCTCGCCGAATTCACCGGGCGGCCGCGCGCGCTGCTGTTCTCCACCGGCTACATGGCCAATCTCGGCGCGGTGGCCGCGCTGGTCGGCAAGGGCGACACGGTGCTGGAGGACCGCCTCAACCACGCTTCGCTGCTGGATGCCGGATTGCTCTCCGGCGCGCGTTTCTCGCGCTACCTGCACAACGACCCGGCAAGCCTCGCCGCGCGCCTGGACAAGGCCGAGGGCAATACCCTGGTGGTCACCGACGGGGTCTTCAGCATGGACGGCAATCTCGCCGACCTGCCGGCCCTGGCCGCCGTCGCGCAGGCCCGCGGCGCCTGGCTGATGGTCGACGACGCGCATGGCTTCGGCCCGCTGGGCGCCAGCGGCGGCGGGATCGTCGAACACTTCGGCCTCGGCCAGGAGCAGGTGCCGGTGCTGATCGGCACCCTCGGCAAGGGTTTCGGTACCGCCGGCGCCTTCGTAGCGGGCAGCGAGGAACTGATCGAGACCCTGATCCAGTACGCCCGGCCCTACATCTACACCACCAGCCAGCCGCCAGCGGTGGCCTGCGCCACCCTGAAGAGCCTGGAGCTGCTGCGCCGCGAAAGCTGGCGGCGGCAACACCTGGCGGCGCTGATCGCCCGTTTCCGCCATGGCGCCGAGGCGCTTGGCCTGACCCTGATGGACAGCTTCACGCCGATCCAGCCGATCCTGGTCGGCGGCAGCCGCCAGGCCGTGGCCCTGGCCGGCATGCTTCGAGCCCGTGGCATCATGGTCGGCGCGATCCGCCCGCCAACCGTGCCGGCCAACAGCGCGCGGCTGCGCGTCACGCTGTCCGCCGCGCACAGCGAAGCGCAGGTCGACCGCTTGCTCGAAGCCCTCGGCGAAAGCTGGCGACAGCTGTCGTCTAGCCTTCTGGCAGAGATCGAAGCCGAGGAGGGAGACGATGCGTGA |
| Protein Properties |
| Protein Residues: |
401 |
| Protein Molecular Weight: |
42.2 kDa |
| Protein Theoretical pI: |
5.93 |
| Hydropathicity (GRAVY score): |
0.109 |
| Charge at pH 7 (predicted): |
-7.16 |
| Protein Sequence: |
>PA0501
MSFDLASRLASRRAEDLYRQRPLLESAQGPDVVVDGQPLLAFCSNDYLGLANHPEVIAALRAGAERWGVGGGASHLVVGHSGPHHELELALAEFTGRPRALLFSTGYMANLGAVAALVGKGDTVLEDRLNHASLLDAGLLSGARFSRYLHNDPASLAARLDKAEGNTLVVTDGVFSMDGNLADLPALAAVAQARGAWLMVDDAHGFGPLGASGGGIVEHFGLGQEQVPVLIGTLGKGFGTAGAFVAGSEELIETLIQYARPYIYTTSQPPAVACATLKSLELLRRESWRRQHLAALIARFRHGAEALGLTLMDSFTPIQPILVGGSRQAVALAGMLRARGIMVGAIRPPTVPANSARLRVTLSAAHSEAQVDRLLEALGESWRQLSSSLLAEIEAEEGDDA |
| References |
| External Links: |
|
| General Reference: |
PaperBLAST - Find papers about PA0501 and its homologs
|
