Identification |
Name: |
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex |
Synonyms: |
- 2-oxoglutarate dehydrogenase complex component E2
- OGDC-E2
- Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex
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Gene Name: |
sucB |
Enzyme Class: |
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Biological Properties |
General Function: |
Involved in transferase activity, transferring acyl groups |
Specific Function: |
The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components:2- oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) |
Cellular Location: |
Not Available |
KEGG Pathways: |
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KEGG Reactions: |
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| + | Enzyme N6-(dihydrolipoyl)lysine | + | | ↔ | | + | [Dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine |
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| + | Enzyme N6-(dihydrolipoyl)lysine | ↔ | | + | [Dihydrolipoyllysine-residue succinyltransferase] S-glutaryldihydrolipoyllysine |
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SMPDB Reactions: |
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a [2-oxoglutarate dehydrogenase E2 protein] N6-S-succinyldihydrolipoyl-L-lysine | + | | → | a [2-oxoglutarate dehydrogenase E2 protein] N6-dihydrolipoyl-L-lysine | + | |
| a [2-oxoglutarate dehydrogenase E2 protein] N6-S-succinyldihydrolipoyl-L-lysine + Succinyl-CoA → a [2-oxoglutarate dehydrogenase E2 protein] N6-dihydrolipoyl-L-lysine + Coenzyme AReactionCard |
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PseudoCyc/BioCyc Reactions: |
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| + | Enzyme N6-(dihydrolipoyl)lysine | + | | ↔ | | + | [Dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine |
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| + | Enzyme N6-(dihydrolipoyl)lysine | ↔ | | + | [Dihydrolipoyllysine-residue succinyltransferase] S-glutaryldihydrolipoyllysine |
| | | | | glycine + a tetrahydrofolate + NAD + → a 5,10-methylene-tetrahydrofolate + ammonium + CO 2 + NADH ReactionCard | | pyruvate + coenzyme A + NAD + → acetyl-CoA + CO 2 + NADH ReactionCard | | pyruvate + lipoamide → S-acetyldihydrolipoamide + CO 2ReactionCard | | acetyl-CoA + dihydrolipoamide ← S-acetyldihydrolipoamide + coenzyme A ReactionCard | | 2-oxoglutarate + coenzyme A + NAD + → succinyl-CoA + CO 2 + NADH ReactionCard | | a [glycine-cleavage complex H protein] N6-aminomethyldihydrolipoyl-L-lysine + a tetrahydrofolate ↔ a [glycine-cleavage complex H protein] N6-dihydrolipoyl-L-lysine + a 5,10-methylene-tetrahydrofolate + ammonium ReactionCard | | glycine + a [glycine-cleavage complex H protein] N6-lipoyl-L-lysine + H + ↔ a [glycine-cleavage complex H protein] N6-aminomethyldihydrolipoyl-L-lysine + CO 2ReactionCard | | succinyl-lipoate + coenzyme A → succinyl-CoA + DIHYDROLIPOYL-OXO-GLUT-E2 ReactionCard | | a [lipoyl-carrier protein] N6-dihydrolipoyl-L-lysine + NAD + = a [lipoyl-carrier protein]- N6-lipoyl-L-lysine + NADH + H +ReactionCard | | 2-oxoglutarate + a [2-oxoglutarate dehydrogenase E2 protein] N6-lipoyl-L-lysine + H + → a [2-oxoglutarate dehydrogenase E2 protein] N6- S-succinyldihydrolipoyl-L-lysine + CO 2ReactionCard |
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Complex Reactions: |
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Transports: |
Not Available |
Metabolites: |
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GO Classification: |
Component |
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macromolecular complex | oxoglutarate dehydrogenase complex | protein complex | Function |
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acyltransferase activity | binding | catalytic activity | dihydrolipoyllysine-residue succinyltransferase activity | protein binding | S-acyltransferase activity | S-succinyltransferase activity | transferase activity | transferase activity, transferring acyl groups | transferase activity, transferring acyl groups other than amino-acyl groups | Process |
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acetyl-CoA catabolic process | acetyl-CoA metabolic process | cellular metabolic process | coenzyme metabolic process | cofactor metabolic process | metabolic process | tricarboxylic acid cycle |
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Gene Properties |
Locus tag: |
PA1586 |
Strand: |
+ |
Entrez Gene ID: |
881930 |
Accession: |
NP_250277.1 |
GI: |
15596783 |
Sequence start: |
1727118 |
Sequence End: |
1728347 |
Sequence Length: |
1229 |
Gene Sequence: |
>PA1586
ATGGCTATCGAAATCAAAGCCCCAACCTTCCCGGAATCGGTCGCCGACGGCACCGTCGCCACCTGGCACAAGAAGCCGGGCGAAGCAGTCAAGCGCGACGAACTGATCGTCGACATCGAGACCGACAAGGTGGTCATCGAGGTTCTCGCCGAGGCTGACGGCGTGCTGGCCGAGATCATCAAGAACGAAGGCGACACCGTTCTGAGCAACGAGCTGCTCGGCAAGCTGAACGAAGGCGGCGCCGCCGCTCCGGCCGCTCCGGCTGCCGCTGCGCCCGCCGCCGCTCCGGCTGCACAGGCCGCCGCTCCGGCCGCCGCTGGCGGCGACGACGCCATCCTGTCCCCGGCCGCGCGCAAGCTGGCCGAGGAGGCCGGCATCGATCCGAACAGCATCGCCGGCACCGGCAAGGGCGGTCGCGTGACCAAGGAAGACGTGGTCGCTGCGGTCGAAGCGAAGAAGAACGCCCCGGCCGCCCCGGCCAAGCCTGCCGCCCCGGCTGCCGAGGCGCCGATCTTCGCCGCCGGCGACCGTGTCGAGAAGCGCGTGCCGATGACCCGCCTGCGGGCCAAGGTCGCCGAGCGCCTGGTCGAGGCGCAGTCCGCCATGGCCATGCTGACCACCTTCAACGAGGTCAACATGAAGCCGATCATGGACCTGCGTTCGAAGTACAAGGACCTGTTCGAGAAGAAGCACAACGGCGTGCGCCTGGGCTTCATGTCCTTCTTCGTCAAGGCCGCCACCGAGGCGCTGAAGCGCTTCCCGGGGGTCAACGCTTCCATCGACGGCAACGACATCGTCTACCACGGCTACCAGGACATCGGCGTTGCCGTTTCCAGCGACCGCGGCCTGGTGGTTCCGGTACTGCGTAACGCCGAGTTCATGAGCCTGGCCGAGATCGAGGGCGGCATCGCCAACTTCGGCAAGAAGGCGAAGGAAGGCAAGCTGACCATCGAAGACATGACCGGCGGCACCTTCACCATCTCCAACGGTGGCGTGTTCGGTTCCCTGCTGTCGACCCCGATCGTCAACCCGCCGCAGACCGCCATCCTCGGCATGCACAAGATCCAGGAGCGCCCGATGGCCGTGAACGGCCAGGTGGTGATCCTGCCGATGATGTATCTGGCGCTGTCCTACGACCACCGTCTGATCGACGGCAAGGAAGCGGTGAGCTTCCTGGTGGCGATCAAGGACCTGCTGGAAGATCCGGCTCGCCTGCTGCTGGACGTCTGA |
Protein Properties |
Protein Residues: |
409 |
Protein Molecular Weight: |
42.9 kDa |
Protein Theoretical pI: |
5.21 |
Hydropathicity (GRAVY score): |
0.055 |
Charge at pH 7 (predicted): |
-6.78 |
Protein Sequence: |
>PA1586
MAIEIKAPTFPESVADGTVATWHKKPGEAVKRDELIVDIETDKVVIEVLAEADGVLAEIIKNEGDTVLSNELLGKLNEGGAAAPAAPAAAAPAAAPAAQAAAPAAAGGDDAILSPAARKLAEEAGIDPNSIAGTGKGGRVTKEDVVAAVEAKKNAPAAPAKPAAPAAEAPIFAAGDRVEKRVPMTRLRAKVAERLVEAQSAMAMLTTFNEVNMKPIMDLRSKYKDLFEKKHNGVRLGFMSFFVKAATEALKRFPGVNASIDGNDIVYHGYQDIGVAVSSDRGLVVPVLRNAEFMSLAEIEGGIANFGKKAKEGKLTIEDMTGGTFTISNGGVFGSLLSTPIVNPPQTAILGMHKIQERPMAVNGQVVILPMMYLALSYDHRLIDGKEAVSFLVAIKDLLEDPARLLLDV |
References |
External Links: |
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General Reference: |
PaperBLAST - Find papers about PA1586 and its homologs
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