Uridine triphosphate (PAMDB000117)

General function:

Involved in nucleoside diphosphate kinase activity

Specific function:

Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate

Gene Name:

ndk

Locus Tag:

PA3807

Molecular weight:

15.6 kDa

Reactions

General function:

Involved in CTP synthase activity

Specific function:

Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen

Gene Name:

pyrG

Locus Tag:

PA3637

Molecular weight:

59.6 kDa

Reactions

General function:

Involved in DNA-directed RNA polymerase activity

Specific function:

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit plays an important role in subunit assembly since its dimerization is the first step in the sequential assembly of subunits to form the holoenzyme

Gene Name:

rpoA

Locus Tag:

PA4238

Molecular weight:

36.6 kDa

Reactions

General function:

Involved in DNA-directed RNA polymerase activity

Specific function:

Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits

Gene Name:

rpoZ

Locus Tag:

PA5337

Molecular weight:

9.8 kDa

Reactions

General function:

Involved in DNA binding

Specific function:

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates

Gene Name:

rpoC

Locus Tag:

PA4269

Molecular weight:

154.4 kDa

Reactions

General function:

Involved in DNA binding

Specific function:

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates

Gene Name:

rpoB

Locus Tag:

PA4270

Molecular weight:

150.8 kDa

Reactions

General function:

Involved in [formate-C-acetyltransferase]-activating enzyme activity

Specific function:

Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine

Gene Name:

nrdG

Locus Tag:

PA1919

Molecular weight:

25.7 kDa

General function:

Involved in magnesium ion binding

Specific function:

Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-GlcNAc. Responsible for the acetylation of Glc-N-1-P to give GlcNAc-1-P and for the uridyl transfer from UTP to GlcNAc-1-P which produces UDP-GlcNAc

Gene Name:

glmU

Locus Tag:

PA5552

Molecular weight:

48.9 kDa

Reactions

General function:

Involved in UTP:glucose-1-phosphate uridylyltransferase activity

Specific function:

May play a role in stationary phase survival

Gene Name:

galU

Locus Tag:

PA2023

Molecular weight:

31.2 kDa

Reactions

General function:

Involved in nucleoside-triphosphate diphosphatase activity

Specific function:

Specific function unknown

Gene Name:

mazG

Locus Tag:

PA0935

Molecular weight:

31.2 kDa

Reactions

General function:

Involved in amino acid binding

Specific function:

Modifies, by uridylylation or deuridylylation the PII (glnB) regulatory protein

Gene Name:

glnD

Locus Tag:

PA3658

Molecular weight:

103.4 kDa

Reactions

General function:

Involved in catalytic activity

Specific function:

2'-deoxyribonucleoside triphosphate + thioredoxin disulfide + H(2)O = ribonucleoside triphosphate + thioredoxin

Gene Name:

nrdD

Locus Tag:

PA1920

Molecular weight:

76.1 kDa

Reactions

General function:

Involved in hydrolase activity

Specific function:

Hydrolyzes O6 atom-containing purine bases deoxyinosine triphosphate (dITP) and xanthosine triphosphate (XTP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) to nucleotide monophosphate and pyrophosphate. Probably excludes non- standard purines from DNA precursor pool, preventing thus incorporation into DNA and avoiding chromosomal lesions

Gene Name:

rdgB

Locus Tag:

PA0387

Molecular weight:

21.2 kDa

Reactions

General function:

Involved in ATP binding

Specific function:

Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth

Gene Name:

adk

Locus Tag:

PA3686

Molecular weight:

23.1 kDa

Reactions