Anaerobic ribonucleoside-triphosphate reductase (PA1920)

Identification
Name: Anaerobic ribonucleoside-triphosphate reductase
Synonyms: Not Available
Gene Name: nrdD
Enzyme Class:
Biological Properties
General Function: Involved in catalytic activity
Specific Function: 2'-deoxyribonucleoside triphosphate + thioredoxin disulfide + H(2)O = ribonucleoside triphosphate + thioredoxin
Cellular Location: Not Available
KEGG Pathways:
KEGG Reactions:
Thumb+Thioredoxin disulfide+Thumb ↔ Thumb+Thioredoxin
dATP + Thioredoxin disulfide + Water ↔ Adenosine triphosphate + Thioredoxin
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Thumb+Thioredoxin disulfide+Thumb ↔ Thumb+Thioredoxin
dGTP + Thioredoxin disulfide + Water ↔ Guanosine triphosphate + Thioredoxin
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Thumb+Thioredoxin disulfide+Thumb ↔ Thumb+Thioredoxin
dCTP + Thioredoxin disulfide + Water ↔ Cytidine triphosphate + Thioredoxin
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Thumb+Thioredoxin disulfide+Thumb ↔ Thumb+Thioredoxin
Deoxyuridine triphosphate + Thioredoxin disulfide + Water ↔ Uridine triphosphate + Thioredoxin
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2'-Deoxyribonucleoside triphosphate+Thioredoxin disulfide+Thumb ↔ Ribonucleoside triphosphate+Thumb
2'-Deoxyribonucleoside triphosphate + Thioredoxin disulfide + Water ↔ Ribonucleoside triphosphate + Thioredoxin
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SMPDB Reactions:
Thumb+a reduced flavodoxin → Thumb+an oxidized flavodoxin+Thumb
Guanosine triphosphate + a reduced flavodoxin → dGTP + an oxidized flavodoxin + Water
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Thumb+a reduced flavodoxin → an oxidized flavodoxin+Thumb+dATP+Thumb
Adenosine triphosphate + a reduced flavodoxin → an oxidized flavodoxin + Water + dATP + dATP
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Thumb+a reduced flavodoxin → Thumb+an oxidized flavodoxin+Thumb
Cytidine triphosphate + a reduced flavodoxin → Water + an oxidized flavodoxin + dCTP
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Uridine triphosphate+a reduced flavodoxin+Thumb → Thumb+an oxidized flavodoxin+Thumb
Uridine triphosphate + a reduced flavodoxin + Uridine triphosphate → Water + an oxidized flavodoxin + Deoxyuridine triphosphate
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Thumb+reduced thioredoxin → oxidized thioredoxin +Thumb+dGDP+Thumb
Guanosine diphosphate + reduced thioredoxin → oxidized thioredoxin + Water + dGDP + dGDP
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Adenosine diphosphate+reduced thioredoxin+Thumb ↔ Thumb+oxidized thioredoxin +dADP+Thumb
Adenosine diphosphate + reduced thioredoxin + ADP ↔ Water + oxidized thioredoxin + dADP + dADP
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Uridine 5'-diphosphate+reduced thioredoxin+Thumb ? oxidized thioredoxin +Thumb+dUDP+Thumb
Uridine 5'-diphosphate + reduced thioredoxin + Uridine 5'-diphosphate ? oxidized thioredoxin + Water + dUDP + dUDP
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PseudoCyc/BioCyc Reactions:
Thumb+Thioredoxin disulfide+Thumb ↔ Thumb+Thioredoxin
dATP + Thioredoxin disulfide + Water ↔ Adenosine triphosphate + Thioredoxin
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Thumb+Thioredoxin disulfide+Thumb ↔ Thumb+Thioredoxin
dGTP + Thioredoxin disulfide + Water ↔ Guanosine triphosphate + Thioredoxin
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Thumb+Thioredoxin disulfide+Thumb ↔ Thumb+Thioredoxin
dCTP + Thioredoxin disulfide + Water ↔ Cytidine triphosphate + Thioredoxin
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Thumb+Thioredoxin disulfide+Thumb ↔ Thumb+Thioredoxin
Deoxyuridine triphosphate + Thioredoxin disulfide + Water ↔ Uridine triphosphate + Thioredoxin
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2'-deoxyribonucleoside triphosphate+thioredoxin disulfide+Thumb → ribonucleoside triphosphate+thioredoxin
2'-deoxyribonucleoside triphosphate + thioredoxin disulfide + Water → ribonucleoside triphosphate + thioredoxin
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2'-Deoxyribonucleoside triphosphate+Thioredoxin disulfide+Thumb ↔ Ribonucleoside triphosphate+Thumb
2'-Deoxyribonucleoside triphosphate + Thioredoxin disulfide + Water ↔ Ribonucleoside triphosphate + Thioredoxin
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Thumb+a reduced flavodoxin → Thumb+an oxidized flavodoxin+Thumb
Guanosine triphosphate + a reduced flavodoxin → dGTP + an oxidized flavodoxin + Water
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Thumb+a reduced flavodoxin → an oxidized flavodoxin+Thumb+dATP+Thumb
Adenosine triphosphate + a reduced flavodoxin → an oxidized flavodoxin + Water + dATP + dATP
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Thumb+a reduced flavodoxin → Thumb+an oxidized flavodoxin+Thumb
Cytidine triphosphate + a reduced flavodoxin → Water + an oxidized flavodoxin + dCTP
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Uridine triphosphate+a reduced flavodoxin+Thumb → Thumb+an oxidized flavodoxin+Thumb
Uridine triphosphate + a reduced flavodoxin + Uridine triphosphate → Water + an oxidized flavodoxin + Deoxyuridine triphosphate
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Thumb+reduced thioredoxin → oxidized thioredoxin +Thumb+dGDP+Thumb
Guanosine diphosphate + reduced thioredoxin → oxidized thioredoxin + Water + dGDP + dGDP
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Adenosine diphosphate+reduced thioredoxin+Thumb ↔ Thumb+oxidized thioredoxin +dADP+Thumb
Adenosine diphosphate + reduced thioredoxin + ADP ↔ Water + oxidized thioredoxin + dADP + dADP
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Uridine 5'-diphosphate+reduced thioredoxin+Thumb ? oxidized thioredoxin +Thumb+dUDP+Thumb
Uridine 5'-diphosphate + reduced thioredoxin + Uridine 5'-diphosphate ? oxidized thioredoxin + Water + dUDP + dUDP
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PAMDB000412+PAMDB000142 → PAMDB110477
dATP + Water → ATP
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PAMDB110481+PAMDB000142 → PAMDB110470
dGTP + Water → GTP
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Deoxy-Ribonucleoside-Triphosphates+PAMDB000142 → Ribonucleoside-Triphosphates
Deoxy-Ribonucleoside-Triphosphates + Water → Ribonucleoside-Triphosphates
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Complex Reactions:
Thumb+2 Flavodoxin reduced+2 Thumb → Thumb+2 flavodoxin semi oxidized+Thumb
Cytidine triphosphate + 2 Flavodoxin reduced + 2 Hydrogen ion → dCTP + 2 flavodoxin semi oxidized + Water
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Thumb+2 Flavodoxin reduced+2 Thumb → Thumb+2 flavodoxin semi oxidized+Thumb
Adenosine triphosphate + 2 Flavodoxin reduced + 2 Hydrogen ion → dATP + 2 flavodoxin semi oxidized + Water
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2 Flavodoxin reduced+Thumb+2 Thumb → Thumb+2 flavodoxin semi oxidized+Thumb
2 Flavodoxin reduced + Guanosine triphosphate + 2 Hydrogen ion → dGTP + 2 flavodoxin semi oxidized + Water
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2 Flavodoxin reduced+2 Thumb+Thumb → Thumb+2 flavodoxin semi oxidized+Thumb
2 Flavodoxin reduced + 2 Hydrogen ion + Uridine triphosphate → Deoxyuridine triphosphate + 2 flavodoxin semi oxidized + Water
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2'-deoxyribonucleoside triphosphate+thioredoxin disulfide+Thumb → ribonucleoside triphosphate+thioredoxin
2'-deoxyribonucleoside triphosphate + thioredoxin disulfide + Water → ribonucleoside triphosphate + thioredoxin
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Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB000148Adenosine triphosphateMetaboCard
PAMDB000345ADPMetaboCard
PAMDB000030Cytidine triphosphateMetaboCard
PAMDB001728dADPMetaboCard
PAMDB000412dATPMetaboCard
PAMDB000219dCTPMetaboCard
PAMDB000290Deoxyuridine triphosphateMetaboCard
PAMDB000209dGDPMetaboCard
PAMDB000389dGTPMetaboCard
PAMDB000221dUDPMetaboCard
PAMDB000296Guanosine diphosphateMetaboCard
PAMDB000319Guanosine triphosphateMetaboCard
PAMDB001633Hydrogen ionMetaboCard
PAMDB004174ThioredoxinMetaboCard
PAMDB000123Uridine 5'-diphosphateMetaboCard
PAMDB000117Uridine triphosphateMetaboCard
PAMDB000142WaterMetaboCard
GO Classification:
Function
catalytic activity
oxidoreductase activity
oxidoreductase activity, acting on CH or CH2 groups
oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor
ribonucleoside-triphosphate reductase activity
Process
metabolic process
oxidation reduction
Gene Properties
Locus tag: PA1920
Strand: -
Entrez Gene ID: 882172
Accession: NP_250610.1
GI: 15597116
Sequence start: 2094329
Sequence End: 2096356
Sequence Length: 2027
Gene Sequence: 
>PA1920
ATGACCCAGCCCCGGAAGGCTACCTGGCCGGCCACCCTGCTCAAGCGCAACGGACGTGAAGTCCCTTTCGATCCCGGCAAGATCGAACGCGCCATCGCCGCCGCCGGCCAAGCCACCGGCGAGTTCGACCCGCAGCAGGCGCAGGCGCTCGCCGAACGCGTGGTGGAACGCCTGCCGGAACGCGCCTGCCTGGATATCGAACGGGTCCAGGACCTGGTCGAACGGGTGCTGATGGAGGCCGGCCACTACCCTACGGCGCGCGCCTACGTGGTCTACCGCGAACGCCACGGCCGGCTGCGCCGCGAGCGCAAGACCCTGGTGGACGTCGCCGCGTCGATGAACGAATACCTGTCCCGCGAGGATTGGCGGGTGCGCGCCAACGCCAACCAGGGCTATTCCCTCGGCGGGCTGATCCTCAACGTATCCGGCAAGGTCACCGCGAACTACTGGCTGGATGAGGTCTACGATGCCGACATCGCCGCCGCCCACCGCGACGCCGACCTGCATATCCACGACCTCGACATGCTCGCCGGCTATTGCGCCGGCTGGTCGCTGCGCACCTTGCTGAACGAAGGCCTGAACGGCGTGCCGGGGCGGGTCGAGGCCGGTCCGCCGAAGCACCTGGGCAGCGCCCTGGGGCAGATGGTCAACTTCCTCGGCACCCTGCAGAACGAGTGGGCCGGGGCCCAGGCCTTCAGTTCCTTCGATACCTACCTGGCGCCCTACGTGCGCAAGGACCGCCTCGACTACGCCAGCGTGCGCCAGGCCCTCCAGGAGTTCATCTACAACCTCAACGTGCCGTCGCGCTGGGGCACCCAGACACCCTTCACCAACCTGACCTTCGACTGGGTCTGCCCGGACGACCTGCGCGACCAGGTGCCGCGCATCGGCGGCGAGGAGATGCCCTTCGCCTACGGCGAGCTGCAGGCCGAGATGGACCTGATCAACCGCGCCTACATCGAGGTGATGCAGGCCGGCGATGCCCACGGCCGGGTATTCACCTTCCCGATCCCGACCTACAACATCACCCACGACTTCCCCTGGGACAGCGACAACGCCACGCGCCTGTTCGAGATGACCGCGCGCTACGGCCTGCCCTACTTCCAGAACTTCCTCAACTCGGACATGCAGCCCAACCAGGTGCGCTCGATGTGCTGCCGCCTGCAACTGGACGTGCGCGAACTGCTCAAGCGTGGCAACGGCCTGTTCGGCTCGGCGGAGCAGACCGGCTCGCTGGGCGTGGTGACGATCAACTGCGCGCGCCTGGGCTATCGCCACCGTGGCGACGCCGCCGGCCTCTACCGCCAGCTCGACCACCTGCTCGAACTCGCCTTCGCCAGCCTGGAGCTGAAGCGCAAGGTGATCCAGCAGCACATGGATGCCGGCCTCTATCCCTACACCCGACGCTACCTGGGTACCCTGCGCAACCATTTCTCCACCATCGGCGTGAACGGCCTGCACGAGATGGTGCGCAACTTCAGCGACGACCGCGAGGGACTGCACAGCGAAGCCGGGCGCGAGATGGCCCTGGCCCTGCTCGATCACGTGCGCGCGCGGCTGGTGGGTTTCCAGGAGGACAGCGGGCACCTCTACAACCTGGAAGCCACGCCCGCCGAGGGCACCACCTATCGCTTCGCCCGCGAGGACCGCAAGCGCTATCCGCGCATCCTCCAGGCCGGCACGCCGGAGGCGCCCTACTACACCAACTCCTCGCAACTGCCGGTGGGCTTCACCGACGACCCGTTCGAGGCGCTGGAGCTGCAGGACGCCCTGCAATGCAAGTACACCGGCGGCACCGTGCTGCATCTCTACATGGCCGAGCGGATTTCCTCCGCCGAAGCCTGCAAGACCCTGGTGCGCACCGCCCTCGGTCGCTTCCGCCTGCCGTACCTGACCGTCACCCCCACCTTCTCGATCTGCCCGCGGCACGGCTACCTGGCCGGCGAGCACGAGTTCTGCCCGAAGTGCGACGAGGAGCTGCTGCAACGCTCCACGCCCAAGAGCTGTTGCGGCGGCTGCGGCGGTTGA
Protein Properties
Protein Residues: 675
Protein Molecular Weight: 76.1 kDa
Protein Theoretical pI: 6.55
Hydropathicity (GRAVY score): -0.41
Charge at pH 7 (predicted): -4.83
Protein Sequence: 
>PA1920
MTQPRKATWPATLLKRNGREVPFDPGKIERAIAAAGQATGEFDPQQAQALAERVVERLPERACLDIERVQDLVERVLMEAGHYPTARAYVVYRERHGRLRRERKTLVDVAASMNEYLSREDWRVRANANQGYSLGGLILNVSGKVTANYWLDEVYDADIAAAHRDADLHIHDLDMLAGYCAGWSLRTLLNEGLNGVPGRVEAGPPKHLGSALGQMVNFLGTLQNEWAGAQAFSSFDTYLAPYVRKDRLDYASVRQALQEFIYNLNVPSRWGTQTPFTNLTFDWVCPDDLRDQVPRIGGEEMPFAYGELQAEMDLINRAYIEVMQAGDAHGRVFTFPIPTYNITHDFPWDSDNATRLFEMTARYGLPYFQNFLNSDMQPNQVRSMCCRLQLDVRELLKRGNGLFGSAEQTGSLGVVTINCARLGYRHRGDAAGLYRQLDHLLELAFASLELKRKVIQQHMDAGLYPYTRRYLGTLRNHFSTIGVNGLHEMVRNFSDDREGLHSEAGREMALALLDHVRARLVGFQEDSGHLYNLEATPAEGTTYRFAREDRKRYPRILQAGTPEAPYYTNSSQLPVGFTDDPFEALELQDALQCKYTGGTVLHLYMAERISSAEACKTLVRTALGRFRLPYLTVTPTFSICPRHGYLAGEHEFCPKCDEELLQRSTPKSCCGGCGG
References
External Links:
Resource Link
Genome ID: PA1920
Entrez Gene ID: 882172
NCBI Protein ID: 15597116
General Reference: PaperBLAST - Find papers about PA1920 and its homologs