Nucleoside diphosphate kinase (PA3807)

Identification
Name: Nucleoside diphosphate kinase
Synonyms:
  • NDK
  • NDP kinase
  • Nucleoside-2-P kinase
Gene Name: ndk
Enzyme Class:
Biological Properties
General Function: Involved in nucleoside diphosphate kinase activity
Specific Function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate
Cellular Location: Cytoplasm
KEGG Pathways:
Transports:
Transport References:Not Available
KEGG Reactions: Not Available
SMPDB Reactions: Not Available
PseudoCyc/BioCyc Reactions:
Thumb+Thumb ↔ Thumb+Thumb
Adenosine triphosphate + Uridine 5'-diphosphate ↔ ADP + Uridine triphosphate
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Thumb+Thumb ↔ Thumb+Thumb
Adenosine triphosphate + dGDP ↔ ADP + dGTP
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Thumb+Thumb ↔ Thumb+Thumb
Adenosine triphosphate + Guanosine diphosphate ↔ ADP + Guanosine triphosphate
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Thumb+Thumb ↔ Thumb+Thumb
Adenosine triphosphate + dCDP ↔ ADP + dCTP
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Thumb+Thumb ↔ Thumb+Thumb
Adenosine triphosphate + dTDP ↔ ADP + Thymidine 5'-triphosphate
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Thumb+Thumb ↔ Thumb+Thumb
Adenosine triphosphate + dADP ↔ ADP + dATP
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Thumb+Thumb ↔ Thumb+Thumb
Adenosine triphosphate + dUDP ↔ ADP + Deoxyuridine triphosphate
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Thumb+Thumb ↔ Thumb+Thumb
Adenosine triphosphate + CDP ↔ ADP + Cytidine triphosphate
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Thumb+Thumb ↔ Thumb+Thumb
Adenosine triphosphate + IDP ↔ ADP + Inosine triphosphate
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Thumb+Thumb ↔ Thumb+Thumb
Adenosine triphosphate + DIDP ↔ ADP + 2'-Deoxyinosine triphosphate
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Thumb+Thumb ↔ Thumb+Thumb
Adenosine triphosphate + Uridine 5'-diphosphate ↔ ADP + Uridine triphosphate
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Thumb+Thumb ↔ Thumb+Thumb
Adenosine triphosphate + Guanosine diphosphate ↔ ADP + Guanosine triphosphate
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Thumb+Thumb ↔ Thumb+Thumb
Adenosine triphosphate + CDP ↔ ADP + Cytidine triphosphate
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Thumb+Thumb ↔ Thumb+Thumb
Adenosine triphosphate + dADP ↔ ADP + dATP
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Thumb+dGDP ↔ Thumb+Thumb
Adenosine triphosphate + dGDP ↔ ADP + dGTP
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Thumb+Thumb ↔ Thumb+Thumb
Adenosine triphosphate + dTDP ↔ ADP + Thymidine 5'-triphosphate
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Thumb+Thumb ↔ Thumb+Thumb
Adenosine triphosphate + dCDP ↔ ADP + dCTP
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Thumb+dUDP ↔ Thumb+Thumb
Adenosine triphosphate + dUDP ↔ ADP + Deoxyuridine triphosphate
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Thumb+nucleoside diphosphate → Thumb+nucleoside triphosphate
Adenosine triphosphate + nucleoside diphosphate → ADP + nucleoside triphosphate
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Thumb+NDP ↔ Thumb+Nucleoside triphosphate
Adenosine triphosphate + NDP ↔ ADP + Nucleoside triphosphate
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Thumb+Thumb → Adenosine diphosphate+Thumb+Thumb
Guanosine diphosphate + Adenosine triphosphate → Adenosine diphosphate + Guanosine triphosphate + ADP
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dGDP+Thumb+Thumb → Adenosine diphosphate+Thumb+Thumb
dGDP + Adenosine triphosphate + dGDP → Adenosine diphosphate + dGTP + ADP
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dADP+Thumb+Thumb → Adenosine diphosphate+dATP+Thumb+Thumb
dADP + Adenosine triphosphate + dADP → Adenosine diphosphate + dATP + ADP + dATP
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Uridine 5'-diphosphate+Thumb+Thumb → Uridine triphosphate+Adenosine diphosphate+Thumb+Thumb
Uridine 5'-diphosphate + Adenosine triphosphate + Uridine 5'-diphosphate → Uridine triphosphate + Adenosine diphosphate + Uridine triphosphate + ADP
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Thumb+Thumb → Adenosine diphosphate+Thumb+Thumb
dCDP + Adenosine triphosphate → Adenosine diphosphate + dCTP + ADP
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dUDP+Thumb+Thumb → Adenosine diphosphate+Thumb+Thumb
dUDP + Adenosine triphosphate + dUDP → Adenosine diphosphate + Deoxyuridine triphosphate + ADP
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Thumb+Thumb → Adenosine diphosphate+Thumb+Thumb
Adenosine triphosphate + dTDP → Adenosine diphosphate + Thymidine 5'-triphosphate + ADP
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Thumb
GDP + ATP → GTP + ADP
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PAMDB110477+PAMDB120055 → PAMDB110479+PAMDB120043
ATP + dIDP → ADP + dITP
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PAMDB120252+PAMDB110477 → PAMDB000412+PAMDB110479
dADP + ATP → dATP + ADP
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PAMDB120287+PAMDB110477 → PAMDB110481+PAMDB110479
dGDP + ATP → dGTP + ADP
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Nucleoside-Diphosphates+PAMDB110477 → Nucleoside-Triphosphates+PAMDB110479
Nucleoside-Diphosphates + ATP → Nucleoside-Triphosphates + ADP
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PAMDB110473+PAMDB110479 → PAMDB110470+PAMDB110478
GDP + ADP → GTP + AMP
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PAMDB110477+PAMDB120586 → PAMDB120578+PAMDB110479
ATP + IDP → ITP + ADP
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Complex Reactions: Not Available
Transports:
Metabolites:
PAMDB IDNameView
PAMDB0005932'-Deoxyinosine triphosphateMetaboCard
PAMDB000148Adenosine triphosphateMetaboCard
PAMDB000345ADPMetaboCard
PAMDB000415CDPMetaboCard
PAMDB000030Cytidine triphosphateMetaboCard
PAMDB001728dADPMetaboCard
PAMDB000412dATPMetaboCard
PAMDB000307dCDPMetaboCard
PAMDB000219dCTPMetaboCard
PAMDB000290Deoxyuridine triphosphateMetaboCard
PAMDB000209dGDPMetaboCard
PAMDB000389dGTPMetaboCard
PAMDB000509DIDPMetaboCard
PAMDB000320dTDPMetaboCard
PAMDB000221dUDPMetaboCard
PAMDB000296Guanosine diphosphateMetaboCard
PAMDB000319Guanosine triphosphateMetaboCard
PAMDB000490IDPMetaboCard
PAMDB000078Inosine triphosphateMetaboCard
PAMDB000346Thymidine 5'-triphosphateMetaboCard
PAMDB000123Uridine 5'-diphosphateMetaboCard
PAMDB000117Uridine triphosphateMetaboCard
GO Classification:
Function
adenyl nucleotide binding
adenyl ribonucleotide binding
ATP binding
binding
catalytic activity
nucleoside binding
nucleoside diphosphate kinase activity
phosphotransferase activity, phosphate group as acceptor
purine nucleoside binding
transferase activity
transferase activity, transferring phosphorus-containing groups
Process
cellular nitrogen compound metabolic process
CTP biosynthetic process
GTP biosynthetic process
metabolic process
nitrogen compound metabolic process
nucleobase, nucleoside and nucleotide metabolic process
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
nucleoside phosphate metabolic process
nucleotide metabolic process
purine nucleoside triphosphate biosynthetic process
purine nucleotide biosynthetic process
purine nucleotide metabolic process
purine ribonucleoside triphosphate biosynthetic process
pyrimidine nucleoside triphosphate biosynthetic process
pyrimidine nucleotide biosynthetic process
pyrimidine nucleotide metabolic process
pyrimidine ribonucleoside triphosphate biosynthetic process
UTP biosynthetic process
Gene Properties
Locus tag: PA3807
Strand: -
Entrez Gene ID: 879892
Accession: NP_252496.1
GI: 15599002
Sequence start: 4266470
Sequence End: 4266901
Sequence Length: 431
Gene Sequence: 
>PA3807
ATGGCACTGCAACGCACCCTGTCCATCATCAAGCCGGACGCCGTTTCCAAGAACGTGATCGGCGAAATCCTGACCCGCTTCGAGAAAGCCGGCCTGCGCGTCGTCGCCGCTAAAATGGTTCAGCTGTCCGAGCGTGAAGCCGGTGGCTTCTATGCCGAGCACAAAGAGCGTCCGTTCTTCAAGGACCTGGTTTCCTTCATGACTTCCGGTCCGGTTGTAGTCCAGGTTCTGGAAGGCGAGGACGCCATCGCCAAGAACCGCGAGCTGATGGGCGCCACCGATCCGAAGAAAGCCGACGCCGGTACCATCCGCGCCGACTTCGCCGTCTCCATCGACGAGAACGCCGTCCACGGTTCCGATTCCGAAGCTTCCGCCGCTCGCGAGATCGCCTACTTCTTCGCGGCTACCGAAGTCTGCGAGCGCATTCGCTGA
Protein Properties
Protein Residues: 143
Protein Molecular Weight: 15.6 kDa
Protein Theoretical pI: 5.31
Hydropathicity (GRAVY score): -0.089
Charge at pH 7 (predicted): -2.55
Protein Sequence: 
>PA3807
MALQRTLSIIKPDAVSKNVIGEILTRFEKAGLRVVAAKMVQLSEREAGGFYAEHKERPFFKDLVSFMTSGPVVVQVLEGEDAIAKNRELMGATDPKKADAGTIRADFAVSIDENAVHGSDSEASAAREIAYFFAATEVCERIR
References
External Links:
Resource Link
Genome ID: PA3807
Entrez Gene ID: 879892
NCBI Protein ID: 15599002
General Reference: PaperBLAST - Find papers about PA3807 and its homologs