Anaerobic ribonucleoside-triphosphate reductase-activating protein (PA1919)

Identification
Name: Anaerobic ribonucleoside-triphosphate reductase-activating protein
Synonyms:
  • Class III anaerobic ribonucleotide reductase small component
Gene Name: nrdG
Enzyme Class:
Biological Properties
General Function: Involved in [formate-C-acetyltransferase]-activating enzyme activity
Specific Function: Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
Cellular Location: Cytoplasm
KEGG Pathways:
    KEGG Reactions: Not Available
    SMPDB Reactions: Not Available
    PseudoCyc/BioCyc Reactions:
    Complex Reactions:
    Thumb+2 Flavodoxin reduced+2 Thumb → Thumb+2 flavodoxin semi oxidized+Thumb
    Cytidine triphosphate + 2 Flavodoxin reduced + 2 Hydrogen ion → dCTP + 2 flavodoxin semi oxidized + Water
    ReactionCard
    Thumb+2 Flavodoxin reduced+2 Thumb → Thumb+2 flavodoxin semi oxidized+Thumb
    Adenosine triphosphate + 2 Flavodoxin reduced + 2 Hydrogen ion → dATP + 2 flavodoxin semi oxidized + Water
    ReactionCard
    2 Flavodoxin reduced+Thumb+2 Thumb → Thumb+2 flavodoxin semi oxidized+Thumb
    2 Flavodoxin reduced + Guanosine triphosphate + 2 Hydrogen ion → dGTP + 2 flavodoxin semi oxidized + Water
    ReactionCard
    2 Flavodoxin reduced+2 Thumb+Thumb → Thumb+2 flavodoxin semi oxidized+Thumb
    2 Flavodoxin reduced + 2 Hydrogen ion + Uridine triphosphate → Deoxyuridine triphosphate + 2 flavodoxin semi oxidized + Water
    ReactionCard
    Transports: Not Available
    Metabolites:
    PAMDB IDNameView
    PAMDB0015835'-DeoxyadenosineMetaboCard
    PAMDB000148Adenosine triphosphateMetaboCard
    PAMDB000030Cytidine triphosphateMetaboCard
    PAMDB000412dATPMetaboCard
    PAMDB000219dCTPMetaboCard
    PAMDB000290Deoxyuridine triphosphateMetaboCard
    PAMDB000389dGTPMetaboCard
    PAMDB000319Guanosine triphosphateMetaboCard
    PAMDB001633Hydrogen ionMetaboCard
    PAMDB000175L-MethionineMetaboCard
    PAMDB000289S-AdenosylmethionineMetaboCard
    PAMDB000117Uridine triphosphateMetaboCard
    PAMDB000142WaterMetaboCard
    GO Classification:
    Component
    cell part
    cytoplasm
    intracellular part
    Function
    4 iron, 4 sulfur cluster binding
    binding
    catalytic activity
    iron-sulfur cluster binding
    metal cluster binding
    oxidoreductase activity
    [formate-C-acetyltransferase]-activating enzyme activity
    Process
    cellular metabolic process
    metabolic process
    oxidation reduction
    oxygen and reactive oxygen species metabolic process
    Gene Properties
    Locus tag: PA1919
    Strand: -
    Entrez Gene ID: 880910
    Accession: NP_250609.1
    GI: 15597115
    Sequence start: 2093444
    Sequence End: 2094142
    Sequence Length: 698
    Gene Sequence: 
    >PA1919
ATGAGCGCCACGCTCAGGGTCGGGGGCCTGGTGCCCCTGACCACCCTCGACTACCCCGGCCTGCTCGCCTGCGTGCTGTTCTGCCAGGGCTGCGCCTGGCGCTGCCGCTACTGCCACAACCCGGAACTGATCGCGCCGCGCGGCGCGGAGGAAATCCCCTGGCCACGCCTGCTCGACTTCCTCCGCCGACGCCAAGGCCTGTTGCAGGCGGTGGTCTTCAGCGGCGGCGAGGCGACCCTGCAGGCGGCCCTCGGCGACGCCATGCGCACGGTCCGCGAACTGGGCTTCCGCGTCGGCCTGCACAGCGCCGGCATCAACCCCCGCGCCTTCGCCCGGGTGCTGGCGCAGAGCGACTGGGTGGGCTTCGACGTCAAGGCGCCGGCCGAGGACGTCGCCGCCATTACCGGCGTGGACGGCAGCGGCGCGGCCAACTGGCGCAGCCTGGAATGCCTGCTGGTCAGCGGCGTGGCCTACGAATGCCGGACCACGGTGCACTGGCGCTTGTTCGATAGCGAACGCCTCTGGCGCCTGGCGACGCGCCTGCGCGAGATGGGCGTGGAGCGCTTCGCCGTACAACTGGCGCGCCCGGCCCGCCAGCTCGATCCGCAGCTTCTCGCGAAGCCCGCGCCGCAGGGCGCTGCGCAGCTATGGCGAGAACTGGAAGAGCTGTTTCCCGCCTTCGAACTGCGCGACGCCTGA
    Protein Properties
    Protein Residues: 232
    Protein Molecular Weight: 25.7 kDa
    Protein Theoretical pI: 8.05
    Hydropathicity (GRAVY score): 0.033
    Charge at pH 7 (predicted): 2.51
    Protein Sequence: 
    >PA1919
MSATLRVGGLVPLTTLDYPGLLACVLFCQGCAWRCRYCHNPELIAPRGAEEIPWPRLLDFLRRRQGLLQAVVFSGGEATLQAALGDAMRTVRELGFRVGLHSAGINPRAFARVLAQSDWVGFDVKAPAEDVAAITGVDGSGAANWRSLECLLVSGVAYECRTTVHWRLFDSERLWRLATRLREMGVERFAVQLARPARQLDPQLLAKPAPQGAAQLWRELEELFPAFELRDA
    References
    External Links:
    Resource Link
    Genome ID: PA1919
    Entrez Gene ID: 880910
    NCBI Protein ID: 15597115
    General Reference: PaperBLAST - Find papers about PA1919 and its homologs