DNA-directed RNA polymerase subunit beta (PA4270)

Identification
Name: DNA-directed RNA polymerase subunit beta
Synonyms:
  • RNAP subunit beta
  • RNA polymerase subunit beta
  • Transcriptase subunit beta
Gene Name: rpoB
Enzyme Class:
Biological Properties
General Function: Involved in DNA binding
Specific Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Cellular Location: Cytoplasmic
KEGG Pathways:
KEGG Reactions:
Thumb+RNA+RNA ↔ Thumb+RNA
Adenosine triphosphate + RNA + RNA ↔ Pyrophosphate + RNA
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Thumb+RNA ↔ Thumb+RNA
Guanosine triphosphate + RNA ↔ Pyrophosphate + RNA
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Thumb+RNA ↔ Thumb+RNA
Cytidine triphosphate + RNA ↔ Pyrophosphate + RNA
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Thumb+RNA ↔ Thumb+RNA
Uridine triphosphate + RNA ↔ Pyrophosphate + RNA
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Nucleoside triphosphate+RNA ↔ Thumb
Nucleoside triphosphate + RNA ↔ Pyrophosphate
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SMPDB Reactions: Not Available
PseudoCyc/BioCyc Reactions:
Thumb+RNA+RNA ↔ Thumb+RNA
Adenosine triphosphate + RNA + RNA ↔ Pyrophosphate + RNA
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Thumb+RNA ↔ Thumb+RNA
Guanosine triphosphate + RNA ↔ Pyrophosphate + RNA
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Thumb+RNA ↔ Thumb+RNA
Cytidine triphosphate + RNA ↔ Pyrophosphate + RNA
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Thumb+RNA ↔ Thumb+RNA
Uridine triphosphate + RNA ↔ Pyrophosphate + RNA
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Nucleoside triphosphate+RNA(n) → Thumb+RNA(n+1)
Nucleoside triphosphate + RNA(n) → Pyrophosphate + RNA(n+1)
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Nucleoside triphosphate+RNA ↔ Thumb
Nucleoside triphosphate + RNA ↔ Pyrophosphate
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Thumb
a nucleoside triphosphate + RNA(n) = RNA(n+1) + diphosphate
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Complex Reactions:
Nucleoside triphosphate+RNA(n) → Thumb+RNA(n+1)
Nucleoside triphosphate + RNA(n) → Pyrophosphate + RNA(n+1)
ReactionCard
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB000148Adenosine triphosphateMetaboCard
PAMDB000030Cytidine triphosphateMetaboCard
PAMDB000319Guanosine triphosphateMetaboCard
PAMDB000633PyrophosphateMetaboCard
PAMDB000117Uridine triphosphateMetaboCard
GO Classification:
Function
binding
catalytic activity
DNA binding
DNA-directed RNA polymerase activity
nucleic acid binding
nucleoside binding
nucleotidyltransferase activity
ribonucleoside binding
RNA polymerase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
Process
biosynthetic process
cellular macromolecule biosynthetic process
macromolecule biosynthetic process
metabolic process
transcription
transcription, DNA-dependent
Gene Properties
Locus tag: PA4270
Strand: -
Entrez Gene ID: 881699
Accession: NP_252960.1
GI: 15599466
Sequence start: 4776544
Sequence End: 4780617
Sequence Length: 4073
Gene Sequence: 
>PA4270
ATGGCTTACTCATACACTGAGAAAAAACGTATCCGCAAGGACTTTAGCAAGTTGCCGGACGTCATGGATGTGCCGTATTTGCTGGCCATCCAGCTGGATTCCTATCGCGAATTCCTGCAGGCTGGCGCAACCAAGGAGCAGTTCCGCGATGTCGGTCTGCACGCGGCCTTCAAGTCCGTTTTCCCGATTATCAGCTATTCCGGCAATGCTGCCCTGGAATACGTCGGCTACCGTCTGGGTGAGCCGGCATTCGATGTCAAGGAGTGCGTGCTGCGCGGCGTGACCTTCGCCGTACCGCTGCGCGTGAAAGTTCGCCTGATCATCTTCGACCGCGAGTCGTCGAACAAGGCGATCAAGGACATCAAGGAACAAGAAGTCTACATGGGGGAAATCCCCCTGATGACCGAGAACGGTACCTTCATCATCAACGGTACCGAGCGTGTCATCGTCTCCCAGCTGCACCGTTCCCCGGGCGTGTTCTTCGACCACGACCGTGGCAAGACCCACAGCTCCGGCAAGCTGCTGTACTCCGCGCGGATCATTCCTTACCGCGGTTCCTGGCTGGACTTCGAGTTCGATCCGAAGGACTGCGTGTTCGTCCGTATCGACCGTCGCCGCAAGCTGCCGGCCTCGGTACTGCTGCGCGCGCTCGGCTACAGCACGGAAGAGATCCTCAACGCCTTCTACGCGACCAACGTCTTCCACATCAAGGGCGAGACCCTGAACCTGGAACTGGTCCCGCAGCGCCTGCGCGGTGAAGTCGCGAGCATCGACATCAAGGATGGCAGCGGCAAGGTGATCGTGGAGCAGGGGCGTCGTATCACTGCCCGCCACATCAACCAGCTGGAAAAGGCTGGCGTGAGCCAGCTGGAAGTGCCGTTCGACTACCTGATCGGCCGTACCATCGCCAAGGCGATCGTGCATCCGGCTACCGGCGAGATCATCGCCGAGTGCAACACCGAGCTGACCCTCGACCTCCTGGCCAAGGTGGCCAAGGCCCAGGTCGTGCGCATCGAGACCCTGTACACCAACGACATCGACTGCGGTCCGTTCATCTCCGACACCCTGAAGATCGACAACACCAGCAACCAGCTGGAAGCCCTGGTCGAGATCTACCGGATGATGCGTCCGGGCGAGCCGCCGACCAAGGAAGCTGCCGAGACCCTGTTCGGCAACCTGTTCTTCAGCGCCGAGCGTTACGACCTGTCGGCCGTAGGCCGGATGAAGTTCAACCGCCGTATCGGTCGTACCGAGATCGAAGGTCCGGGCGTCCTGAGCAAGGAAGACATCATCGATGTGCTCAAGACCCTCGTCGACATCCGTAACGGCAAGGGCATCGTCGATGACATCGACCACCTGGGCAACCGTCGTGTCCGTTGCGTCGGCGAAATGGCCGAGAACCAGTTCCGCGTGGGCCTGGTGCGTGTCGAGCGCGCGGTCAAGGAACGCCTGTCCATGGCCGAAAGCGAAGGCCTGATGCCGCAAGACCTGATCAACGCCAAGCCGGTGGCTGCCGCGATCAAGGAGTTCTTCGGTTCGAGCCAGCTGTCGCAGTTCATGGACCAGAACAACCCGCTTTCCGAGATCACCCACAAGCGCCGCGTCTCCGCGCTCGGCCCGGGCGGTCTGACCCGTGAGCGTGCGGGCTTCGAGGTTCGTGACGTACACCCGACCCACTACGGCCGCGTGTGCCCGATCGAAACCCCTGAAGGTCCGAACATCGGTCTGATCAACTCCCTGGCGACCTACGCCCGCACCAACAAGTACGGCTTCCTCGAGAGCCCGTACCGCGTGGTCAAGGACAGCCTGGTAACCGACGAGATCGTGTTCCTGTCGGCGATCGAAGAAGCCGACCACGTCATCGCCCAGGCTTCGGCGACCCTCAACGAGAAGGGTCAACTGGTGGACGAGCTGGTGGCCGTGCGTCACCTGAACGAATTCACCGTGAAGGCGCCGGAAGACGTGACCCTGATGGACGTGTCGCCGAAGCAGGTCGTTTCCGTCGCTGCCTCGCTGATTCCGTTCCTCGAGCACGATGACGCCAACCGCGCACTCATGGGCTCGAACATGCAGCGTCAGGCCGTGCCGACCCTGCGTGCCGACAAGCCGCTGGTGGGTACCGGCATGGAGCGCAACGTGGCGCGCGACTCCGGCGTCTGCGTCGTGGCTCGCCGTGGCGGTGTGATCGACTCGGTCGATGCCAGCCGTGTCGTGGTTCGCGTGGCGGATGACGAAGTCGAGACCGGCGAAGCGGGTGTCGACATCTACAACCTGACCAAGTACACTCGTTCCAACCAGAACACCTGCATCAACCAGCGTCCGCTGGTGAGCAAGGGTGACGTGGTCGCGCGCGGCGACATCCTGGCCGACGGTCCGTCCACCGACATGGGCGAACTGGCCCTGGGCCAGAACATGCGCGTAGCGTTCATGCCCTGGAACGGCTTCAACTTCGAAGACTCCATCTGCCTGTCCGAGCGCGTGGTCCAGGAAGATCGTTTCACCACGATCCACATCCAGGAACTGACCTGCGTCGCTCGTGACACCAAGCTCGGCCCAGAGGAAATCACCGCGGACATCCCGAACGTGGGCGAGGCCGCGCTGAACAAGCTGGACGAAGCCGGTATCGTCTACGTCGGCGCCGAAGTGCAGGCCGGCGACATCCTGGTCGGCAAGGTCACTCCGAAAGGCGAGACCCAGCTGACTCCGGAAGAGAAGCTGCTGCGCGCGATCTTCGGTGAGAAGGCGTCCGACGTGAAGGACACCTCCCTGCGTGTGCCGACCGGCACCAAGGGTACCGTCATCGACGTTCAGGTCTTCACCCGCGACGGCGTCGAGCGCGATTCCCGCGCGCTGTCCATCGAGAAGATGCAACTCGACCAGATCCGCAAGGACCTGAACGAAGAGTTCCGCATCGTCGAAGGCGCGACCTTCGAGCGTCTGCGTGCCGCCCTGGTCGGTGCCAAGGCTGAAGGTGGCCCGGCGCTGAAGAAGGGCACGGAGATCACCGACGACTACCTCGACGGTCTCGAGCGCGGCCAGTGGTTCAAGCTGCGCATGGCCGACGACGCCCTGAACGAACAGCTGGAGAAGGCCCAGGCCTACATCAGCGATCGTCGCCAGCTCCTGGACGACAAGTTCGAGGACAAGAAGCGCAAGCTGCAGCAGGGCGACGACCTGGCTCCGGGCGTGCTGAAGATCGTCAAGGTCTACCTGGCGATCAAGCGTCGCATCCAGCCGGGCGACAAGATGGCCGGCCGTCACGGTAACAAGGGTGTGGTCTCGGTGATCATGCCGGTGGAAGACATGCCGCACGATGCCAACGGCACCCCGGTCGACATCGTCCTCAACCCGCTGGGCGTACCGTCGCGTATGAACGTCGGTCAGATCCTCGAAACCCACCTGGGCCTCGCGGCCAAGGGGCTGGGCGAGAAGATCAACCGCATGCTCGAAGAGCAGCGCAAGGTCGCCGAACTGCGTAAGTTCCTGCACGAGATCTACAACGAGATCGGCGGTCGCGAGGAAAACCTCGACGAGCTGGGCGACAACGAGATCCTCGCGCTGGCCAAGAACCTGCGCGGTGGCGTACCGATGGCGACCCCGGTGTTCGATGGCGCCAAGGAACGCGAGATCAAGGCCATGCTGAAGCTGGCCGACCTGCCGGAAAGCGGCCAGATGCGTCTGTTCGACGGCCGTACCGGCAACCAGTTCGAGCGTCCGACCACCGTCGGCTACATGTACATGCTCAAGCTGAACCACCTGGTGGACGACAAGATGCACGCCCGTTCCACCGGCTCGTACAGCCTGGTTACCCAGCAGCCGCTGGGTGGTAAGGCACAGTTCGGTGGTCAGCGCTTCGGTGAGATGGAGGTGTGGGCGCTGGAAGCCTATGGCGCGGCGTACACCCTGCAGGAAATGCTGACGGTCAAGTCGGACGACGTGAACGGCCGGACCAAGATGTACAAGAACATCGTGGACGGCGATCACCGCATGGAGGCCGGCATGCCCGAGTCCTTCAACGTTCTGATCAAAGAGATCCGTTCGCTCGGCATCGACATCGAACTGGAAACCGAATAA
Protein Properties
Protein Residues: 1357
Protein Molecular Weight: 150.8 kDa
Protein Theoretical pI: 5.58
Hydropathicity (GRAVY score): -0.286
Charge at pH 7 (predicted): -19.87
Protein Sequence: 
>PA4270
MAYSYTEKKRIRKDFSKLPDVMDVPYLLAIQLDSYREFLQAGATKEQFRDVGLHAAFKSVFPIISYSGNAALEYVGYRLGEPAFDVKECVLRGVTFAVPLRVKVRLIIFDRESSNKAIKDIKEQEVYMGEIPLMTENGTFIINGTERVIVSQLHRSPGVFFDHDRGKTHSSGKLLYSARIIPYRGSWLDFEFDPKDCVFVRIDRRRKLPASVLLRALGYSTEEILNAFYATNVFHIKGETLNLELVPQRLRGEVASIDIKDGSGKVIVEQGRRITARHINQLEKAGVSQLEVPFDYLIGRTIAKAIVHPATGEIIAECNTELTLDLLAKVAKAQVVRIETLYTNDIDCGPFISDTLKIDNTSNQLEALVEIYRMMRPGEPPTKEAAETLFGNLFFSAERYDLSAVGRMKFNRRIGRTEIEGPGVLSKEDIIDVLKTLVDIRNGKGIVDDIDHLGNRRVRCVGEMAENQFRVGLVRVERAVKERLSMAESEGLMPQDLINAKPVAAAIKEFFGSSQLSQFMDQNNPLSEITHKRRVSALGPGGLTRERAGFEVRDVHPTHYGRVCPIETPEGPNIGLINSLATYARTNKYGFLESPYRVVKDSLVTDEIVFLSAIEEADHVIAQASATLNEKGQLVDELVAVRHLNEFTVKAPEDVTLMDVSPKQVVSVAASLIPFLEHDDANRALMGSNMQRQAVPTLRADKPLVGTGMERNVARDSGVCVVARRGGVIDSVDASRVVVRVADDEVETGEAGVDIYNLTKYTRSNQNTCINQRPLVSKGDVVARGDILADGPSTDMGELALGQNMRVAFMPWNGFNFEDSICLSERVVQEDRFTTIHIQELTCVARDTKLGPEEITADIPNVGEAALNKLDEAGIVYVGAEVQAGDILVGKVTPKGETQLTPEEKLLRAIFGEKASDVKDTSLRVPTGTKGTVIDVQVFTRDGVERDSRALSIEKMQLDQIRKDLNEEFRIVEGATFERLRAALVGAKAEGGPALKKGTEITDDYLDGLERGQWFKLRMADDALNEQLEKAQAYISDRRQLLDDKFEDKKRKLQQGDDLAPGVLKIVKVYLAIKRRIQPGDKMAGRHGNKGVVSVIMPVEDMPHDANGTPVDIVLNPLGVPSRMNVGQILETHLGLAAKGLGEKINRMLEEQRKVAELRKFLHEIYNEIGGREENLDELGDNEILALAKNLRGGVPMATPVFDGAKEREIKAMLKLADLPESGQMRLFDGRTGNQFERPTTVGYMYMLKLNHLVDDKMHARSTGSYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQEMLTVKSDDVNGRTKMYKNIVDGDHRMEAGMPESFNVLIKEIRSLGIDIELETE
References
External Links:
Resource Link
Genome ID: PA4270
Entrez Gene ID: 881699
NCBI Protein ID: 15599466
General Reference: PaperBLAST - Find papers about PA4270 and its homologs