Identification
Name: Pyruvate dehydrogenase [cytochrome]
Synonyms:
  • Pyruvate dehydrogenase [Ubiquinone]
  • Pyruvate oxidase
  • POX
  • Alpha-peptide
Gene Name: poxB
Enzyme Class:
Biological Properties
General Function: Involved in magnesium ion binding
Specific Function: Pyruvate + ferricytochrome b1 + H(2)O = acetate + CO(2) + ferrocytochrome b1
Cellular Location: Cell membrane; Peripheral membrane protein
KEGG Pathways:
KEGG Reactions:
Thumb+Thumb+ThumbThumb+Thumb+Thumb
SMPDB Reactions:
2 Thumb+2 ThumbThumb+Thumb+Thumb+Electron
PseudoCyc/BioCyc Reactions:
PAMDB110761+PAMDB000142+UbiquinonesPAMDB000568+Ubiquinols+PAMDB110762
pyruvate + Water + Ubiquinones → Carbon dioxide + Ubiquinols + acetate
ReactionCard
Thumb+Thumb+ThumbThumb+Thumb+Thumb
Thumb+Thumb+ThumbThumb+Thumb+Thumb
Thumb+Thumb+ThumbThumb+Thumb+Thumb
Thumb
pyruvate + a ferricytochrome b1 + H2O → acetate + CO2 + a ferrocytochrome b1
ReactionCard
PAMDB110762+PAMDB000568+PAMDB001633PAMDB110761+PAMDB000142
Complex Reactions:
Thumb+Thumb+ThumbThumb+Thumb+Thumb
Thumb+Thumb+ThumbThumb+Thumb+Thumb
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB000012Acetic acidMetaboCard
PAMDB000484AcetoinMetaboCard
PAMDB000568Carbon dioxideMetaboCard
PAMDB001633Hydrogen ionMetaboCard
PAMDB000102Pyruvic acidMetaboCard
PAMDB001968Ubiquinol-1MetaboCard
PAMDB000237Ubiquinol-8MetaboCard
PAMDB001302Ubiquinone-0MetaboCard
PAMDB001833Ubiquinone-1MetaboCard
PAMDB000242Ubiquinone-10MetaboCard
PAMDB001700Ubiquinone-8MetaboCard
PAMDB000142WaterMetaboCard
GO Classification:
Function
binding
catalytic activity
cation binding
ion binding
magnesium ion binding
metal ion binding
thiamin pyrophosphate binding
transferase activity
vitamin binding
Gene Properties
Locus tag: PA5297
Strand: +
Entrez Gene ID: 881392
Accession: NP_253984.1
GI: 15600490
Sequence start: 5964859
Sequence End: 5966577
Sequence Length: 1718
Gene Sequence:
>PA5297
ATGTCGAGCAAGAAAGTCGCCGAGATCGTCGTGGAAACCCTGGAAGCCGCCGGCGTCCGCCATTGCTATGGCATCGTCGGCGACACCCTCAACCATGTCACCGACGCCATCCATCGCAGCCAGATCCAGTGGGTCCACGTGCGCCACGAAGAAGCGGCGGCCTTCGCCGCGGGCGCCGAGTCCTACATCAGCGGACGCCTGACCGCCTGCGCCGGCTCCTGCGGACCGGGCAGCCTGCACTTCATCAACGGCGTCTACGAGGCCCAGCGCAACCGCGCGCCGATGGTCCTGATCGCCAGCCAGATCGTCACCCCGCAACTGGGCATGGAGTTTCCCCAGGAGGTCGACTTCAAGGCGGTCTACGCCAGCTGCTCGGTGTTCTGCGAGCAGGTGCACAGCCCGGAACAGGCGCGCCGGGTGGTGGCCCTGGCCTGCCAGGCGGCGCTCAACCGGCGCGGCGTGGCGGTGGTGATCCTGCCGGCCGACATCAGCCAGGCCACGGTGAAGGACGACCTGCCGTTCTCGGTGCATTTCCCGCAACCGGTGCTGCGCCCCAGCGACGCCGAACTGCAGGACGTCGCCCGCCTGCTGGCCCACGGCAAGAAGATCGGCATCTACGCCGGCTCCGGCTGCCAGGGCGCCCACGACCTGCTGGTGGCCCTCGCCGACCGCCTCAAGGCGCCCATCGCGCACACGTCGCGGGCCAAGGACTTCGTCGAGTACGACAACCCCTTCAACATGGGCATGACCGGTATGCTCGGGATCGAGTCCGGCTTCCACATGATGACCGAGTGCGACACCCTCCTGCTGCTCGGCGCCGACTTCGCCTGGGCGCAGTTCTATCCGCAGAAGGCCACCCTGATCCAGGTCGACCGCGATGGCAGTCACCTGGGCCGCCGCCACCCCATCGATCTCGGCGTGGTCGGCGACGTGATCCCCACCCTCGAGGCGCTCTTGCCGTTGCTCGAAGCCCGCGAGGAGCGCAGCTTCCTCGACGAATGCCTGGAGCACCGCGAGCGCTCGCTGCGGACGCTGGAAAAAGAGGAGCAAGCCGGCAAGGGCGAGCTGATCCATCCGCAGCACCTGGTCAGCCTGCTCGACCAGCACGCCAGCGAGGACGCCCTGTTCACCGCCGACGGCGGCTCGGCGATGGTCTGGCTGTTGCGTCACATCCACAGCAACGGCAAGCGCCGCACCCTCACCAGCCTGGTCCACGGCACCATGGCCAACGCCATGCCCCAGGCGCTGGGACTGAAGAAGGCCTACCCCGAGCGCCAGGTAATCTCGATCTCCGGCGACGGCGGCCTGGCCATGCTGCTCGGCGACCTGCTGACGGCCATCCAGGAAAAACTGCCGATCAAGGTAGTGGTGCTGAACAATGCCTCGCTGAACTTCGTCGAGCTGGAACAGAAGGTCGAGGGCCTGCTGGACAACTACACCGACCTGCTCAACCCGGACTTCGCCCGTCTCGCCGAAGTGATCGGCTTCCACGGACGCAAGGTGACGCGCTCCGAGGAGCTCGAGGCGGCGGTGCAGGAGTTCCTCGCCCAGCCCGGTCCGGCGCTGCTGGACGTGCATACCAACCCTGCGGAGCTGGTGATGCCGCCGAAGATCGAGTTCGGCCAGGTCGCCGACACCGCGCTCTACGCCGCCAAGGCCGTGCTCAGCGGGCGCTTCAAGGACGTCGAGACGCTACTGGTGAACAACCTGCTGAAATGA
Protein Properties
Protein Residues: 572
Protein Molecular Weight: 62.3 kDa
Protein Theoretical pI: 6.02
Hydropathicity (GRAVY score): 0.006
Charge at pH 7 (predicted): -12.71
Protein Sequence:
>PA5297
MSSKKVAEIVVETLEAAGVRHCYGIVGDTLNHVTDAIHRSQIQWVHVRHEEAAAFAAGAESYISGRLTACAGSCGPGSLHFINGVYEAQRNRAPMVLIASQIVTPQLGMEFPQEVDFKAVYASCSVFCEQVHSPEQARRVVALACQAALNRRGVAVVILPADISQATVKDDLPFSVHFPQPVLRPSDAELQDVARLLAHGKKIGIYAGSGCQGAHDLLVALADRLKAPIAHTSRAKDFVEYDNPFNMGMTGMLGIESGFHMMTECDTLLLLGADFAWAQFYPQKATLIQVDRDGSHLGRRHPIDLGVVGDVIPTLEALLPLLEAREERSFLDECLEHRERSLRTLEKEEQAGKGELIHPQHLVSLLDQHASEDALFTADGGSAMVWLLRHIHSNGKRRTLTSLVHGTMANAMPQALGLKKAYPERQVISISGDGGLAMLLGDLLTAIQEKLPIKVVVLNNASLNFVELEQKVEGLLDNYTDLLNPDFARLAEVIGFHGRKVTRSEELEAAVQEFLAQPGPALLDVHTNPAELVMPPKIEFGQVADTALYAAKAVLSGRFKDVETLLVNNLLK
References
External Links:
Resource Link
Genome ID: PA5297
Entrez Gene ID: 881392
NCBI Protein ID: 15600490
General Reference: PaperBLAST - Find papers about PA5297 and its homologs