Identification
Name: NADH-quinone oxidoreductase subunit F
Synonyms:
  • NADH dehydrogenase I subunit F
  • NDH-1 subunit F
  • NUO6
Gene Name: nuoF
Enzyme Class:
Biological Properties
General Function: Involved in NADH dehydrogenase (ubiquinone) activity
Specific Function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Cellular Location: Not Available
KEGG Pathways:
KEGG Reactions:
Thumb+AcceptorThumb+Reduced acceptor
Ubiquinol-8 + Acceptor ↔ Ubiquinone-1 + Reduced acceptor
ReactionCard
Thumb+ThumbThumb+Thumb
SMPDB Reactions:
Thumb+5 Thumb+ThumbThumb+Thumb+Thumb
Thumb+4 Thumb+2 Thumb+menaquinone-8 ? Thumb+Thumb+Thumb+Electron+4 Thumb
"a menaquinone"+4 Thumb+Thumb"a menaquinol"+Thumb
"a menaquinone" + 4 Hydrogen ion + NADH → "a menaquinol" + NAD
ReactionCard
4 Thumb+Thumb+"a menaquinone"Thumb+"a menaquinol"
4 Hydrogen ion + NADH + "a menaquinone" → NAD + "a menaquinol"
ReactionCard
PseudoCyc/BioCyc Reactions:
Thumb+AcceptorThumb+Reduced acceptor
Ubiquinol-8 + Acceptor ↔ Ubiquinone-1 + Reduced acceptor
ReactionCard
Thumb+ThumbThumb+Thumb
Thumb+ThumbThumb+Thumb
Thumb+ThumbThumb+Thumb
Thumb+ThumbThumb+Thumb
Thumb+ThumbThumb+Thumb
Thumb+ThumbThumb+Thumb
Thumb+ThumbThumb+Thumb
Thumb+ThumbThumb+Thumb
Thumb+ThumbThumb+Thumb
Thumb+ThumbThumb+Thumb
Thumb+5 Thumb+ThumbThumb+Thumb+Thumb
Thumb+4 Thumb+2 Thumb+menaquinone-8 ? Thumb+Thumb+Thumb+Electron+4 Thumb
Thumb
NADH + an oxidized unknown electron acceptor + H+ = NAD+ + an reduced unknown electron acceptor
ReactionCard
PAMDB110540+PAMDB001633+ETR-QuinonesPAMDB110542+ETR-Quinols
NADH + Hydrogen ion + ETR-Quinones → NAD+ + ETR-Quinols
ReactionCard
PAMDB000610+PAMDB110540+PAMDB001633PAMDB120506+PAMDB110542
Complex Reactions:
Thumb+4 Thumb+ThumbThumb+Thumb+3 Thumb
4 Thumb+Thumb+ThumbThumb+Thumb+3 Thumb
4 Thumb+Menaquinone 8+ThumbThumb+Thumb+3 Thumb
Thumb+ThumbThumb+Thumb
Thumb+ThumbThumb+Thumb
Thumb+ThumbThumb+Thumb
Thumb+ThumbThumb+Thumb
Thumb+ThumbThumb+Thumb
Thumb+ThumbThumb+Thumb
Thumb+ThumbThumb+Thumb
Thumb+ThumbThumb+Thumb
Thumb+ThumbThumb+Thumb
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB0015632-Demethylmenaquinol 8MetaboCard
PAMDB0015642-Demethylmenaquinone 8MetaboCard
PAMDB001633Hydrogen ionMetaboCard
PAMDB000459HydroquinoneMetaboCard
PAMDB001653Menaquinol 8MetaboCard
PAMDB000197NADMetaboCard
PAMDB000398NADHMetaboCard
PAMDB003450QuinoneMetaboCard
PAMDB001968Ubiquinol-1MetaboCard
PAMDB000237Ubiquinol-8MetaboCard
PAMDB001833Ubiquinone-1MetaboCard
PAMDB001700Ubiquinone-8MetaboCard
GO Classification:
Function
4 iron, 4 sulfur cluster binding
binding
catalytic activity
FMN binding
iron-sulfur cluster binding
metal cluster binding
NAD or NADH binding
NADH dehydrogenase (quinone) activity
NADH dehydrogenase (ubiquinone) activity
NADH dehydrogenase activity
nucleotide binding
oxidoreductase activity
oxidoreductase activity, acting on NADH or NADPH
Process
metabolic process
oxidation reduction
Gene Properties
Locus tag: PA2641
Strand: +
Entrez Gene ID: 882348
Accession: NP_251331.1
GI: 15597837
Sequence start: 2986243
Sequence End: 2987589
Sequence Length: 1346
Gene Sequence:
>PA2641
ATGACCCTTACCTCCATTGGTCCGGCCAACCGCATGGCGCGTTCGGCGGAAACCCATCCGCTGACCTGGCGCCTGCGCGAAGACGCCCAGCCCGTCTGGCTCGAGGAATATCAGAGCAAGGACGGCTATGCCGCGGCGCGCAAGGCGCTGACCCAGATGGCCCAGGACGACATCGTCCAGACCGTCAAGGACTCCGGCCTCAAGGGCCGCGGCGGCGCGGGCTTCCCCACCGGAGTGAAGTGGGGCCTGATGCCGAAGGACGAGTCGCTGAACATCCGCTACCTGCTGTGCAACGCGGACGAGATGGAGCCGAACACCTGGAAGGACCGCATGCTCATGGAGCAGCTGCCGCACCTGCTGGTGGAAGGCATGCTGATTTCCGCGCGCGCGCTGAAGGCCTACCGCGGCTACATCTTCCTGCGCGGCGAATACGTCGACGCGGCGCGCAACCTCAACCGCGCCATCGACGAAGCCAAGGCCGCCGGCCTGCTCGGCAAGAACATCCTCGGCAGCGGCTTCGATTTCGAGCTGTTCGTCCACACCGGTGCCGGCCGCTACATCTGCGGCGAAGAGACCGCGCTGATCAACTCGCTGGAAGGCCGCCGCGCCAACCCGCGTTCCAAACCGCCCTTCCCTGCCGCCGTCGGCGTCTGGGGCAAGCCGACCTGCGTGAACAACGTGGAGACGCTGTGCAACGTGCCGGCCATCGTCGGCAACGGCGTGGACTGGTACAAGACCCTGGCCCGCCCCGGCAGCGAAGACATGGGCACCAAGCTGATGGGCTTCTCCGGCAAGGTGAAGAACCCCGGCCTGTGGGAACTGCCGTTCGGCGTCAGCGCCCGCGAGCTGTTCGAGGACTACGCCGGCGGCATGCGCGACGGCTTCCAGCTCAAGGCCTGGCAGCCCGGCGGCGCCGGTACCGGCTTCCTGCTCCCGGAGCACCTGGATGCGCAGATGTTCGCCGGCGGCATCGCCAAGGTCGGCACCCGGATGGGCACCGGCCTGGCCATGGCGGTGGACGACAGCATCAACATGGTTTCCCTGCTGCGCAACATGGAAGAGTTCTTCGCCCGCGAGTCCTGCGGCTGGTGCACCCCCTGCCGCGATGGCCTGCCGTGGAGCGTGAAGCTGCTGCGTGCCCTGGAGCGGGGCGAAGGCCAGCCCGGCGACCTCGAGACCCTCGAGCAGCTGGTCAACTTCCTCGGCCCAGGCAAGACCTTCTGCGCCCACGCGCCGGGAGCCGTCGAGCCGCTGGGCAGCGCCCTCAAGTATTTCCGTGCCGAATTCGAGGCGGGCATCTCCCGCCAGCCTTCGGCCGCGCCGCGCCCGGCAACGGTCGGCGCCTGA
Protein Properties
Protein Residues: 448
Protein Molecular Weight: 48.7 kDa
Protein Theoretical pI: 6.99
Hydropathicity (GRAVY score): -0.232
Charge at pH 7 (predicted): -0.02
Protein Sequence:
>PA2641
MTLTSIGPANRMARSAETHPLTWRLREDAQPVWLEEYQSKDGYAAARKALTQMAQDDIVQTVKDSGLKGRGGAGFPTGVKWGLMPKDESLNIRYLLCNADEMEPNTWKDRMLMEQLPHLLVEGMLISARALKAYRGYIFLRGEYVDAARNLNRAIDEAKAAGLLGKNILGSGFDFELFVHTGAGRYICGEETALINSLEGRRANPRSKPPFPAAVGVWGKPTCVNNVETLCNVPAIVGNGVDWYKTLARPGSEDMGTKLMGFSGKVKNPGLWELPFGVSARELFEDYAGGMRDGFQLKAWQPGGAGTGFLLPEHLDAQMFAGGIAKVGTRMGTGLAMAVDDSINMVSLLRNMEEFFARESCGWCTPCRDGLPWSVKLLRALERGEGQPGDLETLEQLVNFLGPGKTFCAHAPGAVEPLGSALKYFRAEFEAGISRQPSAAPRPATVGA
References
External Links:
Resource Link
Genome ID: PA2641
Entrez Gene ID: 882348
NCBI Protein ID: 15597837
General Reference: PaperBLAST - Find papers about PA2641 and its homologs