Identification
Name: GSH-dependent disulfide bond oxidoreductase
Synonyms: Not Available
Gene Name: yfcG
Enzyme Class:
Biological Properties
General Function: Not Available
Specific Function: protein binding
Cellular Location: Not Available
KEGG Pathways:
KEGG Reactions:
RX+ThumbHalide+R-S-Glutathione
RX + Glutathione ↔ Halide + R-S-Glutathione
ReactionCard
Thumb+ThumbThumb
Thumb+ThumbThumb
Thumb+ThumbThumb
Thumb+ThumbThumb
Thumb+ThumbThumb
Thumb+ThumbThumb
Thumb+ThumbThumb
Thumb+ThumbThumb+Thumb
Thumb+ThumbThumb
Thumb+ThumbThumb+Hydrochloric acid
Thumb+ThumbThumb+Hydrochloric acid
Trichloroethene+ThumbThumb+Hydrochloric acid
Trichloroethene + GlutathioneS-(1,2-Dichlorovinyl)glutathione + Hydrochloric acid
ReactionCard
1,2-Dibromoethane+Thumb+ThumbThumb+2 Hydrobromic acid
1,2-Dibromoethane + Glutathione + Hydrogen ionGlutathione episulfonium ion + 2 Hydrobromic acid
ReactionCard
Aflatoxin B1-exo-8,9-epoxide+ThumbAflatoxin B1exo-8,9-epoxide-GSH
Aflatoxin B1-exo-8,9-epoxide + Glutathione ↔ Aflatoxin B1exo-8,9-epoxide-GSH
ReactionCard
RX+ThumbThumb+R-S-Glutathione
RX + GlutathioneHalide + R-S-Glutathione
ReactionCard
SMPDB Reactions:
Thumb+ThumbThumb+Hydrochloric acid
PseudoCyc/BioCyc Reactions:
RX+ThumbHalide+R-S-Glutathione
RX + Glutathione ↔ Halide + R-S-Glutathione
ReactionCard
Thumb+ThumbThumb
Thumb+ThumbThumb
Thumb+ThumbThumb
Thumb+ThumbThumb
Thumb+ThumbThumb
Thumb+ThumbThumb
Thumb+ThumbThumb
Thumb+ThumbThumb+Thumb
Thumb+ThumbThumb
Thumb+ThumbThumb+Hydrochloric acid
Thumb+ThumbThumb+Hydrochloric acid
Trichloroethene+ThumbThumb+Hydrochloric acid
Trichloroethene + GlutathioneS-(1,2-Dichlorovinyl)glutathione + Hydrochloric acid
ReactionCard
1,2-Dibromoethane+Thumb+ThumbThumb+2 Hydrobromic acid
1,2-Dibromoethane + Glutathione + Hydrogen ionGlutathione episulfonium ion + 2 Hydrobromic acid
ReactionCard
Aflatoxin B1-exo-8,9-epoxide+ThumbAflatoxin B1exo-8,9-epoxide-GSH
Aflatoxin B1-exo-8,9-epoxide + Glutathione ↔ Aflatoxin B1exo-8,9-epoxide-GSH
ReactionCard
RX+ThumbThumb+R-S-Glutathione
RX + GlutathioneHalide + R-S-Glutathione
ReactionCard
Thumb
glutathione + RX = a glutathione-toxin conjugate + HX
ReactionCard
PAMDB110431+PAMDB120148PAMDB120134
PAMDB120194+PAMDB110431PAMDB001633+PAMDB120184+PAMDB000573
Complex Reactions: Not Available
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB000852(1R)-Glutathionyl-(2R)-hydroxy-1,2-dihydronaphthaleneMetaboCard
PAMDB000853(1R)-Hydroxy-(2R)-glutathionyl-1,2-dihydronaphthaleneMetaboCard
PAMDB000850(1R,2S)-Naphthalene 1,2-oxideMetaboCard
PAMDB000855(1S)-Hydroxy-(2S)-glutathionyl-1,2-dihydronaphthaleneMetaboCard
PAMDB0008731-Nitro-5-glutathionyl-6-hydroxy-5,6-dihydronaphthaleneMetaboCard
PAMDB0008741-Nitro-5-hydroxy-6-glutathionyl-5,6-dihydronaphthaleneMetaboCard
PAMDB0008751-Nitro-7-glutathionyl-8-hydroxy-7,8-dihydronaphthaleneMetaboCard
PAMDB0008761-Nitro-7-hydroxy-8-glutathionyl-7,8-dihydronaphthaleneMetaboCard
PAMDB0008771-Nitronaphthalene-5,6-oxideMetaboCard
PAMDB0008781-Nitronaphthalene-7,8-oxideMetaboCard
PAMDB0009022,2-DichloroacetaldehydeMetaboCard
PAMDB0009042,3-Dihydro-2-S-glutathionyl-3-hydroxy bromobenzeneMetaboCard
PAMDB0008832-(S-Glutathionyl)acetyl chlorideMetaboCard
PAMDB0008842-(S-Glutathionyl)acetyl glutathioneMetaboCard
PAMDB0009273,4-Dihydro-3-hydroxy-4-S-glutathionyl bromobenzeneMetaboCard
PAMDB0009444,5-Dihydro-4-hydroxy-5-S-glutathionyl-benzo[a]pyreneMetaboCard
PAMDB0009364-Glutathionyl cyclophosphamideMetaboCard
PAMDB0009587,8-Dihydro-7-hydroxy-8-S-glutathionyl-benzo[a]pyreneMetaboCard
PAMDB000966Benzo[a]pyrene-4,5-oxideMetaboCard
PAMDB000967Benzo[a]pyrene-7,8-diolMetaboCard
PAMDB000973Bromobenzene-2,3-oxideMetaboCard
PAMDB000974Bromobenzene-3,4-oxideMetaboCard
PAMDB000048GlutathioneMetaboCard
PAMDB001001Glutathione episulfonium ionMetaboCard
PAMDB004133HalideMetaboCard
PAMDB001633Hydrogen ionMetaboCard
PAMDB001032S-(1,2-Dichlorovinyl)glutathioneMetaboCard
PAMDB001034S-(2,2-Dichloro-1-hydroxy)ethyl glutathioneMetaboCard
PAMDB001033S-(2-Chloroacetyl)glutathioneMetaboCard
PAMDB001035S-(Formylmethyl)glutathioneMetaboCard
PAMDB000142WaterMetaboCard
GO Classification:
Function
protein binding
Gene Properties
Locus tag: PA1033
Strand: -
Entrez Gene ID: 880186
Accession: NP_249724.1
GI: 15596230
Sequence start: 1122340
Sequence End: 1122981
Sequence Length: 641
Gene Sequence:
>PA1033
ATGATCGACCTGTACTACTGGACCACCCCGAACGGCCACAAGATTACTCTTTTCCTGGAAGAAACCGGCCTGCCCTACGCCATCCATCCGATCAACATCAGCCAGGGCGACCAGTTCCAGGCGGATTTCCTGAAGGTGTCGCCGAACAACAAGATTCCCGCCATCGTCGATCGCCAACCGGCCGACGGCGGCGCTCCCCTGTCGCTGTTCGAGTCCGGCGCCATCCTGCTCTATCTCGCGGAAAAGACTGGACGCTTCCTCGCCAAGGACCTGCGCGCGCGCCAGGAAACCCTGCAGTGGCTGTTCTGGCAGATGGGCGGGCTGGGGCCGATGGCCGGGCAGAACCACCATTTCAACCGCTTCGCCCCGGAGAAGATTCCCTACGCCATCGACCGGTACGTCAAGGAAACCGCGCGCCTGTACGGCGTTCTCGACCAGCGCCTGGCGGACCGCGCCTTCGTCGCCGGCGACGACTACAGCATCGCCGACATGGCCATCTATCCGTGGATCGTCCCGCACCAGTGGCAGGAGCAGGATCTCGCCGACTTCCCGCACCTGCAGCGCTGGTTCGAGAGCATTCGCCAGCGTCCGGCGACGCAACGCGCCTATGCTTTGGTGGAGCGCATCAATCCGCCGAAGTAG
Protein Properties
Protein Residues: 213
Protein Molecular Weight: 24.5 kDa
Protein Theoretical pI: 6.81
Hydropathicity (GRAVY score): -0.372
Charge at pH 7 (predicted): -0.57
Protein Sequence:
>PA1033
MIDLYYWTTPNGHKITLFLEETGLPYAIHPINISQGDQFQADFLKVSPNNKIPAIVDRQPADGGAPLSLFESGAILLYLAEKTGRFLAKDLRARQETLQWLFWQMGGLGPMAGQNHHFNRFAPEKIPYAIDRYVKETARLYGVLDQRLADRAFVAGDDYSIADMAIYPWIVPHQWQEQDLADFPHLQRWFESIRQRPATQRAYALVERINPPK
References
External Links:
Resource Link
Genome ID: PA1033
Entrez Gene ID: 880186
NCBI Protein ID: 15596230
General Reference: PaperBLAST - Find papers about PA1033 and its homologs