Riboflavin synthase alpha chain (PA4053)

Identification
Name: Riboflavin synthase alpha chain
Synonyms: Not Available
Gene Name: ribE
Enzyme Class:
Biological Properties
General Function: Involved in riboflavin synthase activity
Specific Function: Riboflavin synthase is a bifunctional enzyme complex catalyzing the formation of riboflavin from 5-amino-6-(1'-D)- ribityl-amino-2,4(1H,3H)-pyrimidinedione and L-3,4-dihydrohy-2- butanone-4-phosphate via 6,7-dimethyl-8-lumazine. The alpha subunit catalyzes the dismutation of 6,7-dimethyl-8-lumazine to riboflavin and 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)- pyrimidinedione
Cellular Location: Not Available
KEGG Pathways:
KEGG Reactions:
2 Thumb → Thumb+Thumb
2 6,7-Dimethyl-8-(1-D-ribityl)lumazine → 5-Amino-6-ribitylamino uracil + Riboflavin
ReactionCard
Thumb+Thumb → Thumb+2 Thumb+Thumb
5-Amino-6-ribitylamino uracil + 3,4-Dihydroxy-2-butanone-4-P → 6,7-Dimethyl-8-(1-D-ribityl)lumazine + 2 Water + Phosphate
ReactionCard
2 Thumb ↔ Thumb+Thumb
2 6,7-Dimethyl-8-(1-D-ribityl)lumazine ↔ Riboflavin + 5-Amino-6-ribitylamino uracil
ReactionCard
SMPDB Reactions:
Thumb+Thumb → Thumb+Thumb+Thumb+6,7-Dimethyl-8-(1-D-ribityl)lumazine+Thumb
5-Amino-6-ribitylamino uracil + 1-Deoxy-L-glycero-tetrulose 4-phosphate → Water + Phosphate + Hydrogen ion + 6,7-Dimethyl-8-(1-D-ribityl)lumazine + 6,7-Dimethyl-8-(1-D-ribityl)lumazine
ReactionCard
6,7-Dimethyl-8-(1-D-ribityl)lumazine+Thumb+Thumb → Riboflavin+Thumb+Thumb
6,7-Dimethyl-8-(1-D-ribityl)lumazine + Hydrogen ion + 6,7-Dimethyl-8-(1-D-ribityl)lumazine → Riboflavin + 5-Amino-6-ribitylamino uracil + Riboflavin
ReactionCard
Thumb+Thumb → Thumb+2 Thumb+Thumb
5-Amino-6-ribitylamino uracil + 3,4-Dihydroxy-2-butanone-4-P → 6,7-Dimethyl-8-(1-D-ribityl)lumazine + 2 Water + Phosphate
ReactionCard
Thumb+Thumb → Thumb+Thumb
Adenosine + Water → beta-D-ribofuranose + Adenine
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PseudoCyc/BioCyc Reactions:
2 Thumb → Thumb+Thumb
2 6,7-Dimethyl-8-(1-D-ribityl)lumazine → 5-Amino-6-ribitylamino uracil + Riboflavin
ReactionCard
Thumb+Thumb → Thumb+2 Thumb+Thumb
5-Amino-6-ribitylamino uracil + 3,4-Dihydroxy-2-butanone-4-P → 6,7-Dimethyl-8-(1-D-ribityl)lumazine + 2 Water + Phosphate
ReactionCard
2 Thumb ↔ Thumb+Thumb
2 6,7-Dimethyl-8-(1-D-ribityl)lumazine ↔ Riboflavin + 5-Amino-6-ribitylamino uracil
ReactionCard
Thumb
1-deoxy-L-glycero-tetrulose 4-phosphate + 5-amino-6-(D-ribitylamino)uracil → 6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + H+ + 2 H2O
ReactionCard
Complex Reactions: Not Available
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB0035121-Deoxy-L-glycero-tetrulose 4-phosphateMetaboCard
PAMDB0005903,4-Dihydroxy-2-butanone-4-PMetaboCard
PAMDB0034065-amino-6-(D-ribitylamino)uracilMetaboCard
PAMDB0006355-Amino-6-ribitylamino uracilMetaboCard
PAMDB0005246,7-Dimethyl-8-(1-D-ribityl)lumazineMetaboCard
PAMDB000010AdenineMetaboCard
PAMDB000016AdenosineMetaboCard
PAMDB001172beta-D-ribofuranoseMetaboCard
PAMDB001633Hydrogen ionMetaboCard
PAMDB000383PhosphateMetaboCard
PAMDB000103RiboflavinMetaboCard
PAMDB000142WaterMetaboCard
GO Classification:
Function
catalytic activity
riboflavin synthase activity
transferase activity
transferase activity, transferring alkyl or aryl (other than methyl) groups
Process
metabolic process
nitrogen compound metabolic process
riboflavin biosynthetic process
riboflavin metabolic process
Gene Properties
Locus tag: PA4053
Strand: -
Entrez Gene ID: 879081
Accession: NP_252742.1
GI: 15599248
Sequence start: 4534116
Sequence End: 4534592
Sequence Length: 476
Gene Sequence: 
>PA4053
ATGACCCTGAAGACCATCGAAGGTACCTTCATTGCCCCCAAAGGCCGCTACGCCCTGGTGGTCGGCCGCTTCAACAGCTTCGTCGTGGAAAGCCTGGTCAGCGGCGCCGTCGACGCCCTGGTCCGCCACGGCGTGGCTGAAAGCGAGATCACCATCATCCGCGCCCCGGGTGCCTTCGAGATCCCGCTGGTGACCCAGAAGGTCGCCCAGCAAGGCGGCTTCGACGCCATCATCGCCCTCGGCGCGGTGATCCGTGGCGGCACCCCGCACTTCGAATACGTGGCTGGCGAGTGCACCAAGGGCCTGGCCCAGGTGTCCCTGCAGTTCGGCATCCCGGTCGCCTTCGGCGTCCTCACCGTCGACTCCATCGAGCAGGCCATCGAGCGCTCCGGCACCAAGGCCGGCAACAAGGGCGCCGAAGCCGCGCTGTCGGCCCTGGAAATGGTCAGCCTGCTGGCGCAGTTGGAGGCCAAGTGA
Protein Properties
Protein Residues: 158
Protein Molecular Weight: 16.4 kDa
Protein Theoretical pI: 5.75
Hydropathicity (GRAVY score): 0.449
Charge at pH 7 (predicted): -1.56
Protein Sequence: 
>PA4053
MTLKTIEGTFIAPKGRYALVVGRFNSFVVESLVSGAVDALVRHGVAESEITIIRAPGAFEIPLVTQKVAQQGGFDAIIALGAVIRGGTPHFEYVAGECTKGLAQVSLQFGIPVAFGVLTVDSIEQAIERSGTKAGNKGAEAALSALEMVSLLAQLEAK
References
External Links:
Resource Link
Genome ID: PA4053
Entrez Gene ID: 879081
NCBI Protein ID: 15599248
General Reference: PaperBLAST - Find papers about PA4053 and its homologs