Reaction Details
Reaction: Thumb
1-deoxy-L-glycero-tetrulose 4-phosphate + 5-amino-6-(D-ribitylamino)uracil → 6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + H+ + 2 H2O
Enzymes:
External Links:
ResourceLink
PseudoCyc Reaction ID:LUMAZINESYN-RXN
References:
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  • Cushman M, Yang D, Gerhardt S, Huber R, Fischer M, Kis K, Bacher A (2002). "Design, synthesis, and evaluation of 6-carboxyalkyl and 6-phosphonoxyalkyl derivatives of 7-oxo-8-ribitylaminolumazines as inhibitors of riboflavin synthase and lumazine synthase." J Org Chem 67(16);5807-16. PMID: 12153285
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  • Haase I, Mortl S, Kohler P, Bacher A, Fischer M (2003). "Biosynthesis of riboflavin in archaea. 6,7-dimethyl-8-ribityllumazine synthase of Methanococcus jannaschii." Eur J Biochem 270(5);1025-32. PMID: 12603336
  • Jordan DB, Bacot KO, Carlson TJ, Kessel M, Viitanen PV (1999). "Plant riboflavin biosynthesis. Cloning, chloroplast localization, expression, purification, and partial characterization of spinach lumazine synthase." J Biol Chem 274(31);22114-21. PMID: 10419541
  • Kis K, Volk R, Bacher A (1995). "Biosynthesis of riboflavin. Studies on the reaction mechanism of 6,7-dimethyl-8-ribityllumazine synthase." Biochemistry 34(9);2883-92. PMID: 7893702
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  • Morgunova E, Saller S, Haase I, Cushman M, Bacher A, Fischer M, Ladenstein R (2007). "Lumazine synthase from Candida albicans as an anti-fungal target enzyme: structural and biochemical basis for drug design." J Biol Chem 282(23);17231-41. PMID: 17446177
  • Mortl S, Fischer M, Richter G, Tack J, Weinkauf S, Bacher A (1996). "Biosynthesis of riboflavin. Lumazine synthase of Escherichia coli." J Biol Chem 1996;271(52);33201-7. PMID: 8969176
  • Zhang X, Meining W, Fischer M, Bacher A, Ladenstein R (2001). "X-ray structure analysis and crystallographic refinement of lumazine synthase from the hyperthermophile Aquifex aeolicus at 1.6 A resolution: determinants of thermostability revealed from structural comparisons." J Mol Biol 306(5);1099-114. PMID: 11237620