Quinoprotein glucose dehydrogenase (PA2290)

Identification
Name: Quinoprotein glucose dehydrogenase
Synonyms:
  • Glucose dehydrogenase [pyrroloquinoline-quinone]
Gene Name: gcd
Enzyme Class:
Biological Properties
General Function: Involved in oxidoreductase activity, acting on CH-OH group of donors
Specific Function: GDH is probably involved in energy conservation rather than in sugar metabolism
Cellular Location: Cell inner membrane; Multi-pass membrane protein; Periplasmic side
KEGG Pathways:
KEGG Reactions:
Thumb+Thumb ↔ Thumb+Thumb
D-Glucose + Ubiquinone-1 ↔ Gluconolactone + Ubiquinol-8
ReactionCard
SMPDB Reactions: Not Available
PseudoCyc/BioCyc Reactions:
Thumb+a ubiquinone → Thumb+a ubiquinol
b-D-Glucose + a ubiquinone → Gluconolactone + a ubiquinol
ReactionCard
Complex Reactions:
Thumb+Thumb+Thumb → Thumb+Thumb+Thumb
Ubiquinone-8 + D-Glucose + Water → Ubiquinol-8 + Gluconic acid + Hydrogen ion
ReactionCard
Thumb+Thumb → Thumb+Thumb
D-Glucose + Ubiquinone-10 → Gluconolactone + Ubiquinol-1
ReactionCard
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB000145b-D-GlucoseMetaboCard
PAMDB000045D-GlucoseMetaboCard
PAMDB000160Gluconic acidMetaboCard
PAMDB000057GluconolactoneMetaboCard
PAMDB001633Hydrogen ionMetaboCard
PAMDB001856Pyrroloquinoline quinoneMetaboCard
PAMDB001968Ubiquinol-1MetaboCard
PAMDB000237Ubiquinol-8MetaboCard
PAMDB001833Ubiquinone-1MetaboCard
PAMDB000242Ubiquinone-10MetaboCard
PAMDB001700Ubiquinone-8MetaboCard
PAMDB000142WaterMetaboCard
GO Classification:
Component
cell part
integral to membrane
intrinsic to membrane
membrane part
outer membrane-bounded periplasmic space
periplasmic space
Function
binding
catalytic activity
cofactor binding
oxidoreductase activity
oxidoreductase activity, acting on CH-OH group of donors
quinone binding
Process
metabolic process
oxidation reduction
Gene Properties
Locus tag: PA2290
Strand: -
Entrez Gene ID: 877639
Accession: NP_250980.1
GI: 15597486
Sequence start: 2518693
Sequence End: 2521104
Sequence Length: 2411
Gene Sequence: 
>PA2290
ATGAGCGAAGGTAACCGCAGTCGATCGCGCCTGCTGCCGAGCCTGCTCGGCCTGTTGATCCTGCTGTCCGGCCTGGCGCTGCTGGCCGGCGGCATCAAGCTGGCGAGCCTGGGCGGCTCGCTGTACTACCTGCTGGCCGGCATCGGCCTGGCCCTGAGCGGACTGTTGCTGCTGCTGGGCAAGCGTGCGGCGCTAGGCCTGTACGCTCTGGTGCTGTTCGCCAGCACCGTCTGGGCGCTGTGGGAAGTCGGCCTGGACTGGTGGCAACTGGTGCCGCGCCTGGCTCTGTGGTTCGTCTTCGGCCTGCTGCTCTGGCTACCCTGGTTCCGCCGCCCGCTGCTGGCCGACGGTCCGGCGCCGCTGGGCACCGCGGCGCTGGGCGTGGCGGTGGTCCTGGCCGGCGCCGCCGCGGTGGGCAGCCAGTTCACCAATCCGGGGCAGATCGTCGGTCGCATCGACCGCGACAGCGGCATGACCAGCACCGCCCCGGCGATGCCGGACGGCGACTGGCAGGCCTACGGGCGCACCGAGTTCGGCGACCGCTACTCGCCGTTGAAGCAGATCACCCCGGCCAACGTCGGCCAGCTCGAGGAAGCCTGGCGCATCCGTACCGGCGACCTGCCGACCGCCGACGATCCGCTCGAACTGACCAACGAGAACACCCCGCTGAAGGTCAACGGCATGCTCTACGCCTGCACCGCGCACAGCAAGGTGCTGGCCCTCGACCCGGACACCGGCGCGGAAATCTGGCGCTTCGATCCGCAGATCCAGAGCCCGGTAGGCTTCAAGGGCTTCGCCCACATGACTTGCCGTGGCGTCTCCTACTACGACGAAGAGCAGTACGCCAGGAGCGACGTCGGCGCGCCGCCGGCCGCGCTCTCCGAGGCCGGCAAGGCGGTCGCCGCCAGTTGTCCGCGGCGCCTGTTCCTGCCCACCGCCGACGCCCGCCTGATCGCGATCAACGCCGACAACGGCAAGGTCTGCGAGGACTTCGGGGTCAAGGGCGCGGTCGACCTGACGGCCGGCATCGGTCCGTTCACCCCGGGCGGCTACTACTCCACCTCGCCGGCGGCGGTCACCCGCAATCTGGTGATCATCGGCGGCCACGTCACCGACAACGAGTCGACCAACGAGCCGTCCGGGGTGATCCGCGCCTTCGACGTGCACGACGGCAAGCTGGTGTGGAACTGGGACAGCGGCAACCCGGACGAGACCGAGCCCCTGGCGCCCGGCAAGTTCTATACCCGCAACTCGCCGAACATGTGGTCGCTGGCCAGCGTCGACGAGAAGCTCGGCCAGGTCTACCTGCCGCTGGGCAACCAGATGCCCGACCAGTGGGGCGGCAACCGCACCCCTGGCGCCGAGAAGTTCAGCGCCGGCCTGGTGGCCCTCGACCTGAACACCGGCAAGCTGCGCTGGAACTACCAGTTCACCCACCACGACCTGTGGGACATGGACGTCGGCAGCCAGCCGACCCTGCTCGACCTGAAGACCGCCGATGGCGTCAAGCCGGCGCTGATCGCGCCGACCAAGCAGGGCAGCCTGTACGTGCTGGACCGCCGCGACGGCACGCCGATCGTGCCGATCCGCGAAGTGCCGGCGCCGCAGGGCGCGGTGGAGGGCGACCATACCGCGCCGACCCAGGCGCGTTCCGACCTCAACCTGCTGCGCCCGCCGCTGACCGAGCGCGACATGTGGGGCAGCAGCCCGTTCGACCAGATGCTCTGCCGCATCCAGTTCCGCTCGCTGCGCTACGAGGGCCAGTACACCCCGCCGTCGGAGCAGGGCAGCCTGATCTATCCGGGCAACGTCGGAGTGTTCAACTGGGGCGGGGTGTCGGTCGACCCGGTGCGCCAGATCCTCTTCACCAGCCCCAACTACATGGCCTTCGTCTCGCAGATGGTGCCGCGCGACAAGGTGCCCAGCGGAAGCAAGCGCGAGGGCGAGACCAGCGGCGTGCAGCCGAACACCGGCGCGCCCTACGCGGTGATCATGCATCCGTTCATGTCGCCCATCGGCCTGCCGTGCCAGGCGCCGTCCTGGGGTGACGTGGCGGGTATCGACCTGACCACCGCCAAGGTCGTCTGGCAGCACAAGAACGGCACCAGCCGCGACAACACCCCGGTGCCGATCGGCCTCACCGTCGGCGTACCGAGCATGGGCGGCTCGATCACCACCGCCGGCGGCGTGGCCTTCCTCAGCGGCACGCTCGACCAGTACCTGCGCGCCTACGACGTGAAGGACGGCAAGCAGCTCTGGCAGGCGCGCCTGCCGGCCGGCGGCCAGGCCACGCCGATGAGCTACACCGGCAAGGACGGTCGCCAGTACGTGCTGATCGTCGCTGGCGGACACGGCTCCTTCGGTACCCGCATGGGCGACTACATCATCGCCTACGCCCTGCCCAGGCAATGA
Protein Properties
Protein Residues: 803
Protein Molecular Weight: 86.2 kDa
Protein Theoretical pI: 6.21
Hydropathicity (GRAVY score): -0.098
Charge at pH 7 (predicted): -4.76
Protein Sequence: 
>PA2290
MSEGNRSRSRLLPSLLGLLILLSGLALLAGGIKLASLGGSLYYLLAGIGLALSGLLLLLGKRAALGLYALVLFASTVWALWEVGLDWWQLVPRLALWFVFGLLLWLPWFRRPLLADGPAPLGTAALGVAVVLAGAAAVGSQFTNPGQIVGRIDRDSGMTSTAPAMPDGDWQAYGRTEFGDRYSPLKQITPANVGQLEEAWRIRTGDLPTADDPLELTNENTPLKVNGMLYACTAHSKVLALDPDTGAEIWRFDPQIQSPVGFKGFAHMTCRGVSYYDEEQYARSDVGAPPAALSEAGKAVAASCPRRLFLPTADARLIAINADNGKVCEDFGVKGAVDLTAGIGPFTPGGYYSTSPAAVTRNLVIIGGHVTDNESTNEPSGVIRAFDVHDGKLVWNWDSGNPDETEPLAPGKFYTRNSPNMWSLASVDEKLGQVYLPLGNQMPDQWGGNRTPGAEKFSAGLVALDLNTGKLRWNYQFTHHDLWDMDVGSQPTLLDLKTADGVKPALIAPTKQGSLYVLDRRDGTPIVPIREVPAPQGAVEGDHTAPTQARSDLNLLRPPLTERDMWGSSPFDQMLCRIQFRSLRYEGQYTPPSEQGSLIYPGNVGVFNWGGVSVDPVRQILFTSPNYMAFVSQMVPRDKVPSGSKREGETSGVQPNTGAPYAVIMHPFMSPIGLPCQAPSWGDVAGIDLTTAKVVWQHKNGTSRDNTPVPIGLTVGVPSMGGSITTAGGVAFLSGTLDQYLRAYDVKDGKQLWQARLPAGGQATPMSYTGKDGRQYVLIVAGGHGSFGTRMGDYIIAYALPRQ
References
External Links:
Resource Link
Genome ID: PA2290
Entrez Gene ID: 877639
NCBI Protein ID: 15597486
General Reference: PaperBLAST - Find papers about PA2290 and its homologs