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S-adenosyl-L-methionine	+		→		+		+		+

S-adenosyl-L-methionine + Coproporphyrinogen III → 5'-Deoxyadenosine + L-Methionine + Carbon dioxide + Protoporphyrinogen IX

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	+	menaquinone-8	→		+

Protoporphyrinogen IX + menaquinone-8 → Protoporphyrin IX + Menaquinol 6

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	+		→	2	+

Protoporphyrin IX + Iron → 2 Hydrogen ion + ferroheme b

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	+		+	Farnesyl pyrophosphate	+		→		+	Pyrophosphate

ferroheme b + Water + Farnesyl pyrophosphate + Farnesyl pyrophosphate → Heme O + Pyrophosphate

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	+		→

ferroheme b + Hydrogen peroxide → Heme D

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	+	S-adenosyl-L-methionine	→		+		+

Uroporphyrinogen III + S-adenosyl-L-methionine → Hydrogen ion + S-Adenosylhomocysteine + Precorrin-1

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	+	S-adenosyl-L-methionine	→	Precorrin-2	+

Precorrin-1 + S-adenosyl-L-methionine → Precorrin-2 + S-Adenosylhomocysteine

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Precorrin-2	+		→		+		+

Precorrin-2 + NAD → NADH + Hydrogen ion + Sirohydrochlorin

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	+		→		+	Propionyl-CoA	+

2-Ketobutyric acid + Coenzyme A → Formic acid + Propionyl-CoA + Propionyl-CoA

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Propionyl-CoA	+		+		→		+	propanoyl phosphate	+

Propionyl-CoA + Phosphate + Propionyl-CoA → Coenzyme A + propanoyl phosphate + Propanoyl phosphate