Histidinol dehydrogenase (PA4448)

Identification
Name: Histidinol dehydrogenase
Synonyms:
  • HDH
Gene Name: hisD
Enzyme Class:
Biological Properties
General Function: Involved in oxidoreductase activity
Specific Function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
Cellular Location: Not Available
KEGG Pathways:
KEGG Reactions:
Thumb+Thumb+Thumb ↔ Thumb+Thumb+Thumb
L-Histidinal + Water + NAD ↔ L-Histidine + NADH + Hydrogen ion
ReactionCard
Thumb+Thumb ↔ Thumb+Thumb+Thumb
L-Histidinol + NAD ↔ L-Histidinal + NADH + Hydrogen ion
ReactionCard
Thumb+2 Thumb+Thumb ↔ Thumb+2 Thumb+3 Thumb
L-Histidinol + 2 NAD + Water ↔ L-Histidine + 2 NADH + 3 Hydrogen ion
ReactionCard
SMPDB Reactions:
Thumb+Thumb → Thumb+Thumb+Histidinal
L-Histidinol + NAD → NADH + Hydrogen ion + Histidinal
ReactionCard
Thumb+Thumb+Histidinal → 2 Thumb+Thumb+L-Histidine+Thumb
Water + NAD + Histidinal → 2 Hydrogen ion + NADH + L-Histidine + L-Histidine
ReactionCard
PseudoCyc/BioCyc Reactions:
Thumb+Thumb+2 Thumb → 3 Thumb+Thumb+2 Thumb
Water + L-Histidinol + 2 NAD → 3 Hydrogen ion + L-Histidine + 2 NADH
ReactionCard
Thumb+Thumb+Thumb ↔ Thumb+Thumb+Thumb
L-Histidinal + Water + NAD ↔ L-Histidine + NADH + Hydrogen ion
ReactionCard
Thumb+Thumb ↔ Thumb+Thumb+Thumb
L-Histidinol + NAD ↔ L-Histidinal + NADH + Hydrogen ion
ReactionCard
Thumb+Thumb+2 Thumb → Thumb+2 Thumb
L-Histidinol + Water + 2 NAD → L-Histidine + 2 NADH
ReactionCard
Thumb+2 Thumb+Thumb ↔ Thumb+2 Thumb+3 Thumb
L-Histidinol + 2 NAD + Water ↔ L-Histidine + 2 NADH + 3 Hydrogen ion
ReactionCard
Thumb+Thumb → Thumb+Thumb+Histidinal
L-Histidinol + NAD → NADH + Hydrogen ion + Histidinal
ReactionCard
Thumb+Thumb+Histidinal → 2 Thumb+Thumb+L-Histidine+Thumb
Water + NAD + Histidinal → 2 Hydrogen ion + NADH + L-Histidine + L-Histidine
ReactionCard
Thumb
histidinal + NAD+ + H2O → L-histidine + NADH + 2 H+
ReactionCard
PAMDB110046+PAMDB110542+PAMDB000142 → PAMDB000074+PAMDB110540+PAMDB001633
histidinol + NAD+ + Water → L-Histidine + NADH + Hydrogen ion
ReactionCard
Complex Reactions:
Thumb+Thumb+2 Thumb → 3 Thumb+Thumb+2 Thumb
Water + L-Histidinol + 2 NAD → 3 Hydrogen ion + L-Histidine + 2 NADH
ReactionCard
Thumb+Thumb+2 Thumb → Thumb+2 Thumb
L-Histidinol + Water + 2 NAD → L-Histidine + 2 NADH
ReactionCard
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB001633Hydrogen ionMetaboCard
PAMDB001944L-HistidinalMetaboCard
PAMDB000074L-HistidineMetaboCard
PAMDB000502L-HistidinolMetaboCard
PAMDB000197NADMetaboCard
PAMDB000398NADHMetaboCard
PAMDB000142WaterMetaboCard
GO Classification:
Function
binding
catalytic activity
cation binding
histidinol dehydrogenase activity
ion binding
metal ion binding
NAD or NADH binding
nucleotide binding
oxidoreductase activity
oxidoreductase activity, acting on CH-OH group of donors
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
transition metal ion binding
zinc ion binding
Process
cellular amino acid and derivative metabolic process
cellular amino acid metabolic process
cellular metabolic process
histidine biosynthetic process
histidine family amino acid metabolic process
histidine metabolic process
metabolic process
oxidation reduction
Gene Properties
Locus tag: PA4448
Strand: -
Entrez Gene ID: 880992
Accession: NP_253138.1
GI: 15599644
Sequence start: 4982104
Sequence End: 4983426
Sequence Length: 1322
Gene Sequence: 
>PA4448
ATGACCGCTCCCTTCGCTATCCGTCGACTCAATGCCGCTGATCCGGACTTCGGGCGTCATCTGGATCATCTGCTGAGCTGGGAAAGTGTCTCCGACGATTCGGTCAACCAGCGCGTCCTCGACATCATCGCCGCCGTACGCAGCCGTGGCGACGCCGCCGTGGTCGAGTTCACCCAGCGCTTCGACGGTCTCCAGGCCGCCTCGATGGCCGACCTGATCCTGCCGCGCGAGCGCCTGGAGCTGGCTCTCACACGTATCACCGTAGCCCAGCGCGAAGCCCTGGAAGTCGCCGCCGAGCGCGTGCGCAGCTACCACGAGAAGCAGAAGCAGGGTTCCTGGCGCTACACCGAGGCCGACGGCACGGTGCTCGGCCAGCAGGTCACCCCGCTGGACCGCGCCGGGCTCTATGTGCCGGGCGGCAAGGCGTCCTACCCGTCCTCGGTGCTGATGAATGCGATCCCGGCCAAGGTCGCCGGGGTGTCCGAAGTGGTCATGGTTGTACCGACCCCGCGCGGCGAGATCAACGAGATCGTCCTCGCCGCCGCCTGCATCGCCGGCGTCGACCGTGTCTTCACCATCGGCGGGGCACAGGCCGTGGCCGCGTTGGCCTACGGCACCGAAAGCGTGCCGCGGGTGGACAAGATCGTCGGCCCCGGCAACATCTACGTGGCCACCGCCAAGCGTCACGTGTTCGGCCAGGTCGGCATCGACATGATCGCCGGTCCCTCGGAAATCCTCGTGGTCTGCGATGGCCAGACCGATCCCGACTGGATCGCCATGGACCTGTTCTCCCAGGCCGAACACGACGAAGACGCCCAGTCGATCCTGGTCAGTCCGGATGCGGCGTTCCTGGACCGCGTCGCGGACAGCATCGCTCGCCTGCTGCCGACCATGGAGCGCGCCGAGATCATCCGCACCTCCCTGGAGGGGCGCGGCGCGCTGATCCAGGTCGCCGACCAGGCCCAGGCCTGTGCGGTCGCCAACCGCATCGCCCCGGAACACCTGGAGCTGTCGGTGGCCGATCCGGAAAGCTGGCTGCCGGAGATCCGCCATGCCGGCGCGATCTTCATGGGCCGCTACACTGCCGAGGCCCTGGGCGACTATTGCGCCGGCCCGAACCACGTGCTGCCGACCTCCGGTACCGCGCGTTTCTCTTCGCCGCTGGGGGTATATGACTTCCAGAAGCGTTCGTCGATCATCAACTGCTCGGCCGAGGGCGCTTCGGTCCTCGGTCGTACCGCCTCGGTGCTGGCTCGCGGCGAGTCGTTGACCGCCCACGCGCGTAGTGCCGAATACCGCATCCTCGACGAGAAGGAGGCCTGA
Protein Properties
Protein Residues: 440
Protein Molecular Weight: 47.2 kDa
Protein Theoretical pI: 4.85
Hydropathicity (GRAVY score): 0.008
Charge at pH 7 (predicted): -13.97
Protein Sequence: 
>PA4448
MTAPFAIRRLNAADPDFGRHLDHLLSWESVSDDSVNQRVLDIIAAVRSRGDAAVVEFTQRFDGLQAASMADLILPRERLELALTRITVAQREALEVAAERVRSYHEKQKQGSWRYTEADGTVLGQQVTPLDRAGLYVPGGKASYPSSVLMNAIPAKVAGVSEVVMVVPTPRGEINEIVLAAACIAGVDRVFTIGGAQAVAALAYGTESVPRVDKIVGPGNIYVATAKRHVFGQVGIDMIAGPSEILVVCDGQTDPDWIAMDLFSQAEHDEDAQSILVSPDAAFLDRVADSIARLLPTMERAEIIRTSLEGRGALIQVADQAQACAVANRIAPEHLELSVADPESWLPEIRHAGAIFMGRYTAEALGDYCAGPNHVLPTSGTARFSSPLGVYDFQKRSSIINCSAEGASVLGRTASVLARGESLTAHARSAEYRILDEKEA
References
External Links:
Resource Link
Genome ID: PA4448
Entrez Gene ID: 880992
NCBI Protein ID: 15599644
General Reference: PaperBLAST - Find papers about PA4448 and its homologs