Identification |
Name: |
S-(hydroxymethyl)glutathione dehydrogenase |
Synonyms: |
- Alcohol dehydrogenase class-3
- Alcohol dehydrogenase class-III
- Glutathione-dependent formaldehyde dehydrogenase
- FALDH
- FDH
- GSH-FDH
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Gene Name: |
frmA |
Enzyme Class: |
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Biological Properties |
General Function: |
Involved in zinc ion binding |
Specific Function: |
Has high formaldehyde dehydrogenase activity in the presence of glutathione and catalyzes the oxidation of normal alcohols in a reaction that is not GSH-dependent. In addition, hemithiolacetals other than those formed from GSH, including omega-thiol fatty acids, also are substrates |
Cellular Location: |
Cytoplasm |
KEGG Pathways: |
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KEGG Reactions: |
| | | | |
Primary alcohol | + | | ↔ | Aldehyde | + | | + | |
| | | | | | |
trans-3-Chloro-2-propene-1-ol | + | | ↔ | trans-3-Chloroallyl aldehyde | + | | + | |
| | |
cis-3-Chloro-2-propene-1-ol | + | | ↔ | cis-3-Chloroallyl aldehyde | + | | + | |
| | | | | | |
Chloral hydrate | + | | + | | ↔ | Trichloroethanol | + | | + | |
| | | | | | | |
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SMPDB Reactions: |
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PseudoCyc/BioCyc Reactions: |
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Complex Reactions: |
| | |
| + | NAD(P)(+) | → | | + | NAD(P)H |
| | |
An alcohol | + | | → | an aldehyde or ketone | + | |
| |
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Transports: |
Not Available |
Metabolites: |
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GO Classification: |
Function |
---|
binding | catalytic activity | cation binding | ion binding | metal ion binding | oxidoreductase activity | oxidoreductase activity, acting on CH-OH group of donors | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | S-(hydroxymethyl)glutathione dehydrogenase activity | transition metal ion binding | zinc ion binding | Process |
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alcohol metabolic process | ethanol metabolic process | ethanol oxidation | metabolic process | monohydric alcohol metabolic process | oxidation reduction | small molecule metabolic process |
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Gene Properties |
Locus tag: |
PA3629 |
Strand: |
- |
Entrez Gene ID: |
880459 |
Accession: |
NP_252319.1 |
GI: |
15598825 |
Sequence start: |
4063875 |
Sequence End: |
4064987 |
Sequence Length: |
1112 |
Gene Sequence: |
>PA3629
ATGATCAAGTCCCGTGCCGCCGTCGCCTTCGCCCCCAACAAGCCGTTGGAAATCGTCGAGGTGGATGTGGCGCCGCCGCAGAAGGGCGAGGTACTGGTGCGCATCGTCGCCACCGGCGTCTGCCATACCGACGCGTACACCCTGTCCGGCCAGGATTCCGAGGGGGTGTTCCCGTGCATCCTGGGCCACGAAGGTGGCGGCATCGTCGAAGCGGTGGGCGAGGGCGTGACCTCCCTGCAGGTGGGCGACCATGTCATCCCGCTCTACACCGCCGAGTGCGGCAAGTGCAAATTCTGCCTGTCCGGCAAGACCAACCTCTGCCAGGCCGTGCGCGCCACCCAGGGCAAGGGCCTGATGCCCGACGGCACCAGCCGTTTCTCCTACAAGGGCGAGCCGGTCTTCCACTACATGGGCTGCTCGACCTTCTCCGAATACACCGTGCTGCCGGAAATCTCCCTGGCGAAGATTCCCAAGGATGCCCCGCTGGAGAAGGTCTGCCTGCTTGGCTGCGGCGTCACCACCGGGATCGGTGCCGTGCTGAACACCGCCAAGGTGGAAGAGGGCGCTACCGTTGCCATCTTCGGCCTGGGCGGCATCGGCCTGGCAGCGATCATCGGGGCGAAGATGGCCAAGGCCGCGCGCATCATCGCGGTCGACATCAACCCGGGCAAGTTCGATATCGCCAGGGAACTGGGCGCCACCGACTTCATCAATCCGAAGGACTACGACAAGCCGATCCAGGACGTCATCGTCGAACTGACCGATGGCGGCGTCGACTACTCCTTCGAGTGCGTCGGCAACGTGCAGTTGATGCGCGCCGCGCTGGAATGCTGCCACAAGGGCTGGGGCGAGTCGGTGATCATCGGTGTCGCCGGTGCCGGCCAGGAAATCAGCACCCGGCCGTTCCAACTGGTCACCGGCCGCGTCTGGCGCGGTTCGGCGTTCGGCGGGGTGCGCGGGCGCAGCGAGCTGCCGAGCTATGTCGAGAAGGCGCAGAAGGGCGAGATCCCGCTGGATACCTTCATCACCCACACCATGGGGCTGGAGGACATCAACGAGGCCTTCGAGCTGATGCACGAAGGCAAGAGCATCCGCACCGTCATTCATTACTGA |
Protein Properties |
Protein Residues: |
370 |
Protein Molecular Weight: |
39.2 kDa |
Protein Theoretical pI: |
5.44 |
Hydropathicity (GRAVY score): |
0.134 |
Charge at pH 7 (predicted): |
-7.43 |
Protein Sequence: |
>PA3629
MIKSRAAVAFAPNKPLEIVEVDVAPPQKGEVLVRIVATGVCHTDAYTLSGQDSEGVFPCILGHEGGGIVEAVGEGVTSLQVGDHVIPLYTAECGKCKFCLSGKTNLCQAVRATQGKGLMPDGTSRFSYKGEPVFHYMGCSTFSEYTVLPEISLAKIPKDAPLEKVCLLGCGVTTGIGAVLNTAKVEEGATVAIFGLGGIGLAAIIGAKMAKAARIIAVDINPGKFDIARELGATDFINPKDYDKPIQDVIVELTDGGVDYSFECVGNVQLMRAALECCHKGWGESVIIGVAGAGQEISTRPFQLVTGRVWRGSAFGGVRGRSELPSYVEKAQKGEIPLDTFITHTMGLEDINEAFELMHEGKSIRTVIHY |
References |
External Links: |
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General Reference: |
PaperBLAST - Find papers about PA3629 and its homologs
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