Sulfite reductase [NADPH] hemoprotein beta-component (PA1838)

Identification
Name: Sulfite reductase [NADPH] hemoprotein beta-component
Synonyms:
  • SiR-HP
  • SiRHP
Gene Name: cysI
Enzyme Class:
Biological Properties
General Function: Involved in sulfite reductase (NADPH) activity
Specific Function: Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate
Cellular Location: Not Available
KEGG Pathways:
KEGG Reactions:
5 Thumb+3 Thumb+Thumb ↔ 3 Thumb+Thumb+3 Thumb
5 Hydrogen ion + 3 NADPH + Sulfite ↔ 3 Water + Hydrogen sulfide + 3 NADP
ReactionCard
Thumb+Thumb+Thumb ↔ Thumb+Thumb
Flavin Mononucleotide + Hydrogen ion + NADPH ↔ FMNH + NADP
ReactionCard
Thumb+3 Thumb+3 Thumb ↔ Thumb+3 Thumb+3 Thumb
Hydrogen sulfide + 3 NADP + 3 Water ↔ Sulfite + 3 NADPH + 3 Hydrogen ion
ReactionCard
SMPDB Reactions:
3 NADPH+5 Thumb+Sulfite+3 Thumb+Thumb → Thumb+3 Thumb+3 Thumb
3 NADPH + 5 Hydrogen ion + Sulfite + 3 NADPH + Sulfite → Hydrogen sulfide + 3 Water + 3 NADP
ReactionCard
Sulfite+3 NADPH+5 Thumb+Thumb+3 Thumb → 3 Thumb+Thumb+Thumb
Sulfite + 3 NADPH + 5 Hydrogen ion + Sulfite + 3 NADPH → 3 Water + NADP + Hydrogen sulfide
ReactionCard
Thumb+Thumb+3 Thumb → Sulfite+3 NADPH+Thumb+3 Thumb
Sulfide + Water + 3 NADP → Sulfite + 3 NADPH + Sulfite + 3 NADPH
ReactionCard
Thumb+Thumb+2 Thumb → Riboflavin reduced+Thumb
Riboflavin + NADPH + 2 Hydrogen ion → Riboflavin reduced + NADP
ReactionCard
PseudoCyc/BioCyc Reactions:
5 Thumb+3 Thumb+Thumb ↔ 3 Thumb+Thumb+3 Thumb
5 Hydrogen ion + 3 NADPH + Sulfite ↔ 3 Water + Hydrogen sulfide + 3 NADP
ReactionCard
Thumb+Thumb+Thumb → Thumb+Thumb
Hydrogen ion + NADPH + Riboflavin → NADP + Reduced riboflavin
ReactionCard
Thumb+Thumb+Thumb ↔ Thumb+Thumb
Flavin Mononucleotide + Hydrogen ion + NADPH ↔ FMNH + NADP
ReactionCard
Complex Reactions:
Thumb+Thumb+Thumb → Thumb+Thumb
FAD + Hydrogen ion + NADPH → FADH2 + NADP
ReactionCard
Thumb+3 Thumb+3 Thumb → Thumb+3 Thumb
Hydrogen sulfide + 3 NADP + 3 Water → Sulfite + 3 NADPH
ReactionCard
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB000308FADMetaboCard
PAMDB000293FADH2MetaboCard
PAMDB000408Flavin MononucleotideMetaboCard
PAMDB000273FMNHMetaboCard
PAMDB001633Hydrogen ionMetaboCard
PAMDB000486Hydrogen sulfideMetaboCard
PAMDB000089NADPMetaboCard
PAMDB000615NADPHMetaboCard
PAMDB001686Reduced riboflavinMetaboCard
PAMDB000103RiboflavinMetaboCard
PAMDB000154SulfideMetaboCard
PAMDB000100SulfiteMetaboCard
PAMDB000142WaterMetaboCard
GO Classification:
Component
macromolecular complex
protein complex
sulfite reductase complex (NADPH)
Function
4 iron, 4 sulfur cluster binding
binding
catalytic activity
cation binding
heme binding
ion binding
iron ion binding
iron-sulfur cluster binding
metal cluster binding
metal ion binding
NADP or NADPH binding
nucleotide binding
oxidoreductase activity
oxidoreductase activity, acting on a sulfur group of donors, NAD or NADP as acceptor
oxidoreductase activity, acting on NADH or NADPH
sulfite reductase (NADPH) activity
transition metal ion binding
Process
cellular amino acid and derivative metabolic process
cellular amino acid biosynthetic process
cellular amino acid metabolic process
cellular metabolic process
metabolic process
oxidation reduction
Gene Properties
Locus tag: PA1838
Strand: -
Entrez Gene ID: 878581
Accession: NP_250529.1
GI: 15597035
Sequence start: 1995148
Sequence End: 1996806
Sequence Length: 1658
Gene Sequence: 
>PA1838
ATGTACGTATACGACGAGTACGACCAACGGATCGTCGAGGACCGCGTCAAGCAGTTCCGCGACCAGACCCGCCGTTACCTGGCGGGTGAATTGACCGGTGAGGAGTTCCGCCCGCTGCGCCTGCAGAACGGTCTCTATATCCAGCGCTATGCCCCGATGCTGCGCATCGCCGTTCCCTATGGCCTGCTCTCCTCGCGCCAACTGCGCAAGCTGGCGCAGATCGCCCGCGACTACGACAAGGGCTACGCCCACATCAGCACCCGGCAGAACGTGCAGTTCAACTGGCCGGAGCTGGAAGACGTGCCGGAAATCCTCGCCGAGCTGGCCACCGTGCAGATGCACGCGATTCAGACCAGCGGCAACTGCATCCGCAACACCACCACCGACCAGTTCGCCGGCGTCGCCCGCGACGAGCTGGTGGACCCGCGCCCCTGGTGCGAGATCATCCGCCAATGGTCGACCTTCCACCCCGAGTTCGCCCACCTGCCGCGCAAGTTCAAGATCGCGGTGAACGGCGCGGTGAGCGACCGTGCCGCCATCGAAGTGCACGACATCGGCCTGGAGGCGGTGAAGAACGAGGCCGGCGAGCTCGGCTTCCGCGTCTCGGTCGGCGGCGGCCTGGGCCGAACCCCCATCGTCGGCAGCTTCATCAATGAATTCCTGCCCTGGCAGCACCTGCTCGGCTACCTGGATGCCATCCTGCGCGTCTACAACCGCTATGGCCGGCGCGACAACAAGTACAAGGCGCGGATCAAGATCCTGGTCAAGGCGCTGACCCCGGAAGTCTTCGCCGAGCGCGTCGAGGCCGAATGGGCCAACCTCAAGGACGGACCGAGCACCCTCACCGAGGCGGAAGTCCAGCGCGTCGCCGCGCATTTCGTCGATCCGGCCTACAAGGCCCTCGACGACCTCGACGAGTCCCTCGCCCGGCTCGACGCGGAGCACCCCGGCTTCGCCCGCTGGCGCGCACGCAACACCTTCGCCCACAAGAAGCCCGGCTACGTCGCCGTGACGCTCTCGCTGAAGCCCACCGGCACCGCGCCGGGAGACGTCACCGACAAACAGCTGGAGGCCATCGCCGATCTCGCCGACCGCTACAGCTTCGGCGAGGTGCGCAACAGCCATAACCAGAACATCATTCTCGCCGACGTCGAGCAGGGCGAACTCTTCGCCCTCTGGGGCGAACTGCGCGAACTGGGCTTCGCCACCCCCAACGTCGGCCTGCTGACCGACATCATCTGCTGCCCCGGCGGCGACTTCTGCTCCCTGGCCAACGCCAAGTCGATCCCGATCGCCGAAGCCATCCAGCGCCGCTTCGACAATCTCGACTATCTATTCGACATCGGCGACATCGACCTGAACATCTCCGGTTGCATGAACGCCTGCGGCCATCACCATGTCGGCCACATCGGCATCCTCGGGGTCGACAAGAAAGGCGCGGAGTTCTACCAGGTCTCCCTCGGCGGCAGCTCGGCGCGCGACGCCAGCCTCGGGCAGATCCTCGGCCCGTCCTTCGCCCAGGAGCAGATGGCCGACGTGATCGACAAGATCATCCAGGTCTACGTGGAACGCCGGACCGAGGAAGAACCCTTCATCGACACCTTCCGCCGTATCGGTATCGACCCGTTCAAGGAGCGCGTATATGCAGCGAATCATTAA
Protein Properties
Protein Residues: 552
Protein Molecular Weight: 62.1 kDa
Protein Theoretical pI: 5.9
Hydropathicity (GRAVY score): -0.297
Charge at pH 7 (predicted): -9.58
Protein Sequence: 
>PA1838
MYVYDEYDQRIVEDRVKQFRDQTRRYLAGELTGEEFRPLRLQNGLYIQRYAPMLRIAVPYGLLSSRQLRKLAQIARDYDKGYAHISTRQNVQFNWPELEDVPEILAELATVQMHAIQTSGNCIRNTTTDQFAGVARDELVDPRPWCEIIRQWSTFHPEFAHLPRKFKIAVNGAVSDRAAIEVHDIGLEAVKNEAGELGFRVSVGGGLGRTPIVGSFINEFLPWQHLLGYLDAILRVYNRYGRRDNKYKARIKILVKALTPEVFAERVEAEWANLKDGPSTLTEAEVQRVAAHFVDPAYKALDDLDESLARLDAEHPGFARWRARNTFAHKKPGYVAVTLSLKPTGTAPGDVTDKQLEAIADLADRYSFGEVRNSHNQNIILADVEQGELFALWGELRELGFATPNVGLLTDIICCPGGDFCSLANAKSIPIAEAIQRRFDNLDYLFDIGDIDLNISGCMNACGHHHVGHIGILGVDKKGAEFYQVSLGGSSARDASLGQILGPSFAQEQMADVIDKIIQVYVERRTEEEPFIDTFRRIGIDPFKERVYAANH
References
External Links:
Resource Link
Genome ID: PA1838
Entrez Gene ID: 878581
NCBI Protein ID: 15597035
General Reference: PaperBLAST - Find papers about PA1838 and its homologs