Low specificity L-threonine aldolase (PA0902)

Identification
Name: Low specificity L-threonine aldolase
Synonyms:
  • Low specificity L-TA
Gene Name: ltaE
Enzyme Class:
Biological Properties
General Function: Involved in lyase activity
Specific Function: Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde. L-threo-phenylserine and L- erythro-phenylserine are also good substrates
Cellular Location: Not Available
KEGG Pathways:
KEGG Reactions:
Thumb ↔ Thumb+Thumb
L-Threonine ↔ Acetaldehyde + Glycine
ReactionCard
Thumb → Thumb+Thumb
L-Allothreonine → Acetaldehyde + Glycine
ReactionCard
SMPDB Reactions: Not Available
PseudoCyc/BioCyc Reactions:
Thumb ↔ Thumb+Thumb
L-Threonine ↔ Acetaldehyde + Glycine
ReactionCard
Thumb+Thumb → Thumb+Thumb
D-Alanine + Pyridoxal 5'-phosphate → Pyridoxamine 5'-phosphate + Pyruvic acid
ReactionCard
Thumb → Thumb+Thumb
L-Allothreonine → Acetaldehyde + Glycine
ReactionCard
Complex Reactions:
Thumb+Thumb → Thumb+Thumb
L-Alanine + Pyridoxal 5'-phosphate → Pyridoxamine 5'-phosphate + Pyruvic acid
ReactionCard
Thumb → Thumb+Thumb
L-Threonine → Glycine + Acetaldehyde
ReactionCard
Thumb → Thumb+Thumb
L-Allothreonine → Glycine + Acetaldehyde
ReactionCard
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB000217AcetaldehydeMetaboCard
PAMDB000333D-AlanineMetaboCard
PAMDB000046GlycineMetaboCard
PAMDB000063L-AlanineMetaboCard
PAMDB001426L-AllothreonineMetaboCard
PAMDB000068L-ThreonineMetaboCard
PAMDB000400Pyridoxal 5'-phosphateMetaboCard
PAMDB000420Pyridoxamine 5'-phosphateMetaboCard
PAMDB000102Pyruvic acidMetaboCard
GO Classification:
Function
binding
catalytic activity
cofactor binding
lyase activity
pyridoxal phosphate binding
Process
cellular amino acid and derivative metabolic process
cellular amino acid metabolic process
cellular metabolic process
metabolic process
Gene Properties
Locus tag: PA0902
Strand: +
Entrez Gene ID: 881903
Accession: NP_249593.1
GI: 15596099
Sequence start: 985692
Sequence End: 986696
Sequence Length: 1004
Gene Sequence: 
>PA0902
GTGCCTGTCATCGACCTGCGCAGCGACACCGTCACCCAGCCCACCGCCGGCATGCGCGAAGCCATGGCCGCGGCCGAACTGGGCGACGACGTCTATGGCGAGGACCCCACGGTCAACCGCCTGGAGGCCGAACTGGCGGCGCGCCTGGGCTTCGCCGCGGCGCTCTTCGTACCGACCGGGACCATGAGCAACCTGCTCGGATTGATGGCCCACTGCGAGCGCGGCGACGAATACATCGTCGGCCAGCAGGCGCATACCTACAAATACGAGGGCGGCGGTGCCGCGGTGCTGGGCTCGATCCAGCCGCAGCCGATCGACGGCGAGGCCGACGGATCGCTCCACCTGGACAAGGTCGCGGCGGCGATCAAGGCCGACGATTTCCACTTCGCCAGGACCCGCCTGCTGGCCCTGGAAAACACCATGCAGGGCAAGGTGCTGCCGCTCGACTACCTGGCCGCGGCGCGCGCCTTCACTCGCGCGCGTGGCCTGGCCCTGCACCTGGATGGCGCGCGCCTGTACAACGCGGCGGTGAAGCTGGGCGTAGACGCCAGCGAGATCACCCGACACTTCGACTCGGTGTCGGTGTGCCTGTCCAAGGGCCTCGGTGCGCCGGTGGGCTCGGTGCTTTGCGGCAGCGTCGAACTGATCGGCAAGGCCCGCCGCTGGCGCAAAATGGTCGGCGGCGGGATGCGCCAGGCCGGCCTGTTGGCGGCTGCCGGACTGTACGCCCTCGACCACCAGGTGGCACGCCTGGCCGACGACCACGCCAACGCCGCGCGCCTGGGCGACGGGCTGCGCGAACTGGGCTATGCGGTGGAGCCGGTGCAGACCAACATGGTCTACGTCGATGTCGGCGAGCGGGCGGTCGCGCTGCGCGACTTCCTCGCCGAGCGCGGGGTGCGGATCAGCGCGGCGGCGCGTTTGCGCCTGGTCACCCACCTGGACGTTTCCGCCGAGTCCATAGGACAAGTACTGGATGCCTTCGCGGCCTTTCGTCGCTCATAA
Protein Properties
Protein Residues: 334
Protein Molecular Weight: 35.4 kDa
Protein Theoretical pI: 6.43
Hydropathicity (GRAVY score): 0.08
Charge at pH 7 (predicted): -2.92
Protein Sequence: 
>PA0902
MPVIDLRSDTVTQPTAGMREAMAAAELGDDVYGEDPTVNRLEAELAARLGFAAALFVPTGTMSNLLGLMAHCERGDEYIVGQQAHTYKYEGGGAAVLGSIQPQPIDGEADGSLHLDKVAAAIKADDFHFARTRLLALENTMQGKVLPLDYLAAARAFTRARGLALHLDGARLYNAAVKLGVDASEITRHFDSVSVCLSKGLGAPVGSVLCGSVELIGKARRWRKMVGGGMRQAGLLAAAGLYALDHQVARLADDHANAARLGDGLRELGYAVEPVQTNMVYVDVGERAVALRDFLAERGVRISAAARLRLVTHLDVSAESIGQVLDAFAAFRRS
References
External Links:
Resource Link
Genome ID: PA0902
Entrez Gene ID: 881903
NCBI Protein ID: 15596099
General Reference: PaperBLAST - Find papers about PA0902 and its homologs