Dethiobiotin synthetase (PA0504)

Identification
Name: Dethiobiotin synthetase
Synonyms:
  • DTB synthetase
  • DTBS
  • Dethiobiotin synthase
Gene Name: bioD
Enzyme Class:
Biological Properties
General Function: Involved in magnesium ion binding
Specific Function: ATP + 7,8-diaminononanoate + CO(2) = ADP + phosphate + dethiobiotin
Cellular Location: Cytoplasm
KEGG Pathways:
KEGG Reactions:
Thumb+Thumb+Thumb ↔ Thumb+Thumb+3 Thumb+Thumb
Adenosine triphosphate + Carbon dioxide + 7,8-Diaminononanoate ↔ ADP + Dethiobiotin + 3 Hydrogen ion + Phosphate
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Thumb+Thumb+Thumb ↔ Thumb+Thumb+Thumb
Adenosine triphosphate + 7,8-Diaminononanoate + Carbon dioxide ↔ ADP + Phosphate + Dethiobiotin
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SMPDB Reactions:
7,8-Diaminononanoate+Thumb+Thumb+Thumb → Thumb+Adenosine diphosphate+Thumb+Thumb
7,8-Diaminononanoate + Adenosine triphosphate + Carbon dioxide + 7,8-Diaminononanoate → Dethiobiotin + Adenosine diphosphate + Phosphate + ADP
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PseudoCyc/BioCyc Reactions:
Thumb+Thumb+Thumb ↔ Thumb+Thumb+3 Thumb+Thumb
Adenosine triphosphate + Carbon dioxide + 7,8-Diaminononanoate ↔ ADP + Dethiobiotin + 3 Hydrogen ion + Phosphate
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Complex Reactions:
Thumb+Thumb+Thumb → Thumb+Thumb+Thumb
Adenosine triphosphate + 7,8-Diaminononanoate + Carbon dioxide → ADP + Inorganic phosphate + Dethiobiotin
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Thumb+Thumb+Thumb → Thumb+Thumb+Thumb
Adenosine triphosphate + 7,8-Diaminononanoate + Carbon dioxide → ADP + Inorganic phosphate + Dethiobiotin
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Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB0009577,8-DiaminononanoateMetaboCard
PAMDB000148Adenosine triphosphateMetaboCard
PAMDB000345ADPMetaboCard
PAMDB000568Carbon dioxideMetaboCard
PAMDB000517DethiobiotinMetaboCard
PAMDB001633Hydrogen ionMetaboCard
PAMDB001776Inorganic phosphateMetaboCard
PAMDB000383PhosphateMetaboCard
GO Classification:
Function
adenyl nucleotide binding
adenyl ribonucleotide binding
ATP binding
binding
catalytic activity
cation binding
cyclo-ligase activity
dethiobiotin synthase activity
ion binding
ligase activity
ligase activity, forming carbon-nitrogen bonds
magnesium ion binding
metal ion binding
nucleoside binding
purine nucleoside binding
Process
biotin biosynthetic process
biotin metabolic process
metabolic process
small molecule metabolic process
vitamin metabolic process
water-soluble vitamin metabolic process
Gene Properties
Locus tag: PA0504
Strand: +
Entrez Gene ID: 878220
Accession: NP_249195.1
GI: 15595701
Sequence start: 563549
Sequence End: 564235
Sequence Length: 686
Gene Sequence: 
>PA0504
ATGCCGGCGTTCTTCGTCACCGGTACCGACACCGAGATCGGCAAGACCACCATCGCCGCCGGCCTGCTCCACGCGGCCCGGAGTGCCGGCCTGAGCACCGCCGCGGCGAAGCCGGTGGCCTCCGGCTGCGAGCCCACGGCGCAAGGCCTGCGCAATGGCGACGCGTTGGTGTTGCTCGGCCAGTGCTCGCTGGCGCTGGCCTACGAGCAGGTCAACCCGCTGGCCTTCGCACCGGCCATCGCCCCGCACCTGGCGGCGCGCGAGGCTGGCGTCGAACTGAGCGCCGCACGCTTGCACGAGGCGGTGCGCGAGGTGCTGGCGCTACAGGCCGACTTCACCCTGGTGGAGGGCGCCGGCGGATGGCGCGTGCCGTTGCTGGGCCGCGAGAACCTGTCCGACCTGGCGCGCCTGCTGGCGCTGCCGGTGGTGCTGGTGGTCGGCGTGCGCCTGGGCTGTATCAACCATGCGCTGCTCAGCGCCGAGGCGATCCTGGGCGACGGCCTGGCGCTGGCCGGCTGGGTGGCCAACGTCGTCGACCCGGCTACCTCGCGCCTGGAAGAGAACCTGGCGACCCTCGCCGAACGCCTGCCGGCGCCCTGCCTGGGTCGGGTACCGCGCCTGGAGGAAGCCACTCCCGCGGCCGTGGCCGCGCACCTCGACCTGCGGCCCCTGGGTATCGGGCTATAA
Protein Properties
Protein Residues: 228
Protein Molecular Weight: 23.3 kDa
Protein Theoretical pI: 5.26
Hydropathicity (GRAVY score): 0.501
Charge at pH 7 (predicted): -4.92
Protein Sequence: 
>PA0504
MPAFFVTGTDTEIGKTTIAAGLLHAARSAGLSTAAAKPVASGCEPTAQGLRNGDALVLLGQCSLALAYEQVNPLAFAPAIAPHLAAREAGVELSAARLHEAVREVLALQADFTLVEGAGGWRVPLLGRENLSDLARLLALPVVLVVGVRLGCINHALLSAEAILGDGLALAGWVANVVDPATSRLEENLATLAERLPAPCLGRVPRLEEATPAAVAAHLDLRPLGIGL
References
External Links:
Resource Link
Genome ID: PA0504
Entrez Gene ID: 878220
NCBI Protein ID: 15595701
General Reference: PaperBLAST - Find papers about PA0504 and its homologs