Record Information
Version 1.0
Update Date 1/22/2018 12:54:54 PM
Metabolite IDPAMDB001776
Identification
Name: Inorganic phosphate
Description:Phosphates are important in biochemistry and biogeochemistry or ecology. In ecology, because of its important role in biological systems, phosphate is a highly sought after resource. Once used, it is often a limiting nutrient in environments, and its availability may govern the rate of growth of organisms. In biological systems, phosphorus is found as a free phosphate ion in solution and is called inorganic phosphate, to distinguish it from phosphates bound in various phosphate esters. Inorganic phosphate is generally denoted Pi, and at physiological (neutral) pH primarily consists of a mixture of HPO4(2-) and H2PO4(-) ions. Phosphates in cells are most commonly found in the form of adenosine phosphates (AMP, ADP and ATP) and in DNA and RNA and can be released by the hydrolysis of ATP or ADP. In addition, the addition and removal of phosphate from proteins in all cells (by kinases and phosphatases) is a pivotal strategy in the regulation of metabolic processes. (Wikipedia) Because the addition and removal of phosphates to and from biochemical compounds is so common, inorganic phosphate (Pi) is involved in a huge number of reactions in Pseudomonas aeruginosa. Also, many Pseudomonas aeruginosa enzymes are activated or inhibited by phosphate. (EcoCyc) Some processes that phosphates (Pi) are involved with in Pseudomonas aeruginosa are oxidative phosphorylation, where a phosphate is added to ADP to make ATP, and biosynthesis of peptidoglycan, a component of bacterial cell walls. (KEGG)
Structure
Thumb
Synonyms:
  • HPO4-2
  • HPO42-
  • HPO4-2
  • HPO42-
  • Inorganic phosphate
  • Inorganic phosphoric acid
  • NFB Orthophosphate
  • NFB Orthophosphoric acid
  • O-Phosphate
  • O-Phosphorate
  • O-Phosphoric acid
  • Ortho-phosphate
  • ortho-Phosphoric acid
  • Orthophosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
  • Orthophosphorate
  • Orthophosphoric acid
  • Orthophosphoric acid (PO43-)
  • Orthophosphoric acid(3-)
  • Phosphate
  • Phosphate (NF)
  • Phosphate (PO43-)
  • Phosphate anion(3-)
  • PHOSPHATE ION
  • Phosphate ion (PO43-)
  • Phosphate ion(3-)
  • Phosphate trianion
  • Phosphate(3-)
  • Phosphate-inorganic
  • Phosphorate
  • Phosphorate (NF)
  • Phosphorate ion(3-)
  • Phosphoric acid
  • Phosphoric acid (NF)
  • Phosphoric acid (PO43-)
  • Phosphoric acid anion(3-)
  • PHOSPHoric acid ion
  • Phosphoric acid ion (PO43-)
  • Phosphoric acid ion(3-)
  • Phosphoric acid trianion
  • Phosphoric acid(3-)
  • Phosphoric acid-inorganic
  • Pi
  • PO43
  • PO43-
  • PO43-
  • Tetraoxidophosphate(3)
  • Tetraoxidophosphoric acid(3)
  • Tetraoxophosphate(3)
  • Tetraoxophosphate(5)
  • Tetraoxophosphoric acid(3)
  • Tetraoxophosphoric acid(5)
  • [PO4]3
Chemical Formula: H3O4P
Average Molecular Weight: 97.9952
Monoisotopic Molecular Weight: 97.976895096
InChI Key: NBIIXXVUZAFLBC-UHFFFAOYSA-N
InChI:InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)
CAS number: 14265-44-2
IUPAC Name:phosphoric acid
Traditional IUPAC Name: phosphoric acid
SMILES:OP(O)(O)=O
Chemical Taxonomy
Taxonomy DescriptionThis compound belongs to the class of inorganic compounds known as non-metal phosphates. These are inorganic non-metallic compoundscontaining a phosphate as its largest oxoanion.
Kingdom Inorganic compounds
Super ClassHomogeneous non-metal compounds
Class Non-metal oxoanionic compounds
Sub ClassNon-metal phosphates
Direct Parent Non-metal phosphates
Alternative Parents
Substituents
  • Non-metal phosphate
  • Inorganic oxide
  • Acyclic compound
Molecular Framework Acyclic compounds
External Descriptors
Physical Properties
State: Solid
Charge:-2
Melting point: Not Available
Experimental Properties:
PropertyValueSource
Predicted Properties
PropertyValueSource
logP-1ChemAxon
pKa (Strongest Acidic)1.8ChemAxon
Physiological Charge-2ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count3ChemAxon
Polar Surface Area77.76 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity14.65 m3·mol-1ChemAxon
Polarizability5.81 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Biological Properties
Cellular Locations: Cytoplasm
Reactions:
Adenosine triphosphate + Acetyl-CoA + Carbonic acid > ADP + Inorganic phosphate + Malonyl-CoA
Adenosine triphosphate + biotin-[carboxyl-carrier-protein] + Carbon dioxide > ADP + Inorganic phosphate + carboxy-biotin-[carboxyl-carrier-protein]
An acylphosphate + Water > a carboxylate + Inorganic phosphate
Adenosine triphosphate + Water + monosaccharide(Out) > ADP + Inorganic phosphate + monosaccharide(In)
A phosphate monoester + Water > an alcohol + Inorganic phosphate
N-Acetyl-L-glutamate 5-semialdehyde + NADP + Inorganic phosphate > N-Acetyl-L-glutamyl 5-phosphate + NADPH
Phosphoenolpyruvic acid + Shikimate 3-phosphate > Inorganic phosphate + 5-O-(1-Carboxyvinyl)-3-phosphoshikimate
2-Dehydro-3-deoxy-D-arabino-heptonate 7-phosphate > 3-Dehydroquinate + Inorganic phosphate
5-O-(1-Carboxyvinyl)-3-phosphoshikimate > Chorismate + Inorganic phosphate
Phosphoenolpyruvic acid + D-Erythrose 4-phosphate + Water > 2-Dehydro-3-deoxy-D-arabino-heptonate 7-phosphate + Inorganic phosphate
Adenosine triphosphate + Water + K(+)(Out) > ADP + Inorganic phosphate + K(+)(In)
Adenosine triphosphate + Water + Mg(2+)(Out) > ADP + Inorganic phosphate + Mg(2+)(In)
Adenosine triphosphate + Water + H(+)(In) > ADP + Inorganic phosphate + H(+)(Out)
Adenosine triphosphate + Water + Cd(2+)(In) > ADP + Inorganic phosphate + Cd(2+)(Out)
Adenosine triphosphate + Water + Zn(2+)(In) > ADP + Inorganic phosphate + Zn(2+)(Out)
Adenosine triphosphate + 7,8-Diaminononanoate + Carbon dioxide > ADP + Inorganic phosphate + Dethiobiotin
Adenosine triphosphate + Water + vitamin B12(Out) > ADP + Inorganic phosphate + vitamin B12(In)
Inorganic phosphate + Oxalacetic acid > Water + Phosphoenolpyruvic acid + Carbonic acid
2 Adenosine triphosphate + L-Glutamine + Carbonic acid + Water >2 ADP + Inorganic phosphate + L-Glutamate + Carbamoylphosphate
Adenosine triphosphate + Water + heme(In) > ADP + Inorganic phosphate + heme(Out)
Adenosylcobalamin + Water > Adenosylcobalamin + Inorganic phosphate
Adenosine triphosphate + Water + Cu(+)(In) > ADP + Inorganic phosphate + Cu(+)(Out)
A 3'-ribonucleotide + Water > a ribonucleoside + Inorganic phosphate
Adenosine triphosphate + Water + sulfate(Out) > ADP + Inorganic phosphate + sulfate(In)
Adenosine 3',5'-diphosphate + Water > Adenosine monophosphate + Inorganic phosphate
Adenosine triphosphate + Water > ADP + Inorganic phosphate
Adenosine triphosphate + 2 D-Alanine > ADP + Inorganic phosphate + D-Alanyl-D-alanine
Purine nucleoside + Inorganic phosphate > Purine + Ribose-1-phosphate
Protein tyrosine phosphate + Water > protein tyrosine + Inorganic phosphate
Fructose 1,6-bisphosphate + Water > Fructose 6-phosphate + Inorganic phosphate
Adenosine triphosphate + Water + Fe(3+)(Out) > ADP + Inorganic phosphate + Fe(3+)(In)
Adenosine triphosphate + Water + iron chelate(Out) > ADP + Inorganic phosphate + iron chelate(In)
Adenosine triphosphate + tetrahydropteroyl-(gamma-Glu)(n) + L-Glutamate > ADP + Inorganic phosphate + tetrahydropteroyl-(gamma-Glu)(n+1)
Adenosine triphosphate + 7,8-Dihydropteroic acid + L-Glutamate > ADP + Inorganic phosphate + Dihydrofolic acid
D-Glyceraldehyde 3-phosphate + Inorganic phosphate + NAD > 3-phospho-D-glyceroyl phosphate + NADH
Adenosine triphosphate + L-Glutamate + Ammonia > ADP + Inorganic phosphate + L-Glutamine
Phosphoglycolic acid + Water > Glycolic acid + Inorganic phosphate
Guanosine 3'-diphosphate 5'-triphosphate + Water > Guanosine 3',5'-bis(diphosphate) + Inorganic phosphate
Adenosine triphosphate + L-Glutamate + L-Cysteine > ADP + Inorganic phosphate + gamma-Glutamylcysteine
Adenosine triphosphate + gamma-Glutamylcysteine + Glycine > ADP + Inorganic phosphate + Glutathione
Glutathione + Spermidine + Adenosine triphosphate > Glutathionylspermidine + ADP + Inorganic phosphate
Histidinol phosphate + Water > L-Histidinol + Inorganic phosphate
Pyrophosphate + Water >2 Inorganic phosphate
Phosphoenolpyruvic acid + D-Arabinose 5-phosphate + Water > 3-Deoxy-D-manno-octulosonate 8-phosphate + Inorganic phosphate
3-Deoxy-D-manno-octulosonate 8-phosphate + Water > 3-Deoxy-D-manno-octulosonate + Inorganic phosphate
Guanosine triphosphate + Water > Guanosine diphosphate + Inorganic phosphate
Adenosine triphosphate + Water + D-Maltose > ADP + Inorganic phosphate + D-Maltose
Adenosine triphosphate + Water + xenobiotic(In) > ADP + Inorganic phosphate + xenobiotic(Out)
Dihydroxyacetone phosphate > Pyruvaldehyde + Inorganic phosphate
Adenosine triphosphate + Water + Molybdate > ADP + Inorganic phosphate + Molybdate
2(alpha-D-mannosyl)-3-phosphoglycerate + Water > 2(alpha-D-Mannosyl)-D-glycerate + Inorganic phosphate
Phosphoenolpyruvic acid + Uridine diphosphate-N-acetylglucosamine > Inorganic phosphate + UDP-N-Acetyl-3-(1-carboxyvinyl)-D-glucosamine
Adenosine triphosphate + UDP-N-Acetylmuraminate + L-Alanine > ADP + Inorganic phosphate + UDP-N-Acetylmuramoyl-L-alanine
Adenosine triphosphate + UDP-N-Acetylmuramoyl-L-alanyl-gamma-D-glutamyl-L-lysine + D-Alanyl-D-alanine > ADP + Inorganic phosphate + UDP-N-Acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine
Dihydroxyacetone phosphate + Iminoaspartic acid > Quinolinic acid +2 Water + Inorganic phosphate
A 5'-ribonucleotide + Water > a ribonucleoside + Inorganic phosphate
A nucleoside triphosphate + Water > a nucleoside diphosphate + Inorganic phosphate
Adenosine triphosphate + Water + Ni(2+)(Out) > ADP + Inorganic phosphate + Ni(2+)(In)
Adenosine triphosphate + Water + Nickel > ADP + Inorganic phosphate + Nickel
ADP + (6S)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide > Adenosine monophosphate + Inorganic phosphate + NADH
Carbamoylphosphate + Ornithine > Inorganic phosphate + Citrulline
Trehalose 6-phosphate + Water > Trehalose + Inorganic phosphate
Phosphatidylglycerophosphate + Water > phosphatidylglycerol + Inorganic phosphate
1,2-diacyl-sn-glycerol 3-diphosphate + Water > 1,2-diacyl-sn-glycerol 3-phosphate + Inorganic phosphate
A 1,2-diacylglycerol 3-phosphate + Water > a 1,2-diacyl-sn-glycerol + Inorganic phosphate
Adenosine triphosphate + Water + phosphonate(Out) > ADP + Inorganic phosphate + phosphonate(In)
Acyl-[acyl-carrier-protein] + Inorganic phosphate > acyl-phosphate + [acyl-carrier-protein]
RNA(n+1) + Inorganic phosphate > RNA(n) + a nucleoside diphosphate
Adenosine triphosphate + Water + polyamine(Out) > ADP + Inorganic phosphate + polyamine(In)
Adenosine triphosphate + Pyruvic acid + Water > Adenosine monophosphate + Phosphoenolpyruvic acid + Inorganic phosphate
(Polyphosphate)(n) + Water > (polyphosphate)(n-1) + Inorganic phosphate
L-Glutamic-gamma-semialdehyde + Inorganic phosphate + NADP > L-Glutamic acid 5-phosphate + NADPH
A phosphoprotein + Water > a protein + Inorganic phosphate
[Pyruvate, water dikinase] phosphate + Inorganic phosphate > [pyruvate, water dikinase] + Pyrophosphate
Adenosine triphosphate + Water + phosphate(Out) > ADP + Inorganic phosphate + phosphate(In)
Adenosine triphosphate + 5-Phosphoribosylamine + Glycine > ADP + Inorganic phosphate + 5'-Phospho-ribosylglycinamide
Adenosine triphosphate + 2-(Formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine > ADP + Inorganic phosphate + 5-Aminoimidazole ribonucleotide
Adenosine triphosphate + 5-Amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-Aspartic acid > ADP + Inorganic phosphate + SAICAR
Adenosine triphosphate + 5-Aminoimidazole ribonucleotide + Carbonic acid > ADP + Inorganic phosphate + 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole
Adenosine triphosphate + L-Glutamate + Putrescine > ADP + Inorganic phosphate + gamma-Glutamyl-L-putrescine
Carbamoylphosphate + L-Aspartic acid > Inorganic phosphate + Ureidosuccinic acid
Adenosine triphosphate + Uridine triphosphate + Ammonia > ADP + Inorganic phosphate + Cytidine triphosphate
7-Deaza-7-carboxyguanine + Ammonia + Adenosine triphosphate > 7-Cyano-7-carbaguanine + ADP + Inorganic phosphate + Water
tRNA(n+1) + Inorganic phosphate > tRNA(n) + a nucleoside diphosphate
L-seryl-tRNA(Sec) + Phosphoroselenoic acid > L-selenocysteinyl-tRNA(Sec) + Inorganic phosphate
Adenosine triphosphate + Hydrogen selenide + Water > Adenosine monophosphate + Phosphoroselenoic acid + Inorganic phosphate
5-Methylaminomethyl-2-thiouridine + Phosphoroselenoic acid > 5-Methylaminomethyl-2-selenouridine + Inorganic phosphate
O-Phospho-D-serine + Water > L-Serine + Inorganic phosphate
Myo-inositol phosphate + Water > Myoinositol + Inorganic phosphate
Sugar phosphate + Water > Sucrose + Inorganic phosphate
Adenosine triphosphate + Water + Taurine > ADP + Inorganic phosphate + Taurine
O-Phosphohomoserine + Water > L-Threonine + Inorganic phosphate
Uridine + Inorganic phosphate > Uracil + Ribose-1-phosphate
Adenosine triphosphate + Water + Glycerol 3-phosphate > ADP + Inorganic phosphate + Glycerol 3-phosphate
Pyridoxal 5'-phosphate + Water > Pyridoxal + Inorganic phosphate
2-Deoxy-D-glucose 6-phosphate + Water > 2-Deoxyglucose + Inorganic phosphate
More...

Pathways: Not Available
Spectra
Spectra:
Spectrum TypeDescriptionSplash Key
GC-MSGC-MS Spectrum - GC-MS (3 TMS)splash10-0002-0794000000-6c866e626b9356994d46View in MoNA
GC-MSGC-MS Spectrum - GC-MSNot Available
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 10V, N/A (Annotated)splash10-000t-9000000000-0e85f764ac98e8949759View in MoNA
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 25V, N/A (Annotated)splash10-001i-9000000000-869a362083996a0cec77View in MoNA
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 40V, N/A (Annotated)splash10-03di-9000000000-801101cccfd6c25271d4View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
References
References:
  • Faiman C, Moorhouse JA: Diurnal variation in the levels of glucose and related substances in healthy and diabetic subjects during starvation. Clin Sci. 1967 Feb;32(1):111-26. Pubmed: 5336272
Synthesis Reference: Not Available
Material Safety Data Sheet (MSDS) Not Available
External Links:
ResourceLink
CHEBI ID18367
HMDB IDHMDB01429
Pubchem Compound ID1061
Kegg IDC00009
ChemSpider ID979
WikipediaPhosphate
BioCyc IDPi
EcoCyc IDPi
Ligand ExpoPO4