Glutathione synthetase (PA0407)

Identification
Name: Glutathione synthetase
Synonyms:
  • GSH synthetase
  • GSH-S
  • GSHase
  • Glutathione synthase
Gene Name: gshB
Enzyme Class:
Biological Properties
General Function: Involved in ATP binding
Specific Function: ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione
Cellular Location: Not Available
KEGG Pathways:
KEGG Reactions:
Thumb+Thumb+Thumb ↔ Thumb+Thumb+Thumb+Thumb
Adenosine triphosphate + gamma-Glutamylcysteine + Glycine ↔ ADP + Glutathione + Hydrogen ion + Phosphate
ReactionCard
Thumb+Thumb+Thumb ↔ Thumb+Thumb+Thumb
Adenosine triphosphate + gamma-Glutamylcysteine + Glycine ↔ ADP + Phosphate + Glutathione
ReactionCard
SMPDB Reactions:
Thumb+Thumb+Thumb → Thumb+Thumb+Adenosine diphosphate+Thumb+Thumb
gamma-Glutamylcysteine + Glycine + Adenosine triphosphate → Hydrogen ion + Phosphate + Adenosine diphosphate + Glutathione + ADP
ReactionCard
PseudoCyc/BioCyc Reactions:
Thumb+Thumb+Thumb ↔ Thumb+Thumb+Thumb+Thumb
Adenosine triphosphate + gamma-Glutamylcysteine + Glycine ↔ ADP + Glutathione + Hydrogen ion + Phosphate
ReactionCard
Complex Reactions:
Thumb+Thumb+Thumb → Thumb+Thumb+Thumb
Adenosine triphosphate + gamma-Glutamylcysteine + Glycine → ADP + Inorganic phosphate + Glutathione
ReactionCard
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB000148Adenosine triphosphateMetaboCard
PAMDB000345ADPMetaboCard
PAMDB000232gamma-GlutamylcysteineMetaboCard
PAMDB000048GlutathioneMetaboCard
PAMDB000046GlycineMetaboCard
PAMDB001633Hydrogen ionMetaboCard
PAMDB001776Inorganic phosphateMetaboCard
PAMDB000383PhosphateMetaboCard
GO Classification:
Function
acid-amino acid ligase activity
adenyl nucleotide binding
adenyl ribonucleotide binding
ATP binding
binding
catalytic activity
glutathione synthase activity
ligase activity
ligase activity, forming carbon-nitrogen bonds
nucleoside binding
purine nucleoside binding
Process
cellular metabolic process
glutathione biosynthetic process
glutathione metabolic process
metabolic process
peptide metabolic process
Gene Properties
Locus tag: PA0407
Strand: -
Entrez Gene ID: 878223
Accession: NP_249098.1
GI: 15595604
Sequence start: 448431
Sequence End: 449384
Sequence Length: 953
Gene Sequence: 
>PA0407
ATGAGCGTACGCCTCGGGATCGTCATGGACCCCATCGCGCGCATCAACTTCAAGAAGGACAGCTCGCTCGCCATGCTGCTGGCTGCCCAGGCCCGCGGCTGGTCGCTGTTCTACATGGAACAGCAGGACCTCTACCAGAAGGCCGGCGTCGCGCGTGGACGCATGCGCCCGCTGAAGGTCTTCAACGATGCCTCCCGCTGGTTCGAACTGGAAGCGGAAAGCGACCAACCGCTGCACGAACTGGACGTGATCCTGATGCGCAAGGACCCGCCCTTCGATAACGAATTCGTCTATTCGACCTACCTGCTGGAACAGGCCGAGCGTGCCGGCGCCCTGGTGGTGAACCGGCCGCAGAGCCTGCGCGACTGCAACGAGAAGTTCTTCGCCACGCAGTTCACCCAGTGCACTCCGCCGACGATGGTCAGCCGGCGATCCGATATTCTGCGCGAGTTTGCCGCCGAGCATCGTGACATCATTCTCAAACCCCTGGACGGAATGGGCGGTTCGTCGATATTTCGTCACCGCGAAGGCGACCCGAACCTCTCGGTGATCCTCGAGACCCTCACCCAGCATGGCAGCCAGCAGATCATGGCACAGCGCTATCTGCCGGAAATCAAGGACGGCGACAAGCGCATCCTGATGATCGACGGCGAACCGGTGCCCTACTGCCTGGCGCGCATCCCCGCCCAGGGCGAGACCCGCGGCAACCTCGCCGCCGGCGGCCGCGGCGTGGCCCAGCCGCTGAGCGAGCGCGACCGCTGGATCGCCGCCGAGGTCGGCCCGCACCTGCGCGAGCGCGGCCTGCTGTTCGTCGGCCTCGACGTGATCGGCGATTATCTGACGGAAATCAACGTCACCAGCCCGACCTGCATCCGCGAGATCGACCAGGCCTTCGACACCCGCATCGGCGACAAGCTGATGGACGCCATCGCCGCCCAGCTGGCTGCCCGCTGA
Protein Properties
Protein Residues: 317
Protein Molecular Weight: 35.7 kDa
Protein Theoretical pI: 5.76
Hydropathicity (GRAVY score): -0.282
Charge at pH 7 (predicted): -3.91
Protein Sequence: 
>PA0407
MSVRLGIVMDPIARINFKKDSSLAMLLAAQARGWSLFYMEQQDLYQKAGVARGRMRPLKVFNDASRWFELEAESDQPLHELDVILMRKDPPFDNEFVYSTYLLEQAERAGALVVNRPQSLRDCNEKFFATQFTQCTPPTMVSRRSDILREFAAEHRDIILKPLDGMGGSSIFRHREGDPNLSVILETLTQHGSQQIMAQRYLPEIKDGDKRILMIDGEPVPYCLARIPAQGETRGNLAAGGRGVAQPLSERDRWIAAEVGPHLRERGLLFVGLDVIGDYLTEINVTSPTCIREIDQAFDTRIGDKLMDAIAAQLAAR
References
External Links:
Resource Link
Genome ID: PA0407
Entrez Gene ID: 878223
NCBI Protein ID: 15595604
General Reference: PaperBLAST - Find papers about PA0407 and its homologs