Reaction 21943

Reaction Details
Reaction: Thumb
2-oxoglutarate + a [2-oxoglutarate dehydrogenase E2 protein] N6-lipoyl-L-lysine + H+ → a [2-oxoglutarate dehydrogenase E2 protein] N6-S-succinyldihydrolipoyl-L-lysine + CO2
Enzymes:
External Links:
ResourceLink
PseudoCyc Reaction ID:2OXOGLUTDECARB-RXN
References:
  • MASSEY V (1960). "The composition of the ketoglutarate dehydrogenase complex." Biochim Biophys Acta 38;447-60. PMID: 14422131
  • OCHOA S (1954). "Enzymic mechanisms in the citric acid cycle." Adv Enzymol Relat Subj Biochem 15;183-270. PMID: 13158180
  • Perham RN (2000). "Swinging arms and swinging domains in multifunctional enzymes: catalytic machines for multistep reactions." Annu Rev Biochem 69;961-1004. PMID: 10966480
  • SANADI DR, LITTLEFIELD JW, BOCK RM (1952). "Studies on alpha-ketoglutaric oxidase. II. Purification and properties." J Biol Chem 197(2);851-62. PMID: 12981117