P. aeruginosa Metabolome Database Protein PA3417

Identification

Name:

probable pyruvate dehydrogenase E1 component, alpha subunit

Synonyms:

Not Available

Gene Name:

Not Available

Enzyme Class:

Not Available

Biological Properties

General Function:

metabolic process

Specific Function:

oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor

Cellular Location:

Cytoplasmic

KEGG Pathways:

superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass GLYCOLYSIS-TCA-GLYOX-BYPASS
pyruvate fermentation to acetate and lactate I P41-PWY
pyruvate decarboxylation to acetyl CoA PYRUVDEHYD-PWY
anaerobic respiration ANARESP1-PWY
pyruvate fermentation to acetate II PWY-5482
lactate oxidation LCTACACAT-PWY

KEGG Reactions:

Not Available

SMPDB Reactions:

Not Available

PseudoCyc/BioCyc Reactions:

Ubiquinones

→

Ubiquinols

pyruvate + Water + Ubiquinones → Carbon dioxide + Ubiquinols + acetate
ReactionCard

glycine + a tetrahydrofolate + NAD⁺ → a 5,10-methylene-tetrahydrofolate + ammonium + CO₂ + NADH
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pyruvate + coenzyme A + NAD⁺ → acetyl-CoA + CO₂ + NADH
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pyruvate + lipoamide → S-acetyldihydrolipoamide + CO₂
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acetyl-CoA + dihydrolipoamide ← S-acetyldihydrolipoamide + coenzyme A
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2-oxoglutarate + coenzyme A + NAD⁺ → succinyl-CoA + CO₂ + NADH
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a [glycine-cleavage complex H protein] N⁶-aminomethyldihydrolipoyl-L-lysine + a tetrahydrofolate ↔ a [glycine-cleavage complex H protein] N⁶-dihydrolipoyl-L-lysine + a 5,10-methylene-tetrahydrofolate + ammonium
ReactionCard

glycine + a [glycine-cleavage complex H protein] N⁶-lipoyl-L-lysine + H⁺ ↔ a [glycine-cleavage complex H protein] N⁶-aminomethyldihydrolipoyl-L-lysine + CO₂
ReactionCard

succinyl-lipoate + coenzyme A → succinyl-CoA + DIHYDROLIPOYL-OXO-GLUT-E2
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a [lipoyl-carrier protein] N⁶-dihydrolipoyl-L-lysine + NAD⁺ = a [lipoyl-carrier protein]-N⁶-lipoyl-L-lysine + NADH + H⁺
ReactionCard

2-oxoglutarate + a [2-oxoglutarate dehydrogenase E2 protein] N⁶-lipoyl-L-lysine + H⁺ → a [2-oxoglutarate dehydrogenase E2 protein] N⁶-S-succinyldihydrolipoyl-L-lysine + CO₂
ReactionCard

→

acetate + Carbon dioxide + Hydrogen ion → pyruvate + Water
ReactionCard

Complex Reactions:

Not Available

Transports:

Not Available

Metabolites:

Not Available

GO Classification:

Function
oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
Process
metabolic process

Gene Properties

Locus tag:

PA3417

Strand:

Entrez Gene ID:

879876

Accession:

NP_252107.1

GI:

15598613

Sequence start:

3823509

Sequence End:

3824606

Sequence Length:

1097

Gene Sequence:

>PA3417
ATGGTTCACAACCGGATCGACCCGCCTTTCACCCGCTACCTCGACAGCGACGGTCGGCCCCTCGGCGAGTTGCCCGCCTGGGCCGGCGACAGCGATGCGCTGGTCGGCCTCTACCGGCAGATGCTCCTGACCCGCCTGTTCGACCAGAAGGCGGTGGCCCTCCAGCGTACCGGGCGGATCGGCACCTATGCGCCAACCCTCGGCCAGGAAGCCATCGGCGTGGCCATCGGCAGCCAGATGCGCGCCGAGGACGTGCTGGTGCCGTATTACCGCGATACCGCCGTGCAATTGATGCGCGGCGTGCGCATGGAGGACATCCTCCTCTACTGGGGCGGCGACGAGCGCGGCAGCGACTACGCCGAACCGCTGGCGGCGCAGGACTTTCCCATTTGCGTGCCGATCGCCACCCAGGCCCTGCATGCCTGCGGGGTCGCCTCGGCGTTCCGCATCCGCGGCGAACACCGGGTGGCGGTGACCACCTGCGGCGACGGCGCCACCAGCAAGGGCGATTTCCTCGAGGCGCTGAACGTGGCGGGCGCCTGGCAGTTGCCGGTGCTCTTCGTGGTCAACAACAACCAGTGGGCGATCTCGGTGCCGCGGCGCATCCAGTGCGGCGCGCCGACCCTGGCGGAGAAGGCGGTGGGTGCCGGCTTCCCCGGCGAACAGGTGGACGGCAACGACGTGCTGGCGGTCGCCGAACGCGTCCGCGCGGCCCTGGAGCGCGCGCGCCAGGGCAAGGGGCCGACCCTGCTGGAGTGCATCAGCTATCGCCTCTGCGACCACACCACGGCCGACGACGCCAGCCGCTACCGTTCCGCCGAGGAGGTCAACCAGGCCTGGCGCGAGGAGCCGATCAAGCGCCTGCGCGCCTTCCTCGCCGGCCGCGGCCAGTGGGACGAGGAGCGCGAGCAGGCGCTGGTGGGCGAGTGCCAGGCGCGGGTGCAGGAGGCGGTGGAGCGTTTCGAGACGTTCGCCGCGCAGGCGCCGCAGGCACTGTTCGAGCATGTCTACGCGCGCTGGCCGGCGGTCCTGGAGGAGCAGCGCGAGCAATTGCTGGAGCGCGCCGCGCGGCGGCGGGGAGGGGCCGAACATGAATGA

Protein Properties

Protein Residues:

365

Protein Molecular Weight:

40.4 kDa

Protein Theoretical pI:

5.2

Hydropathicity (GRAVY score):

-0.318

Charge at pH 7 (predicted):

-7.75

Protein Sequence:

>PA3417
MVHNRIDPPFTRYLDSDGRPLGELPAWAGDSDALVGLYRQMLLTRLFDQKAVALQRTGRIGTYAPTLGQEAIGVAIGSQMRAEDVLVPYYRDTAVQLMRGVRMEDILLYWGGDERGSDYAEPLAAQDFPICVPIATQALHACGVASAFRIRGEHRVAVTTCGDGATSKGDFLEALNVAGAWQLPVLFVVNNNQWAISVPRRIQCGAPTLAEKAVGAGFPGEQVDGNDVLAVAERVRAALERARQGKGPTLLECISYRLCDHTTADDASRYRSAEEVNQAWREEPIKRLRAFLAGRGQWDEEREQALVGECQARVQEAVERFETFAAQAPQALFEHVYARWPAVLEEQREQLLERAARRRGGAEHE

References

External Links:

Resource	Link
Genome ID:	PA3417
Entrez Gene ID:	879876
NCBI Protein ID:	15598613

General Reference:

PaperBLAST - Find papers about PA3417 and its homologs

probable pyruvate dehydrogenase E1 component, alpha subunit (PA3417)