Magnesium-transporting ATPase, P-type 1 (PA4825)

Identification
Name: Magnesium-transporting ATPase, P-type 1
Synonyms:
  • Mg(2+) transport ATPase, P-type 1
Gene Name: mgtA
Enzyme Class:
Biological Properties
General Function: Involved in hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
Specific Function: Mediates magnesium influx to the cytosol
Cellular Location: Cell inner membrane; Multi-pass membrane protein
KEGG Pathways:
    KEGG Reactions: Not Available
    SMPDB Reactions: Not Available
    PseudoCyc/BioCyc Reactions:
    Thumb+Thumb+Thumb → Thumb+Thumb+Thumb+Thumb
    Adenosine triphosphate + Water + Magnesium → ADP + Hydrogen ion + Magnesium + Phosphate
    ReactionCard
    Ni2++Thumb+Thumb → Ni2++Thumb+Thumb+Thumb
    Ni2+ + Adenosine triphosphate + Water → Ni2+ + ADP + Phosphate + Hydrogen ion
    ReactionCard
    Complex Reactions:
    Thumb+Thumb+Thumb → Thumb+Thumb+Thumb+Thumb
    Adenosine triphosphate + Water + Nickel → ADP + Hydrogen ion + Nickel + Phosphate
    ReactionCard
    Thumb+Thumb+Mg(2+)(Out) → Thumb+Thumb+Mg(2+)(In)
    Adenosine triphosphate + Water + Mg(2+)(Out) → ADP + Inorganic phosphate + Mg(2+)(In)
    ReactionCard
    Transports: Not Available
    Metabolites:
    PAMDB IDNameView
    PAMDB000148Adenosine triphosphateMetaboCard
    PAMDB000345ADPMetaboCard
    PAMDB001633Hydrogen ionMetaboCard
    PAMDB001776Inorganic phosphateMetaboCard
    PAMDB000149MagnesiumMetaboCard
    PAMDB001786NickelMetaboCard
    PAMDB000383PhosphateMetaboCard
    PAMDB000142WaterMetaboCard
    GO Classification:
    Component
    cell part
    integral to membrane
    intrinsic to membrane
    membrane
    membrane part
    Function
    adenyl nucleotide binding
    adenyl ribonucleotide binding
    ATP binding
    ATPase activity, coupled to transmembrane movement of ions
    ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism
    binding
    catalytic activity
    cation transmembrane transporter activity
    di-, tri-valent inorganic cation transmembrane transporter activity
    hydrolase activity
    hydrolase activity, acting on acid anhydrides
    hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
    inorganic cation transmembrane transporter activity
    ion transmembrane transporter activity
    magnesium ion transmembrane transporter activity
    magnesium-importing ATPase activity
    nucleoside binding
    purine nucleoside binding
    substrate-specific transmembrane transporter activity
    transmembrane transporter activity
    transporter activity
    Process
    ATP biosynthetic process
    cation transport
    cellular nitrogen compound metabolic process
    di-, tri-valent inorganic cation transport
    divalent metal ion transport
    establishment of localization
    ion transport
    magnesium ion transport
    metabolic process
    nitrogen compound metabolic process
    nucleobase, nucleoside and nucleotide metabolic process
    nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
    nucleoside phosphate metabolic process
    nucleotide metabolic process
    purine nucleoside triphosphate biosynthetic process
    purine nucleotide biosynthetic process
    purine nucleotide metabolic process
    purine ribonucleoside triphosphate biosynthetic process
    transport
    Gene Properties
    Locus tag: PA4825
    Strand: -
    Entrez Gene ID: 880401
    Accession: NP_253512.1
    GI: 15600018
    Sequence start: 5415413
    Sequence End: 5418124
    Sequence Length: 2711
    Gene Sequence: 
    >PA4825
ATGAGCGTAGCGACCCAACGCAATACCCAGCTCGATACCGAGCGCCGCAACGACCGACTGTCCATGCGCGCCGCCCGCGAAGCGCAGAACAGCCTGGAAACCACCCTCACCAATGTCCGCGGTCGCCAGGACGGCCTCGACCAGGCCGAGGCCGCCGCCCGGCTGCACGCCGACGGCCCCAACGAAGTGGCCCACGACCGTCCGCCACACGTCCTGGTGCAACTGCTGCAGGCGTTCAACAACCCCTTCATCTACGTGCTGATGACGCTCTCTGCGATCAGCTTCTTCACCGACTTCTGGCTGCCCCTGCAGGACGGTGAGGAAACCGATCTCACCGGCGTCATCATCGTCCTCTGCATGGTCCTGGTCAGCGGCCTGATGCGCTTCTGGCAGGAATACCGTTCGGGCAAGGCCGCCGAGGCGCTCAAGGCCATGGTGCGGAACACCGCCACCGTGCTGCGCCGCGACGAGCGCGGGATGCGCGGCGAGCTGCGGGAAATCCCCATGGGCGAACTGGTGGTCGGCGACATCGTGCGCCTGTCCGCCGGCGACATGATCCCCGCCGACATCCGCCTGATCGAATCGCGCGACCTGTTCATCAGCCAGGCCGTACTCACCGGCGAGGCGCTGCCGGTGGAGAAATACGACACCCTCGGCGCGGTCCGCGAGAAGTCCGCCAAGCGGATCGCCGCCGACCAGCAGGACCTGCTCGAACTGCCGAACATCTGCTTCATGGGCACCAACGTGGTCAGCGGCACGGCCACCGCGGTGGTGGTTGCCACCGGTGCGCGCACCTATTTCGGTTCGCTGGCCCGTTCCATCGTCGGTTCGCGGGCGCAGACCGCCTTCGACCGTGGGGTGAACAGCGTCAGTTGGCTGCTGATCCGCTTCATGCTGGTGATGGTGCCGATCGTGCTGCTGATCAACGGTTTCACCAAGGGCGACTGGACCGAGGCGTTCATGTTCGCTCTCGCCGTGGCGGTCGGCCTGACCCCGGAAATGCTGCCGATGATCGTCAGCGCCAACCTGGCCAAGGGCGCGGTGGCGATGTCGCGGCGCAAGGTGGTGGTCAAGCGCCTCAACGCGATCCAGAACTTCGGCGCCATGGACGTGCTCTGCACCGACAAGACCGGCACCCTGACCCAGGACCGGATCATCCTCGAGCATCACGTCGACGTTGCCGGCCGGCGCTGCGACCGGGTCCTGCAAATGGCCTGGCTGAACAGCTTCCACCAGTCCGGGATGAAGAACCTGATGGACCGCGCGGTGGTCGCCTTCGTCGAACAGAACCCGCGCATCACGCCGTCGGATGCCTGGCGCAAGGTCGACGAACTGCCCTTCGATTTCGTCCGTCGGCGTCTCTCGGTGATCCTCGAGGGCAAGGACGGCGAACAGCTGCTGGTGTGCAAGGGCGCGGTCGAGGAAATGCTCGAGATCGCCACCCGCGTGCACCAGGACGGTGTCGACCTGCCGCTCGACGAGGAACGCCGCCGGGCCCTGCTGGCGCTGGCCGAGCAATACAACCGCGACGGCTTCCGCGTGCTCCTGCTCGGCACCCGCAGCCTCTCGCGCACGGAGTCCCAGGCCCAGTACGGCGCCAGCGACGAGCGCGACCTGGTGATCGCCGGCCTGCTGACCTTCCTCGATCCACCGAAGGAAACCGCCGGCCCGGCCATCGCCGCGTTGCGCGAGAACGGCGTGGCAGTGAAGGTGCTCACCGGCGACAACCCGGTGGTCAGCGCGAAGATCTGCCGCGAGGTCGGCCTGGACGTCGGCGAGCCGCTGCTCGGTCGCGACATCGACCTGATGGACGATGCCACCCTGCAACGCCTGGCCGAGGAGCGCACGGTGTTCGCCAAGCTGACGCCGCTGCAGAAGTCGCGGGTGCTCAAGGCCCTGCAGGGCAACGGACACACCGTTGGCTTCCTCGGCGACGGCATCAACGACGCCCCCGCGCTGCGAGATGCCGATGTCGGCATCTCGGTGGACAGCGGCACCGACATCGCCAAGGAATCGGCCGACATCATCCTCCTGGAAAAAAGCCTGATGGTCCTGGAGGAGGGCGTTATCAAGGGCCGCGAGACCTTCGGCAACATCATGAAGTACCTGAACATGACTGCCAGCTCCAACTTCGGCAACGTGTTCTCGGTACTGGTGGCCAGCGCCTTCATCCCCTTCCTGCCGATGCTGGCGATCCACCTGCTGCTGCAGAACCTGATGTACGACATCTCCCAGCTGTCGCTGCCGTGGGACAAGATGGACAAGGAATTCCTCGCCAAGCCGCGCAAGTGGGACTCGAAGAACATCGGCCGCTTCATGGTCTGGATCGGCCCGACCTCGTCGATCTTCGACATCACCACCTACGCGCTGATGTGGTTCGTGTTCGCCGCCAACAGCCCGGAAATGCAGTCGCTGTTCCAGTCCGGCTGGTTCATCGAGGGCCTGCTCTCGCAGACCCTGGTGGTGCACATGCTGCGTACCCAGAAGATTCCCTTCATCCAGAGCACCGCGGCGCTGCCGGTGATGCTGATGACCGGGCTGGTGATGGCGCTGGGCATCTACGTGCCGTTCTCGCCGCTGGGAGCGGTGGTCGGCCTGCAGCCGCTGCCGTGGGAGTACTTCCCCTGGCTGGTGGGCACGCTGCTCTGCTACTGCGTCACCGCGCAGACCATGAAGACCCTCTACATCCGCCGCTTCGGCCAGTGGTTCTGA
    Protein Properties
    Protein Residues: 903
    Protein Molecular Weight: 100.1 kDa
    Protein Theoretical pI: 6.09
    Hydropathicity (GRAVY score): 0.118
    Charge at pH 7 (predicted): -5.78
    Protein Sequence: 
    >PA4825
MSVATQRNTQLDTERRNDRLSMRAAREAQNSLETTLTNVRGRQDGLDQAEAAARLHADGPNEVAHDRPPHVLVQLLQAFNNPFIYVLMTLSAISFFTDFWLPLQDGEETDLTGVIIVLCMVLVSGLMRFWQEYRSGKAAEALKAMVRNTATVLRRDERGMRGELREIPMGELVVGDIVRLSAGDMIPADIRLIESRDLFISQAVLTGEALPVEKYDTLGAVREKSAKRIAADQQDLLELPNICFMGTNVVSGTATAVVVATGARTYFGSLARSIVGSRAQTAFDRGVNSVSWLLIRFMLVMVPIVLLINGFTKGDWTEAFMFALAVAVGLTPEMLPMIVSANLAKGAVAMSRRKVVVKRLNAIQNFGAMDVLCTDKTGTLTQDRIILEHHVDVAGRRCDRVLQMAWLNSFHQSGMKNLMDRAVVAFVEQNPRITPSDAWRKVDELPFDFVRRRLSVILEGKDGEQLLVCKGAVEEMLEIATRVHQDGVDLPLDEERRRALLALAEQYNRDGFRVLLLGTRSLSRTESQAQYGASDERDLVIAGLLTFLDPPKETAGPAIAALRENGVAVKVLTGDNPVVSAKICREVGLDVGEPLLGRDIDLMDDATLQRLAEERTVFAKLTPLQKSRVLKALQGNGHTVGFLGDGINDAPALRDADVGISVDSGTDIAKESADIILLEKSLMVLEEGVIKGRETFGNIMKYLNMTASSNFGNVFSVLVASAFIPFLPMLAIHLLLQNLMYDISQLSLPWDKMDKEFLAKPRKWDSKNIGRFMVWIGPTSSIFDITTYALMWFVFAANSPEMQSLFQSGWFIEGLLSQTLVVHMLRTQKIPFIQSTAALPVMLMTGLVMALGIYVPFSPLGAVVGLQPLPWEYFPWLVGTLLCYCVTAQTMKTLYIRRFGQWF
    References
    External Links:
    Resource Link
    Genome ID: PA4825
    Entrez Gene ID: 880401
    NCBI Protein ID: 15600018
    General Reference: PaperBLAST - Find papers about PA4825 and its homologs