UDP-N-acetylmuramate--L-alanine ligase (PA4411)

Identification
Name: UDP-N-acetylmuramate--L-alanine ligase
Synonyms:
  • UDP-N-acetylmuramoyl-L-alanine synthetase
Gene Name: murC
Enzyme Class:
Biological Properties
General Function: Involved in ATP binding
Specific Function: Cell wall formation
Cellular Location: Cytoplasm (Probable)
KEGG Pathways:
KEGG Reactions:
Thumb+Thumb+Thumb ↔ Thumb+Thumb+Thumb+Thumb
L-Alanine + Adenosine triphosphate + UDP-N-Acetylmuraminate ↔ ADP + Hydrogen ion + Phosphate + UDP-N-Acetylmuramoyl-L-alanine
ReactionCard
Thumb+Thumb+Thumb ↔ Thumb+Thumb+Thumb
Adenosine triphosphate + UDP-N-Acetylmuraminate + L-Alanine ↔ ADP + Phosphate + UDP-N-Acetylmuramoyl-L-alanine
ReactionCard
SMPDB Reactions:
UDP-N-acetylmuraminate+Thumb+L-Alanine+Thumb+Thumb → Thumb+Adenosine diphosphate+Thumb+Thumb
UDP-N-acetylmuraminate + Adenosine triphosphate + L-Alanine + UDP-N-Acetylmuraminate + L-Alanine → UDP-N-Acetylmuramoyl-L-alanine + Adenosine diphosphate + Phosphate + ADP
ReactionCard
Thumb+L-Alanine+Thumb+Thumb → Adenosine diphosphate+Thumb+Thumb+Thumb+Thumb
UDP-N-acetyl-α-D-muramate + L-Alanine + Adenosine triphosphate + L-Alanine → Adenosine diphosphate + Phosphate + Hydrogen ion + UDP-N-Acetylmuramoyl-L-alanine + ADP
ReactionCard
Thumb+Thumb+Thumb → Thumb+Thumb+Thumb+Thumb
UDP-N-acetyl-α-D-muramate + Adenosine triphosphate + L-Alanine → UDP-N-Acetylmuramyl-L-Ala + ADP + Phosphate + Hydrogen ion
ReactionCard
PseudoCyc/BioCyc Reactions:
Thumb+Thumb+Thumb ↔ Thumb+Thumb+Thumb+Thumb
L-Alanine + Adenosine triphosphate + UDP-N-Acetylmuraminate ↔ ADP + Hydrogen ion + Phosphate + UDP-N-Acetylmuramoyl-L-alanine
ReactionCard
Thumb+Thumb+Thumb ↔ Thumb+Thumb+Thumb+Thumb
L-Alanine + UDP-N-Acetylmuraminate + Adenosine triphosphate ↔ Hydrogen ion + UDP-N-Acetylmuramoyl-L-alanine + Phosphate + ADP
ReactionCard
Complex Reactions:
Thumb+Thumb+Thumb → Thumb+Thumb+Thumb
Adenosine triphosphate + UDP-N-Acetylmuraminate + L-Alanine → ADP + Inorganic phosphate + UDP-N-Acetylmuramoyl-L-alanine
ReactionCard
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB000148Adenosine triphosphateMetaboCard
PAMDB000345ADPMetaboCard
PAMDB001633Hydrogen ionMetaboCard
PAMDB001776Inorganic phosphateMetaboCard
PAMDB000063L-AlanineMetaboCard
PAMDB000383PhosphateMetaboCard
PAMDB006355UDP-N-acetyl-α-D-muramateMetaboCard
PAMDB000485UDP-N-AcetylmuraminateMetaboCard
PAMDB000648UDP-N-Acetylmuramoyl-L-alanineMetaboCard
PAMDB001300UDP-N-Acetylmuramyl-L-AlaMetaboCard
GO Classification:
Component
cell part
cytoplasm
intracellular part
Function
acid-amino acid ligase activity
adenyl nucleotide binding
adenyl ribonucleotide binding
ATP binding
binding
catalytic activity
ligase activity
ligase activity, forming carbon-nitrogen bonds
nucleoside binding
purine nucleoside binding
UDP-N-acetylmuramate-L-alanine ligase activity
Process
aminoglycan metabolic process
biological regulation
biosynthetic process
carbohydrate metabolic process
cell division
cell wall biogenesis
cell wall organization or biogenesis
cellular cell wall organization or biogenesis
cellular component organization or biogenesis
cellular process
glycosaminoglycan metabolic process
metabolic process
peptidoglycan biosynthetic process
peptidoglycan metabolic process
peptidoglycan-based cell wall biogenesis
polysaccharide metabolic process
primary metabolic process
regulation of biological quality
regulation of cell shape
Gene Properties
Locus tag: PA4411
Strand: -
Entrez Gene ID: 881283
Accession: NP_253101.1
GI: 15599607
Sequence start: 4943633
Sequence End: 4945075
Sequence Length: 1442
Gene Sequence: 
>PA4411
GTGGTTAAAGAACCGAATGGCGTCACCCGGACCATGCGCCGTATCCGCCGCATCCATTTCGTCGGCATCGGCGGCGCCGGTATGTGCGGGATCGCCGAAGTGCTGCTGAACCTCGGCTACGAGGTATCCGGCTCGGACCTCAAGGCCTCGGCGGTGACCGAGCGCCTGGAGAAGTTCGGCGCGCAGATCTTCATCGGCCACCAGGCGGAAAACGCCGACGGCGCCGACGTGCTGGTGGTGTCCAGTGCCATCAACCGGGCCAACCCGGAAGTGGCATCGGCCCTGGAACGGCGGATTCCGGTGGTGCCGCGTGCGGAGATGCTCGCCGAGCTGATGCGCTACCGGCACGGCATCGCGGTAGCCGGCACCCACGGCAAGACCACCACTACCAGCCTGATCGCCTCGGTGTTCGCCGCCGGCGGCCTGGACCCGACCTTCGTCATCGGCGGCCGGCTGAACGCCGCCGGGACCAACGCCCAGCTCGGCGCCAGCCGCTACCTGGTGGCCGAGGCCGACGAGAGCGACGCCAGCTTCCTGCACCTGCAACCGATGGTCGCGGTGGTCACCAATATCGACGCCGACCACATGGCGACCTACGGCGGCGACTTCAACAAGCTGAAGAAGACCTTCGTCGAGTTCCTCCACAACCTGCCGTTCTACGGACTGGCGGTGATGTGCGTGGATGATCCGGTTGTGCGTGAGATCCTCCCGCAGATCGCCCGCCCGACCGTGACCTACGGCCTCAGCGAAGACGCCGACGTGCGCGCGATCAACATCCGCCAGGAAGGCATGCGCACCTGGTTCACCGTGTTGCGCCCGGAGCGCGAGCCGCTGGACGTCTCGGTGAACATGCCCGGCCTGCACAACGTGCTGAATTCCCTGGCGACCATCGTCATCGCTACCGACGAGGGCATCTCCGACGAAGCCATCGTCCAGGGGCTGTCCGGCTTCCAGGGCGTAGGCCGGCGCTTCCAGGTCTACGGCGAGCTGCAGGTCGAGGGTGGCAGCGTGATGCTGGTGGACGATTACGGCCACCATCCGCGCGAAGTCGCCGCGGTGATCAAGGCGATCCGTGGCGGTTGGCCGGAGCGTCGCCTGGTGATGGTCTACCAGCCGCATCGCTATACCCGTACCCGCGACCTGTACGAAGACTTCGTGCAGGTGCTGGGCGAAGCCAACGTGCTGCTGTTGATGGAGGTCTATCCGGCCGGCGAAGAGCCGATCCCGGGAGCCGACAGCCGCCAGCTGTGCCACAGCATCCGCCAGCGCGGCCAGCTTGACCCGATCTACTTCGAGCGCGACGCCGACCTGGCGCCGCTGGTCAAGCCGCTGCTGCGCGCTGGCGACATCCTGCTTTGCCAGGGCGCTGGCGATGTCGGCGGCCTGGCCCCGCAACTGATCAAGAACCCGCTGTTCGCCGGCAAGGGAGGGAAGGGCGCATGA
Protein Properties
Protein Residues: 480
Protein Molecular Weight: 51.9 kDa
Protein Theoretical pI: 6.1
Hydropathicity (GRAVY score): 0.013
Charge at pH 7 (predicted): -6.22
Protein Sequence: 
>PA4411
MVKEPNGVTRTMRRIRRIHFVGIGGAGMCGIAEVLLNLGYEVSGSDLKASAVTERLEKFGAQIFIGHQAENADGADVLVVSSAINRANPEVASALERRIPVVPRAEMLAELMRYRHGIAVAGTHGKTTTTSLIASVFAAGGLDPTFVIGGRLNAAGTNAQLGASRYLVAEADESDASFLHLQPMVAVVTNIDADHMATYGGDFNKLKKTFVEFLHNLPFYGLAVMCVDDPVVREILPQIARPTVTYGLSEDADVRAINIRQEGMRTWFTVLRPEREPLDVSVNMPGLHNVLNSLATIVIATDEGISDEAIVQGLSGFQGVGRRFQVYGELQVEGGSVMLVDDYGHHPREVAAVIKAIRGGWPERRLVMVYQPHRYTRTRDLYEDFVQVLGEANVLLLMEVYPAGEEPIPGADSRQLCHSIRQRGQLDPIYFERDADLAPLVKPLLRAGDILLCQGAGDVGGLAPQLIKNPLFAGKGGKGA
References
External Links:
Resource Link
Genome ID: PA4411
Entrez Gene ID: 881283
NCBI Protein ID: 15599607
General Reference: PaperBLAST - Find papers about PA4411 and its homologs