Mutator mutT protein (PA4400)

Identification
Name: Mutator mutT protein
Synonyms:
  • 7,8-dihydro-8-oxoguanine-triphosphatase
  • 8-oxo-dGTPase
  • dGTP pyrophosphohydrolase
Gene Name: mutT
Enzyme Class:
Biological Properties
General Function: Replication, recombination and repair
Specific Function: Involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine) from DNA and the nucleotide pool. 8-oxo-dGTP is inserted opposite dA and dC residues of template DNA with almost equal efficiency thus leading to A.T to G.C transversions. MutT specifically degrades 8-oxo-dGTP to the monophosphate
Cellular Location: Cytoplasmic
KEGG Pathways: Not Available
KEGG Reactions:
Thumb+Thumb → Thumb+Thumb+Thumb
Guanosine triphosphate + Water → Guanosine monophosphate + Hydrogen ion + Pyrophosphate
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Thumb+Thumb → Thumb+Thumb+Thumb
dGTP + Water → 2'-Deoxyguanosine 5'-monophosphate + Hydrogen ion + Pyrophosphate
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Thumb+Thumb ↔ Thumb+Thumb
8-oxo-dGTP + Water ↔ 8-oxo-dGMP + Pyrophosphate
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SMPDB Reactions: Not Available
PseudoCyc/BioCyc Reactions:
Thumb+Thumb → Thumb+Thumb+Thumb
Dihydroneopterin triphosphate + Water → Dihydroneopterin monophosphate + Hydrogen ion + Pyrophosphate
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Thumb+Thumb → Thumb+Thumb+Thumb
dGTP + Water → 2'-Deoxyguanosine 5'-monophosphate + Hydrogen ion + Pyrophosphate
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8-oxo-dGTP+Thumb → Thumb+8-oxo-dGMP+Thumb
8-oxo-dGTP + Water → Hydrogen ion + 8-oxo-dGMP + Pyrophosphate
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Complex Reactions:
Thumb+Thumb → Thumb+Thumb
8-oxo-dGTP + Water → 8-oxo-dGMP + Pyrophosphate
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Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB0002312'-Deoxyguanosine 5'-monophosphateMetaboCard
PAMDB0036248-oxo-dGMPMetaboCard
PAMDB0036238-oxo-dGTPMetaboCard
PAMDB000389dGTPMetaboCard
PAMDB001614Dihydroneopterin monophosphateMetaboCard
PAMDB000274Dihydroneopterin triphosphateMetaboCard
PAMDB000369Guanosine monophosphateMetaboCard
PAMDB000319Guanosine triphosphateMetaboCard
PAMDB001633Hydrogen ionMetaboCard
PAMDB000633PyrophosphateMetaboCard
PAMDB000142WaterMetaboCard
GO Classification:
Function
8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity
catalytic activity
hydrolase activity
hydrolase activity, acting on acid anhydrides
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
nucleoside-triphosphate diphosphatase activity
pyrophosphatase activity
Process
cellular macromolecule metabolic process
DNA metabolic process
DNA repair
macromolecule metabolic process
metabolic process
Gene Properties
Locus tag: PA4400
Strand: -
Entrez Gene ID: 881318
Accession: NP_253090.1
GI: 15599596
Sequence start: 4930748
Sequence End: 4931695
Sequence Length: 947
Gene Sequence: 
>PA4400
GTGAAACGAGTACATGTCGCCGCGGCCGTGATTCGTGGCTCCGATGGCCGGGTGCTGATCGCCCGGCGGCCGGAAGACAAGCACCAGGGCGGCCTGTGGGAGTTTCCCGGGGGCAAGGTGGAGGACGGCGAGCCGGTGCGCGCGGCGTTGGCCCGTGAGCTGGAAGAGGAACTGGGCATCCGTGTCGAGCGGGCCCGGCCGCTGATCCAGGTCCGGCACGACTATGCCGACAAGCACGTCCTGCTCGATGTCTGGGAGGTCGACGGGTTTTCCGGCGAAGCCCACGGCGCCGAGGGCCAACCGCTGGCCTGGGTGGAGCCGCGCGAGCTGGCCGACTACGAGTTCCCCGCCGCCAACGCGCCGATCGTCCAGGCCGCGCGCCTGCCGGCGCACTACCTGATCACCCCGGACGGATTGGAGCCGGGCGAGCTGATCAGCGGCGTACGCAAGGCGGTGGAGGCGGGCATCCGCCTGATCCAGTTGCGCGCGCCGAACATGTTCAGTCCCGAATACCGCGATCTCGCCATCGATATCCAGGGACTCTGCGCCGGCAAGGCGCAACTGATGCTGAAAGGCCCGCTGGAGTGGCTGGGCGACTTCCCGGCTGCCGGTTGGCACCTGACCTCCGCTCAACTGCGCAAATACGCCAGCGCCGGTCGGCCGTTCCCCGAAGGGCGCCTGCTGGCCGCCTCCTGCCACGACGCGGAGGAACTGGCCCTGGCTGCCTCGATGGGAGTGGAGTTCGTCACCCTTTCGCCGGTACAGCCGACCGAGAGCCATCCCGGCGAGCCGGCGCTGGGTTGGGACAAGGCCGCCGAACTGATCGCCGGCTTCAACCAGCCGGTCTACCTGCTGGGTGGCCTCGGTCCGCAGCAAGCCGAGCAGGCTTGGGAGCATGGAGCCCAGGGCGTGGCGGGTATCCGTGCGTTCTGGCCGGGCGGCCTTTGA
Protein Properties
Protein Residues: 315
Protein Molecular Weight: 34 kDa
Protein Theoretical pI: 5.11
Hydropathicity (GRAVY score): -0.169
Charge at pH 7 (predicted): -10.64
Protein Sequence: 
>PA4400
MKRVHVAAAVIRGSDGRVLIARRPEDKHQGGLWEFPGGKVEDGEPVRAALARELEEELGIRVERARPLIQVRHDYADKHVLLDVWEVDGFSGEAHGAEGQPLAWVEPRELADYEFPAANAPIVQAARLPAHYLITPDGLEPGELISGVRKAVEAGIRLIQLRAPNMFSPEYRDLAIDIQGLCAGKAQLMLKGPLEWLGDFPAAGWHLTSAQLRKYASAGRPFPEGRLLAASCHDAEELALAASMGVEFVTLSPVQPTESHPGEPALGWDKAAELIAGFNQPVYLLGGLGPQQAEQAWEHGAQGVAGIRAFWPGGL
References
External Links:
Resource Link
Genome ID: PA4400
Entrez Gene ID: 881318
NCBI Protein ID: 15599596
General Reference: PaperBLAST - Find papers about PA4400 and its homologs