1-deoxy-D-xylulose-5-phosphate synthase (PA4044)

Identification
Name: 1-deoxy-D-xylulose-5-phosphate synthase
Synonyms:
  • 1-deoxyxylulose-5-phosphate synthase
  • DXP synthase
  • DXPS
Gene Name: dxs
Enzyme Class:
Biological Properties
General Function: Involved in 1-deoxy-D-xylulose-5-phosphate synthase activity
Specific Function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Cellular Location: Not Available
KEGG Pathways:
KEGG Reactions:
Thumb+Thumb+Thumb ↔ Thumb+Thumb
D-Glyceraldehyde 3-phosphate + Hydrogen ion + Pyruvic acid ↔ Carbon dioxide + 1-Deoxy-D-xylulose 5-phosphate
ReactionCard
Thumb+Thumb ↔ Thumb+Thumb
Pyruvic acid + D-Glyceraldehyde 3-phosphate ↔ 1-Deoxy-D-xylulose 5-phosphate + Carbon dioxide
ReactionCard
SMPDB Reactions:
D-Glyceraldehyde 3-phosphate+Thumb+Thumb+Thumb → 1-Deoxy-D-xylulose 5-phosphate+Thumb+Thumb
D-Glyceraldehyde 3-phosphate + Pyruvic acid + Hydrogen ion + D-Glyceraldehyde 3-phosphate → 1-Deoxy-D-xylulose 5-phosphate + Carbon dioxide + 1-Deoxy-D-xylulose 5-phosphate
ReactionCard
D-Glyceraldehyde 3-phosphate+Thumb+Thumb → Thumb+1-Deoxy-D-xylulose 5-phosphate+Thumb
D-Glyceraldehyde 3-phosphate + Hydrogen ion + D-Glyceraldehyde 3-phosphate → Carbon dioxide + 1-Deoxy-D-xylulose 5-phosphate + 1-Deoxy-D-xylulose 5-phosphate
ReactionCard
D-Glyceraldehyde 3-phosphate+Thumb+Thumb → Thumb+1-Deoxy-D-xylulose 5-phosphate+Thumb
D-Glyceraldehyde 3-phosphate + Hydrogen ion + D-Glyceraldehyde 3-phosphate → Carbon dioxide + 1-Deoxy-D-xylulose 5-phosphate + 1-Deoxy-D-xylulose 5-phosphate
ReactionCard
Thumb+Thumb+Thumb → Thumb+Thumb
D-Glyceraldehyde 3-phosphate + Pyruvic acid + Hydrogen ion → 1-Deoxy-D-xylulose 5-phosphate + Carbon dioxide
ReactionCard
PseudoCyc/BioCyc Reactions:
Thumb+Thumb+Thumb ↔ Thumb+Thumb
D-Glyceraldehyde 3-phosphate + Hydrogen ion + Pyruvic acid ↔ Carbon dioxide + 1-Deoxy-D-xylulose 5-phosphate
ReactionCard
Thumb+Thumb ↔ Thumb+Thumb
Pyruvic acid + D-Glyceraldehyde 3-phosphate ↔ 1-Deoxy-D-xylulose 5-phosphate + Carbon dioxide
ReactionCard
Complex Reactions:
Thumb+Thumb → Thumb+Thumb
Pyruvic acid + D-Glyceraldehyde 3-phosphate → 1-Deoxy-D-xylulose 5-phosphate + Carbon dioxide
ReactionCard
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB0003011-Deoxy-D-xylulose 5-phosphateMetaboCard
PAMDB000568Carbon dioxideMetaboCard
PAMDB000257D-Glyceraldehyde 3-phosphateMetaboCard
PAMDB001633Hydrogen ionMetaboCard
PAMDB000102Pyruvic acidMetaboCard
GO Classification:
Function
1-deoxy-D-xylulose-5-phosphate synthase activity
catalytic activity
oxidoreductase activity
oxidoreductase activity, acting on the aldehyde or oxo group of donors
oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
transferase activity
transferase activity, transferring aldehyde or ketonic groups
Process
cellular lipid metabolic process
isoprenoid metabolic process
lipid metabolic process
metabolic process
primary metabolic process
terpenoid biosynthetic process
terpenoid metabolic process
Gene Properties
Locus tag: PA4044
Strand: +
Entrez Gene ID: 879037
Accession: NP_252733.1
GI: 15599239
Sequence start: 4526547
Sequence End: 4528430
Sequence Length: 1883
Gene Sequence: 
>PA4044
ATGCCCAAGACGCTCCATGAGATTCCCCGCGAGCGCCCCGCCACGCCCCTGCTCGACCGCGCCTCTTCGCCGGCCGAACTGCGCCGGCTGGGCGAGGCGGACCTGGAAACCCTGGCCGACGAGCTGCGCCAGTACCTGCTGTATACCGTCGGCCAGACCGGCGGTCATTTCGGCGCCGGCCTCGGCGTGGTCGAGCTGACCATTGCCCTGCACTACGTCTTCGACACTCCGGACGACCGCCTGGTCTGGGACGTCGGCCACCAGGCCTATCCGCACAAGATCCTCACCGAGCGCCGCGAGCTGATGGGCACCCTGCGCCAGAAGAACGGCCTGGCGGCCTTCCCGCGCCGCGCAGAGAGCGAGTACGACACCTTCGGCGTCGGCCACTCCAGCACCTCCATCAGCGCCGCCCTGGGCATGGCCATCGCCGCCCGCCTGCAAGGCAAGGAGCGTAAGTCGGTGGCCGTGATCGGCGACGGTGCGCTGACCGCCGGCATGGCCTTCGAGGCACTCAACCACGCCTCGGAAGTCGACGCCGACATGCTGGTGATCCTCAACGACAACGACATGTCGATCTCGCACAACGTCGGCGGGCTCTCCAACTACCTGGCGAAGATCCTCTCCAGCCGCACCTATAGCAGCATGCGCGAGGGCAGCAAGAAGGTGCTCTCGCGCCTGCCCGGGGCCTGGGAGATCGCCCGGCGCACCGAGGAATACGCCAAGGGCATGCTGGTCCCCGGCACCCTGTTCGAGGAGCTCGGCTGGAATTACATCGGCCCGATCGACGGCCACGACCTGCCGACCCTGGTGGCTACCCTGCGCAACATGCGCGACATGAAGGGCCCGCAGTTCCTCCATGTGGTGACCAAGAAAGGCAAGGGCTTCGCCCCGGCCGAACTGGATCCGATCGGCTACCACGCGATCACCAAGCTGGAAGCTCCCGGCAGTGCGCCGAAGAAGACCGGCGGACCCAAGTATTCCAGCGTCTTCGGCCAGTGGCTGTGCGACATGGCCGCCCAGGACGCGCGCCTGCTCGGCATCACCCCGGCGATGAAGGAAGGTTCCGACCTGGTGGCCTTCAGCGAACGTTATCCGGAACGCTACTTCGACGTCGCCATCGCCGAACAGCATGCCGTGACCCTGGCCGCCGGCATGGCCTGCGAGGGCATGAAGCCGGTGGTAGCGATCTACTCGACCTTCCTCCAGCGCGCCTACGACCAGTTGATCCATGACGTCGCCGTGCAGCACCTCGACGTGCTGTTCGCCATCGACCGCGCCGGCCTGGTCGGCGAGGACGGCCCGACCCACGCCGGTAGCTTCGACATCTCCTACCTGCGCTGCATCCCCGGCATGCTGGTGATGACCCCCAGCGACGAGGACGAGCTGCGCAAGCTGCTCACCACCGGCTACCTGTTCGATGGCCCGGCCGCGGTGCGCTATCCGCGCGGCAGCGGCCCCAACCATCCGATCGATCCGGACCTGCAACCGGTGGAGATCGGCAAGGGCGTGGTCCGTCGGCGCGGCGGCAGGGTCGCACTGCTGGTCTTCGGCGTGCAGTTGGCGGAGGCGATGAAGGTCGCCGAAAGCCTCGACGCCACGGTCGTCGACATGCGTTTCGTCAAACCCCTCGACGAAGCCCTGGTACGCGAATTGGCGGGCAGCCACGAACTGCTGGTGACCATCGAGGAAAACGCCGTGATGGGCGGCGCCGGCTCGGCGGTCGGCGAGTTCCTCGCCAGCGAGGGCCTCGAAGTCCCGCTGCTGCAACTGGGCCTGCCCGACTACTACGTCGAACACGCCAAGCCCAGCGAGATGCTCGCCGAATGCGGCCTGGATGCCGCGGGCATCGAAAAGGCAGTACGCCAGCGTCTCGACCGGCAGTAG
Protein Properties
Protein Residues: 627
Protein Molecular Weight: 68 kDa
Protein Theoretical pI: 5.5
Hydropathicity (GRAVY score): -0.107
Charge at pH 7 (predicted): -14.76
Protein Sequence: 
>PA4044
MPKTLHEIPRERPATPLLDRASSPAELRRLGEADLETLADELRQYLLYTVGQTGGHFGAGLGVVELTIALHYVFDTPDDRLVWDVGHQAYPHKILTERRELMGTLRQKNGLAAFPRRAESEYDTFGVGHSSTSISAALGMAIAARLQGKERKSVAVIGDGALTAGMAFEALNHASEVDADMLVILNDNDMSISHNVGGLSNYLAKILSSRTYSSMREGSKKVLSRLPGAWEIARRTEEYAKGMLVPGTLFEELGWNYIGPIDGHDLPTLVATLRNMRDMKGPQFLHVVTKKGKGFAPAELDPIGYHAITKLEAPGSAPKKTGGPKYSSVFGQWLCDMAAQDARLLGITPAMKEGSDLVAFSERYPERYFDVAIAEQHAVTLAAGMACEGMKPVVAIYSTFLQRAYDQLIHDVAVQHLDVLFAIDRAGLVGEDGPTHAGSFDISYLRCIPGMLVMTPSDEDELRKLLTTGYLFDGPAAVRYPRGSGPNHPIDPDLQPVEIGKGVVRRRGGRVALLVFGVQLAEAMKVAESLDATVVDMRFVKPLDEALVRELAGSHELLVTIEENAVMGGAGSAVGEFLASEGLEVPLLQLGLPDYYVEHAKPSEMLAECGLDAAGIEKAVRQRLDRQ
References
External Links:
Resource Link
Genome ID: PA4044
Entrez Gene ID: 879037
NCBI Protein ID: 15599239
General Reference: PaperBLAST - Find papers about PA4044 and its homologs