Adenylosuccinate lyase (PA2629)

Identification
Name: Adenylosuccinate lyase
Synonyms:
  • ASL
  • Adenylosuccinase
  • ASase
Gene Name: purB
Enzyme Class:
Biological Properties
General Function: Involved in N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity
Specific Function: N(6)-(1,2-dicarboxyethyl)AMP = fumarate + AMP
Cellular Location: Not Available
KEGG Pathways:
KEGG Reactions:
Thumb ↔ Thumb+Thumb
Adenylsuccinic acid ↔ Adenosine monophosphate + Fumaric acid
ReactionCard
Thumb ↔ Thumb+Thumb
SAICAR ↔ Fumaric acid + AICAR
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Thumb+Thumb ↔ Thumb+Thumb+Thumb
Adenylsuccinic acid + SAICAR ↔ Fumaric acid + Adenosine monophosphate + AICAR
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SMPDB Reactions:
N(6)-(1,2-dicarboxyethyl)AMP → Thumb+Thumb
N(6)-(1,2-dicarboxyethyl)AMP → Fumaric acid + Adenosine monophosphate
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SAICAR+Thumb → Thumb+Thumb
SAICAR + SAICAR → AICAR + Fumaric acid
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N(6)-(1,2-dicarboxyethyl)AMP+Thumb → Thumb+Thumb
N(6)-(1,2-dicarboxyethyl)AMP + Adenylsuccinic acid → Fumaric acid + Adenosine monophosphate
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PseudoCyc/BioCyc Reactions:
Thumb → Thumb+Thumb
SAICAR → Fumaric acid + AICAR
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Complex Reactions:
Thumb ↔ Thumb+Thumb
SAICAR ↔ Phosphoribosyl formamidocarboxamide + Fumaric acid
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Thumb → Thumb+Thumb
Adenylsuccinic acid → Fumaric acid + Adenosine monophosphate
ReactionCard
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB000014Adenosine monophosphateMetaboCard
PAMDB000340Adenylsuccinic acidMetaboCard
PAMDB000407AICARMetaboCard
PAMDB000073Fumaric acidMetaboCard
PAMDB000388Phosphoribosyl formamidocarboxamideMetaboCard
PAMDB000186SAICARMetaboCard
GO Classification:
Function
amidine-lyase activity
carbon-nitrogen lyase activity
catalytic activity
lyase activity
N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity
Process
cellular nitrogen compound metabolic process
IMP biosynthetic process
metabolic process
nitrogen compound metabolic process
nucleobase, nucleoside and nucleotide metabolic process
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
nucleoside phosphate metabolic process
nucleotide metabolic process
purine nucleoside monophosphate biosynthetic process
purine nucleotide biosynthetic process
purine nucleotide metabolic process
purine ribonucleoside monophosphate biosynthetic process
purine ribonucleotide biosynthetic process
Gene Properties
Locus tag: PA2629
Strand: +
Entrez Gene ID: 882336
Accession: NP_251319.1
GI: 15597825
Sequence start: 2972699
Sequence End: 2974069
Sequence Length: 1370
Gene Sequence: 
>PA2629
ATGCAGCTTTCCTCGCTCACCGCGGTATCCCCCGTCGATGGCCGCTATGCCGGCAAAACCAGCAGCCTGCGTCCGATCTTCAGCGAATACGGCCTGATCCGTTTCCGCGTCATGGTGGAAGTCCGCTGGCTGCAGCGCCTCGCCGCCCACGCCGGGATTCCCGAGGTCGCGCCGTTCTCCGCCGAAGCCAACGCCCTGCTCGACAGCCTGGCCAGCGACTTCCAGCTGGAACACGCCGAACGCATCAAGGAAATCGAGCGCACCACCAACCACGACGTGAAAGCCGTGGAGTACCTGCTCAAGGAACAGGCCGCCAAGCTTCCGGAGCTGGCCGCGGTCAGCGAGTTCATCCACTTCGCCTGCACCTCCGAGGACATCAACAACCTGTCCCACGCCCTGATGCTCCGCGAGGGTCGCGACAGCGTGCTGCTGCCGCTGATGCGCCAGATCGCCGAGGCCATCCGCGAACTGGCGGTGAAACTCGCCGACGTGCCGATGCTCTCCCGCACCCACGGCCAGCCTGCCTCGCCGACCACCCTGGGCAAGGAACTGGCCAACGTCGTCTACCGCCTGGAGCGGCAGATCAAGCAGGTCGCCGGCATCGAGTTGCTGGGCAAGATCAACGGTGCCGTGGGCAACTACAACGCCCACCTGTCCGCCTATCCCGAAGTCGACTGGGAAGCCAACGCGCGCCAGTTCATCGAAGGCGACCTCGGCCTGACCTTCAACCCCTACACCACTCAGATCGAGCCGCACGACTACATCGCCGAGCTGTTCGATGCGATCGCCCGCTTCAACACCATCCTCATCGACTTCGACCGCGACGTCTGGGGCTACATCTCCCTCGGCTATTTCAAGCAGAAGACCGTGGCCGGCGAGATCGGCTCCTCGACCATGCCGCACAAGGTCAACCCGATCGACTTCGAGAACTCCGAGGGCAACCTCGGCATCGCCAACGCGCTGTTCCAGCACCTGGCCAGCAAGCTGCCGATCTCGCGCTGGCAGCGCGACCTGACCGACTCCACCGTGCTGCGCAACCTCGGCGTCGGCATCGCCCACAGCATCATCGCCTACGAGGCCAGCCTGAAGGGCATCGGCAAGCTGGAGCTGAACGCCCAGCGCATCGCCGAGGACCTGGACGCCTGCTGGGAAGTCCTCGCCGAGCCGGTGCAGACCGTGATGCGTCGCTATGGCGTGGAAAACCCCTACGAGAAGCTGAAGGAACTGACCCGCGGCAAAGGCATCAGCGCCGAAGCCTTGCAGACTTTCATCGAAGAGCTGGCGATTCCCGCCGAGGCCAAGGTCGAGCTGAAGAAGCTGACCCCGGCCGGCTACGTCGGCAATGCCGCCGCCCAGGCCAAGCGCATCTGA
Protein Properties
Protein Residues: 456
Protein Molecular Weight: 50.5 kDa
Protein Theoretical pI: 5.66
Hydropathicity (GRAVY score): -0.116
Charge at pH 7 (predicted): -8.39
Protein Sequence: 
>PA2629
MQLSSLTAVSPVDGRYAGKTSSLRPIFSEYGLIRFRVMVEVRWLQRLAAHAGIPEVAPFSAEANALLDSLASDFQLEHAERIKEIERTTNHDVKAVEYLLKEQAAKLPELAAVSEFIHFACTSEDINNLSHALMLREGRDSVLLPLMRQIAEAIRELAVKLADVPMLSRTHGQPASPTTLGKELANVVYRLERQIKQVAGIELLGKINGAVGNYNAHLSAYPEVDWEANARQFIEGDLGLTFNPYTTQIEPHDYIAELFDAIARFNTILIDFDRDVWGYISLGYFKQKTVAGEIGSSTMPHKVNPIDFENSEGNLGIANALFQHLASKLPISRWQRDLTDSTVLRNLGVGIAHSIIAYEASLKGIGKLELNAQRIAEDLDACWEVLAEPVQTVMRRYGVENPYEKLKELTRGKGISAEALQTFIEELAIPAEAKVELKKLTPAGYVGNAAAQAKRI
References
External Links:
Resource Link
Genome ID: PA2629
Entrez Gene ID: 882336
NCBI Protein ID: 15597825
General Reference: PaperBLAST - Find papers about PA2629 and its homologs