Identification |
Name: |
Methionine synthase |
Synonyms: |
- 5-methyltetrahydrofolate--homocysteine methyltransferase
- Methionine synthase, vitamin-B12-dependent
- MS
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Gene Name: |
metH |
Enzyme Class: |
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Biological Properties |
General Function: |
Involved in methionine synthase activity |
Specific Function: |
Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate |
Cellular Location: |
Not Available |
KEGG Pathways: |
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KEGG Reactions: |
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SMPDB Reactions: |
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5-Methyltetrahydrofolic acid | + | Homocysteine | + | | + | | → | Tetrahydrofolic acid | + | | + | |
| | | | | |
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PseudoCyc/BioCyc Reactions: |
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Complex Reactions: |
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Transports: |
Not Available |
Metabolites: |
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GO Classification: |
Component |
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cell part | intracellular | Function |
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binding | catalytic activity | cation binding | cobalamin binding | homocysteine S-methyltransferase activity | ion binding | metal ion binding | methionine synthase activity | methyltransferase activity | S-methyltransferase activity | transferase activity | transferase activity, transferring one-carbon groups | transition metal ion binding | vitamin binding | zinc ion binding | Process |
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cellular amino acid and derivative metabolic process | cellular amino acid metabolic process | cellular aromatic compound metabolic process | cellular metabolic process | metabolic process | methionine biosynthetic process | pteridine and derivative metabolic process | sulfur amino acid biosynthetic process | sulfur amino acid metabolic process |
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Gene Properties |
Locus tag: |
PA1843 |
Strand: |
- |
Entrez Gene ID: |
880631 |
Accession: |
NP_250534.1 |
GI: |
15597040 |
Sequence start: |
1999889 |
Sequence End: |
2003593 |
Sequence Length: |
3704 |
Gene Sequence: |
>PA1843
ATGTCCAGCCCGCTCACCGATCGCAGCGCCCGCCTGCAAGCCCTCCAGCACGCCCTCAGGGAACGTATCCTGATCCTCGATGGCGGCATGGGCACCATGATCCAGAGCTACAAGCTGGAAGAGGCCGACTACCGCGGCGAGCGCTTCGCCGACTGGCCGAGCGACGTGAAAGGCAACAACGACCTCTTGCTGCTGAGCCGCCCGGACGTGATCCAGGCCATCGAGAAGGCCTACCTCGACGCCGGCGCCGACATCCTCGAGACCAACACCTTCAACGCCACCCAGGTGTCCCAGGCCGACTACGGCATGCAGTCGCTGGCCTACGAACTCAACGTCGAAGGGGCGCGCCTGGCCCGCCAGGTGGCGGACGCGAAGACCGCCGAGACCCCGGACAAGCCGCGTTTCGTCGCCGGCGTGCTCGGCCCGACCAGCCGCACCTGCTCGATTTCCCCGGACGTGAACAACCCCGGCTACCGCAACGTCACCTTCGACGAACTGGTGGAGAACTACGTCGAGGCGACCCGAGGCCTGATCGAAGGCGGCGCCGACCTGATCCTGATCGAGACCATCTTCGACACCCTCAACGCCAAGGCGGCGATCTTCGCCGTCCAGGGCGTGTTCGAGGAACTCGGCGTGGAGCTGCCGATCATGATCTCCGGAACCATCACCGACGCCTCCGGCCGCACCCTGTCGGGCCAGACCACCGAGGCCTTCTGGAACTCGGTGCGGCATGCCCGGCCGATCTCGGTAGGCCTGAACTGCGCCCTCGGCGCCAAGGAATTGCGGCCGTACATCGAGGAACTGTCGACCAAGGCCGACACTCATGTCTCGGCCCACCCCAACGCCGGCCTGCCGAACGCCTTCGGCGAATACGACGAATCGCCGGCGGAAATGGCCGTGGTGGTCGAGGAATTCGCCGCCGCCGGCTTCCTCAATATCGTCGGCGGCTGCTGCGGCACCACCCCGGCGCACATCGAGGCGATCGCCAAGGCAGTGGCCAAGTACCCGCCGCGGGCCATCCCGGAGATTCCCCGGGCCTGTCGCCTGTCCGGCCTGGAGCCGTTCACCATCGACCGCAGCTCGCTGTTCGTCAACGTCGGCGAGCGCACCAACATCACCGGTTCGGCCAAGTTCGCCCGGCTGATCCGCGAGGAAAACTACGCGGAAGCTCTCGAGGTCGCCCAGCAGCAGGTGGAAGCCGGCGCCCAGGTGATCGACATCAACATGGACGAAGGCATGCTGGACTCGAAGGCGGCCATGGTCACCTTCCTCAACCTGATCGCCTCCGAGCCCGACATCTCGCGCGTGCCGATCATGATCGACTCCTCCAAGTGGGAAGTGATCGAGGCCGGCCTGAAGTGCATCCAGGGCAAGGGCATCGTCAACTCGATCTCGATGAAGGAAGGCGTCGAGGCCTTCAAGCACCATGCCCGCCTGTGCAAGCGCTACGGCGCCGCGGTGGTGGTGATGGCCTTCGACGAGGACGGCCAGGCCGACACCCAGGCGCGCAAGGAAGAAATCTGCAAGCGCTCCTACGACATCCTGGTCGACGAAGTCGGCTTCCCACCGGAAGACATCATCTTCGATGCGAACATCTTCGCCATCGCCACCGGCATCGAGGAACACAACAACTACGCGGTCGATTTCATCAACGCCTGCGCCTACATCCGCGACAACCTCCCCTACGCCCTGAGCTCGGGCGGGGTGTCCAACGTGTCCTTCTCGTTCCGCGGCAACAACCCGGTACGCGAGGCGATCCACTCGGTGTTCCTCTACTACGCGATCCGCAACGGCCTGACCATGGGCATCGTCAACGCCGGCCAGCTGGAAATCTACGACGAGATTCCGAAAGCGCTGCGCGACCGGGTCGAGGACGTGGTGCTCAACCGCACGCCCGAGGCCACCGAGGCCCTGCTGGCGATCGCCGACGACTACAAGGGCGGCGGCGCGGTCAAGGAGGCCGAGGACGAGGAATGGCGCAGCTACAGCGTCGAGAAGCGCCTCGAGCATGCGCTGGTCAAGGGCATCACCACCTGGATCGTCGAGGACACCGAGGAATGCCGCCAGCAGTGTGCGCGTCCCATCGAGGTCATCGAAGGTCCGCTGATGTCCGGGATGAACGTGGTCGGCGACCTGTTCGGCGCCGGCAAGATGTTCCTCCCGCAGGTGGTCAAGTCCGCGCGAGTGATGAAGCAGGCGGTGGCCCACCTGATTCCCTTCATCGAGGCGGAGAAAGGCGACAAGCCGGAAGCCAAGGGCAAGATCCTGATGGCCACGGTGAAGGGCGACGTGCACGACATCGGCAAGAACATCGTCGGCGTGGTGCTCGGCTGCAACGGCTATGACGTGGTCGACCTCGGCGTGATGGTGCCGGCGGAGAAGATCCTGCAGACCGCCATCGCCGAGAAATGCGACATCATCGGCCTGTCTGGCCTGATCACGCCGTCGCTGGACGAGATGGTCCACGTCGCCAAGGAAATGCAGCGGCAGAATTTCCAGTTGCCGCTGATGATCGGCGGCGCCACTACCTCGAAGGCGCATACCGCGGTGAAGATCGATCCGCAGTACAGCAACGACGCGGTGGTCTACGTCACCGACGCCTCGCGCGCGGTAGGCGTGGCCACCAGCCTGCTGTCCAAGGAGCTGAAGGCCGACTACGTGGCCCGCACCCGCGCCGACTACGCGGTGGTCCGCGAACGCACGGCCAACCGCAGCGCCCGCACCGAGCGGCTGAGCTACGAACAGGCGATCGCCAACAAGCCGGCGTTCGACTGGGCCGGCTACCAGGCGCCGACGCCTTCCTTCACCGGCGTCAGGGTGCTCGACGAGATCGACCTCGCGGTGCTCGCCGAGTACATCGACTGGACGCCGTTCTTCATTTCCTGGGACCTGGCCGGCAAGTACCCGCGCATCCTCACCGACGAGGTGGTCGGCGAGGCCGCCACCTCGTTGTTCAACGACGCCCAGGCGATGCTGAAGAAGCTGATCGACGAGAAGCTGATCAAGGCCCGCGCGGTGTTCGGCTTCTGGCCGGCCAACCAGGTCGAGCACGACGACCTGGAGGTCTACGGCGCCGATGGCGAGACCCTCGCCACCCTGCACCACCTGCGGCAGCAGACGATCAAGCCGGACGGCAAGCCGAACCTGTCGCTGGCCGATTTCGTCGCGCCGAAGGAAAGCGGCGTGCGCGACTACATCGGCGGCTTCATCACCACCGCCGGGATCGGCGCCGAGGAAGTGGCCAAGGCGTACGAAGCCAAGGGCGACGACTACAACAGCATCATGGTCAAGGCGCTCGCCGACCGCCTCGCCGAAGCCTGCGCCGAGTGGCTGCACGAGCGGGTGCGCAAGGAGTACTGGGGCTACGCCCGCGACGAACACCTCGACAACGAGGCCTTGATCAAGGAGCAATACGTCGGCATCCGCCCGGCACCGGGCTACCCGGCCTGCCCCGACCATACCGAGAAAGGCACTCTGTTCGAACTGCTCGATCCGCAGGGCCTGTCCGGCGTCAGCCTGACCGAGCACTACGCGATGTTCCCGGCCGCGGCGGTCAGCGGTTGGTATTTCGCCCACCCGCAGGCGCAGTACTTCGCGGTCGGCAAGATCGACAAGGACCAGGTGGAACGCTACAGCCAGCGCAAGGGCCAGGAAGCCAGCGTCAGCGAGCGCTGGCTGGCGCCGAACCTTGGCTACGATGACTGA |
Protein Properties |
Protein Residues: |
1234 |
Protein Molecular Weight: |
135.1 kDa |
Protein Theoretical pI: |
4.62 |
Hydropathicity (GRAVY score): |
-0.154 |
Charge at pH 7 (predicted): |
-53.05 |
Protein Sequence: |
>PA1843
MSSPLTDRSARLQALQHALRERILILDGGMGTMIQSYKLEEADYRGERFADWPSDVKGNNDLLLLSRPDVIQAIEKAYLDAGADILETNTFNATQVSQADYGMQSLAYELNVEGARLARQVADAKTAETPDKPRFVAGVLGPTSRTCSISPDVNNPGYRNVTFDELVENYVEATRGLIEGGADLILIETIFDTLNAKAAIFAVQGVFEELGVELPIMISGTITDASGRTLSGQTTEAFWNSVRHARPISVGLNCALGAKELRPYIEELSTKADTHVSAHPNAGLPNAFGEYDESPAEMAVVVEEFAAAGFLNIVGGCCGTTPAHIEAIAKAVAKYPPRAIPEIPRACRLSGLEPFTIDRSSLFVNVGERTNITGSAKFARLIREENYAEALEVAQQQVEAGAQVIDINMDEGMLDSKAAMVTFLNLIASEPDISRVPIMIDSSKWEVIEAGLKCIQGKGIVNSISMKEGVEAFKHHARLCKRYGAAVVVMAFDEDGQADTQARKEEICKRSYDILVDEVGFPPEDIIFDANIFAIATGIEEHNNYAVDFINACAYIRDNLPYALSSGGVSNVSFSFRGNNPVREAIHSVFLYYAIRNGLTMGIVNAGQLEIYDEIPKALRDRVEDVVLNRTPEATEALLAIADDYKGGGAVKEAEDEEWRSYSVEKRLEHALVKGITTWIVEDTEECRQQCARPIEVIEGPLMSGMNVVGDLFGAGKMFLPQVVKSARVMKQAVAHLIPFIEAEKGDKPEAKGKILMATVKGDVHDIGKNIVGVVLGCNGYDVVDLGVMVPAEKILQTAIAEKCDIIGLSGLITPSLDEMVHVAKEMQRQNFQLPLMIGGATTSKAHTAVKIDPQYSNDAVVYVTDASRAVGVATSLLSKELKADYVARTRADYAVVRERTANRSARTERLSYEQAIANKPAFDWAGYQAPTPSFTGVRVLDEIDLAVLAEYIDWTPFFISWDLAGKYPRILTDEVVGEAATSLFNDAQAMLKKLIDEKLIKARAVFGFWPANQVEHDDLEVYGADGETLATLHHLRQQTIKPDGKPNLSLADFVAPKESGVRDYIGGFITTAGIGAEEVAKAYEAKGDDYNSIMVKALADRLAEACAEWLHERVRKEYWGYARDEHLDNEALIKEQYVGIRPAPGYPACPDHTEKGTLFELLDPQGLSGVSLTEHYAMFPAAAVSGWYFAHPQAQYFAVGKIDKDQVERYSQRKGQEASVSERWLAPNLGYDD |
References |
External Links: |
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General Reference: |
PaperBLAST - Find papers about PA1843 and its homologs
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