| Identification |
| Name: |
Threonine dehydratase biosynthetic |
| Synonyms: |
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| Gene Name: |
ilvA |
| Enzyme Class: |
|
| Biological Properties |
| General Function: |
Involved in catalytic activity |
| Specific Function: |
Catalyzes the formation of alpha-ketobutyrate from threonine in a two-step reaction. The first step is a dehydration of threonine, followed by rehydration and liberation of ammonia. Deaminates L-threonine, but also L-serine to a lesser extent |
| Cellular Location: |
Not Available |
| KEGG Pathways: |
- Glycine, serine and threonine metabolism pae00260
- Metabolic pathways pae01100
- Propanoate metabolism pae00640
- Valine, leucine and isoleucine biosynthesis pae00290
|
| KEGG Reactions: |
|
| SMPDB Reactions: |
|
| PseudoCyc/BioCyc Reactions: |
|
| Complex Reactions: |
|
| Transports: |
Not Available |
| Metabolites: |
|
| GO Classification: |
| Function |
|---|
| ammonia-lyase activity | | binding | | carbon-nitrogen lyase activity | | catalytic activity | | cofactor binding | | L-threonine ammonia-lyase activity | | lyase activity | | pyridoxal phosphate binding | | Process |
|---|
| branched chain family amino acid metabolic process | | cellular amino acid and derivative metabolic process | | cellular amino acid metabolic process | | cellular metabolic process | | isoleucine biosynthetic process | | isoleucine metabolic process | | metabolic process |
|
| Gene Properties |
| Locus tag: |
PA1326 |
| Strand: |
+ |
| Entrez Gene ID: |
878607 |
| Accession: |
NP_250017.1 |
| GI: |
15596523 |
| Sequence start: |
1437067 |
| Sequence End: |
1438614 |
| Sequence Length: |
1547 |
| Gene Sequence: |
>PA1326
ATGAGCGCCTCGACCCTCAGCGCAAGCAAACCCCTGCTGGCCGGCTACGTGGAAAGCATCCTGGCCGCGCCGGTGTACGACGTCGCCGTGGAAACCCCCTTGCAGGTCGCGCCGCAGTTGTCCCAGCGCCTGGGCAACCGGGTGCTGCTCAAGCGCGAGGACCTGCAGCCGGTGTTCTCCTTCAAGATCCGCGGCGCCTACACCCGTGTCGCGCGCCTGAGCGACGAGCAGAAGGCCCGCGGGGTGATCACCGCCTCCGCCGGCAACCATGCCCAGGGCCTGGCCCTGGCGGCGCAGCGCCTGGGCGTGCGGGCGGTGATCGTGATGCCGCGCACCACTCCCGAACTCAAGGTCAAGGGCGTGCTGGCACGCGGCGGCGAGGCGTTGCTGCACGGCGACGCCTTCCCCGATGCGCTGGCCCATGCCCTGCAACTGGCCGAGCGCGAAGGCATGACCTTCGTCCCACCCTACGACGATCCGGACGTGATCGCCGGACAGGGCACGGTGGCGATGGAGATCCTCCGCCAGCACAGCGGCCGCCTCGACGCGATCTTCGTGCCGGTCGGCGGCGGCAGCCTGATCGCCGGGATCGCCGCCTACGTCAAGCACCTGCGTCCGGATATTCGCGTGATCGGCGTCGAGCCGGAGGATTCCAACTGCCTGCAGGCGGCGCTGGCCGCCGGCGAACGGGTGGTGCTGGGCCAGGTCGGGCTGTTCGCCGACGGGGTGGCGGTGGCGCAGATCGGCGCTTGCAACTTCGAGGTCTGCAAGGACCATGTCGACGAGGTGATCACCGTCGGCAGCGACGAAATCTGCGCGGCGATCAAGGACATCTACGACGACACCCGTTCGATCACCGAGCCGGCCGGCGCCCTGGCCGTAGCGGGGATCAAGAAGTACGTGGCCCGCGAACGCACCGAGGGGCAGACCCTGGTGGCCATCGACTCCGGTGCCAACATCAACTTCGACCGCCTGCGCCACGTTGCCGAGCGCGCCGAACTGGGCGAACAGCGCGAAGCGATCATCGCCGTCACCGTGGCCGAGCGGCCGGGCAGCTTCAAGGCCTTCTGCGCGGCGCTGGGCCGGCGCCAGATCACCGAGTTCAACTACCGCTACCACAGCGACCGCCAGGCCCACCTGTTCGTCGGCGTGCAGACCCATCCGCTCACCGACAGCCGCGCCGACCTGCTCGCCGGCCTGCGCGAGCAGGGCTTCCCGGTACTCGACCTGACCGACAACGAGATGGCCAAGCTGCACATCCGCCACATGGTCGGCGGCCACGGTACCGAGGTGCGCCGCGAGCGGCTGTTCCGCTTCGAGTTTCCCGAACGCCCCGGGGCCTTGCTGAACTTCCTCGACAAGCTCGGCTCGCGCTGGAACATCAGCCTGTTCCACTACCGCAACCACGGCGCCGCCGACGGTCGGGTGCTGGCCGGATTGCAGGTGCCGGACGAGGAGCGCGGCGAGCTGGAGGCGGCGTTGCAAGCCATCGGCTATCCGTACTGGGAGGAAACCCACAACCCGGCCTACCGGCTGTTCGCCGGTTGA |
| Protein Properties |
| Protein Residues: |
515 |
| Protein Molecular Weight: |
55.9 kDa |
| Protein Theoretical pI: |
6.52 |
| Hydropathicity (GRAVY score): |
-0.07 |
| Charge at pH 7 (predicted): |
-4.28 |
| Protein Sequence: |
>PA1326
MSASTLSASKPLLAGYVESILAAPVYDVAVETPLQVAPQLSQRLGNRVLLKREDLQPVFSFKIRGAYTRVARLSDEQKARGVITASAGNHAQGLALAAQRLGVRAVIVMPRTTPELKVKGVLARGGEALLHGDAFPDALAHALQLAEREGMTFVPPYDDPDVIAGQGTVAMEILRQHSGRLDAIFVPVGGGSLIAGIAAYVKHLRPDIRVIGVEPEDSNCLQAALAAGERVVLGQVGLFADGVAVAQIGACNFEVCKDHVDEVITVGSDEICAAIKDIYDDTRSITEPAGALAVAGIKKYVARERTEGQTLVAIDSGANINFDRLRHVAERAELGEQREAIIAVTVAERPGSFKAFCAALGRRQITEFNYRYHSDRQAHLFVGVQTHPLTDSRADLLAGLREQGFPVLDLTDNEMAKLHIRHMVGGHGTEVRRERLFRFEFPERPGALLNFLDKLGSRWNISLFHYRNHGAADGRVLAGLQVPDEERGELEAALQAIGYPYWEETHNPAYRLFAG |
| References |
| External Links: |
|
| General Reference: |
PaperBLAST - Find papers about PA1326 and its homologs
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