Anthranilate synthase component II (PA0650)

Identification
Name: Anthranilate synthase component II
Synonyms:
  • Glutamine amidotransferase
  • Anthranilate phosphoribosyltransferase
Gene Name: trpD
Enzyme Class:
Biological Properties
General Function: Involved in anthranilate phosphoribosyltransferase activity
Specific Function: Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate
Cellular Location: Not Available
KEGG Pathways:
KEGG Reactions:
Thumb+Thumb ↔ Thumb+Thumb+Thumb+Thumb
Chorismate + L-Glutamine ↔ 2-Aminobenzoic acid + L-Glutamate + Hydrogen ion + Pyruvic acid
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Thumb+Thumb → Thumb+Thumb
2-Aminobenzoic acid + Phosphoribosyl pyrophosphate → Pyrophosphate + N-(5-Phospho-D-ribosyl)anthranilate
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Thumb+Thumb ↔ Thumb+Thumb+Thumb
Chorismate + Ammonia ↔ 2-Aminobenzoic acid + Pyruvic acid + Water
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Thumb+Thumb ↔ Thumb+Thumb+Thumb
Chorismate + L-Glutamine ↔ 2-Aminobenzoic acid + Pyruvic acid + L-Glutamate
ReactionCard
Thumb+Thumb ↔ Thumb+Thumb
N-(5-Phospho-D-ribosyl)anthranilate + Pyrophosphate ↔ 2-Aminobenzoic acid + Phosphoribosyl pyrophosphate
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Thumb+Thumb → Thumb+Thumb+Thumb+Thumb
Chorismate + L-Glutamine → Hydrogen ion + 2-Aminobenzoic acid + Pyruvic acid + L-Glutamate
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SMPDB Reactions:
Thumb+Thumb → L-Glutamic acid+Thumb+Thumb+Thumb+Thumb
Chorismate + L-Glutamine → L-Glutamic acid + Pyruvic acid + Hydrogen ion + 2-Aminobenzoic acid + L-Glutamate
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Thumb+Thumb → Pyrophosphate+ N-(5-phosphoribosyl)-anthranilate+Thumb
2-Aminobenzoic acid + Phosphoribosyl pyrophosphate → Pyrophosphate + N-(5-phosphoribosyl)-anthranilate + N-(5-phosphoribosyl)-anthranilate
ReactionCard
PseudoCyc/BioCyc Reactions:
Thumb+Thumb ↔ Thumb+Thumb+Thumb+Thumb
Chorismate + L-Glutamine ↔ 2-Aminobenzoic acid + L-Glutamate + Hydrogen ion + Pyruvic acid
ReactionCard
Thumb+Thumb → Thumb+Thumb
2-Aminobenzoic acid + Phosphoribosyl pyrophosphate → Pyrophosphate + N-(5-Phospho-D-ribosyl)anthranilate
ReactionCard
Thumb+Thumb → Thumb+Thumb+Thumb+Thumb
Chorismate + L-Glutamine → Hydrogen ion + 2-Aminobenzoic acid + Pyruvic acid + L-Glutamate
ReactionCard
Thumb+Thumb ← Thumb+Thumb
N-(5-Phospho-D-ribosyl)anthranilate + Pyrophosphate ← 2-Aminobenzoic acid + Phosphoribosyl pyrophosphate
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Complex Reactions:
Thumb+Thumb → Thumb+Thumb+Thumb
Chorismate + L-Glutamine → 2-Aminobenzoic acid + Pyruvic acid + L-Glutamate
ReactionCard
Thumb+Thumb → Thumb+Thumb
N-(5-Phospho-D-ribosyl)anthranilate + Pyrophosphate → 2-Aminobenzoic acid + Phosphoribosyl pyrophosphate
ReactionCard
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB006317 N-(5-phosphoribosyl)-anthranilateMetaboCard
PAMDB0002622-Aminobenzoic acidMetaboCard
PAMDB000017AmmoniaMetaboCard
PAMDB000828ChorismateMetaboCard
PAMDB001633Hydrogen ionMetaboCard
PAMDB000055L-GlutamateMetaboCard
PAMDB000163L-GlutamineMetaboCard
PAMDB001021N-(5-Phospho-D-ribosyl)anthranilateMetaboCard
PAMDB000115Phosphoribosyl pyrophosphateMetaboCard
PAMDB000633PyrophosphateMetaboCard
PAMDB000102Pyruvic acidMetaboCard
PAMDB000142WaterMetaboCard
GO Classification:
Function
anthranilate phosphoribosyltransferase activity
anthranilate synthase activity
carbon-carbon lyase activity
catalytic activity
lyase activity
oxo-acid-lyase activity
transferase activity
transferase activity, transferring glycosyl groups
transferase activity, transferring pentosyl groups
Process
biosynthetic process
cellular amino acid and derivative metabolic process
cellular amino acid derivative metabolic process
cellular amino acid metabolic process
cellular biogenic amine metabolic process
cellular metabolic process
glutamine family amino acid metabolic process
glutamine metabolic process
indolalkylamine metabolic process
metabolic process
tryptophan biosynthetic process
tryptophan metabolic process
Gene Properties
Locus tag: PA0650
Strand: +
Entrez Gene ID: 880665
Accession: NP_249341.1
GI: 15595847
Sequence start: 704084
Sequence End: 705133
Sequence Length: 1049
Gene Sequence: 
>PA0650
ATGGATATCAAGGGAGCCCTCAATCGCATCGTCAACCAGCTCGACCTGACCACCGAGGAAATGCAGGCGGTCATGCGCCAGATCATGACCGGGCAGTGCACCGACGCGCAGATCGGCGCCTTCCTGATGGGCATGCGGATGAAGAGCGAAACCATCGACGAGATCGTCGGCGCGGTGGCGGTGATGCGCGAACTGGCCGACGGCGTGCAGTTGCCTACGCTGAAGCATGTGGTCGACGTGGTCGGCACCGGCGGCGATGGCGCGAACATCTTCAACGTGTCCTCGGCGGCGTCCTTCGTGGTCGCCGCCGCTGGCGGCAAGGTCGCCAAACACGGTAACCGCGCGGTCTCCGGCAAGAGCGGCAGCGCCGACTTGCTGGAAGCCGCCGGCATCTACCTGGAGCTGACCTCCGAACAGGTGGCGCGTTGCATCGACACCGTCGGCGTCGGGTTCATGTTCGCCCAGGTCCACCACAAGGCGATGAAGTACGCCGCCGGTCCGCGCCGCGAGCTGGGCTTGCGGACTCTGTTCAACATGCTTGGCCCACTGACCAACCCGGCGGGAGTCAGGCACCAGGTGGTCGGGGTGTTCACCCAGGAACTGTGCAAGCCGCTGGCTGAAGTGCTCAAGCGTCTCGGCAGCGAGCATGTGCTGGTGGTGCATTCGCGCGACGGGCTGGACGAGTTCAGTCTGGCCGCGGCGACCCACATTGCCGAGTTGAAGGACGGCGAGGTACGCGAGTACGAAGTGCGTCCCGAGGACTTCGGGATCAAGAGCCAGACCCTGATGGGGCTGGAGGTCGACAGTCCGCAGGCCTCGCTGGAACTGATCCGCGACGCTTTGGGGCGGCGCAAGACCGAGGCTGGGCAGAAGGCCGCCGAGCTGATCGTGATGAATGCCGGCCCGGCACTGTACGCTGCCGATCTGGCGACCAGCCTGCACGAGGGCATTCAACTGGCCCACGATGCCCTGCACACCGGGCTGGCACGGGAGAAGATGGACGAACTGGTGGCCTTCACCGCCGTTTACAGAGAGGAGAACGCACAGTGA
Protein Properties
Protein Residues: 349
Protein Molecular Weight: 37.4 kDa
Protein Theoretical pI: 5.59
Hydropathicity (GRAVY score): 0.021
Charge at pH 7 (predicted): -8.43
Protein Sequence: 
>PA0650
MDIKGALNRIVNQLDLTTEEMQAVMRQIMTGQCTDAQIGAFLMGMRMKSETIDEIVGAVAVMRELADGVQLPTLKHVVDVVGTGGDGANIFNVSSAASFVVAAAGGKVAKHGNRAVSGKSGSADLLEAAGIYLELTSEQVARCIDTVGVGFMFAQVHHKAMKYAAGPRRELGLRTLFNMLGPLTNPAGVRHQVVGVFTQELCKPLAEVLKRLGSEHVLVVHSRDGLDEFSLAAATHIAELKDGEVREYEVRPEDFGIKSQTLMGLEVDSPQASLELIRDALGRRKTEAGQKAAELIVMNAGPALYAADLATSLHEGIQLAHDALHTGLAREKMDELVAFTAVYREENAQ
References
External Links:
Resource Link
Genome ID: PA0650
Entrez Gene ID: 880665
NCBI Protein ID: 15595847
General Reference: PaperBLAST - Find papers about PA0650 and its homologs