4-hydroxythreonine-4-phosphate dehydrogenase (PA0593)

Identification
Name: 4-hydroxythreonine-4-phosphate dehydrogenase
Synonyms:
  • 4-(phosphohydroxy)-L-threonine dehydrogenase
Gene Name: pdxA
Enzyme Class:
Biological Properties
General Function: Involved in 4-hydroxythreonine-4-phosphate dehydrogenase activity
Specific Function: Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
Cellular Location: Cytoplasm
KEGG Pathways:
KEGG Reactions:
Thumb+Thumb ↔ Thumb+Thumb+Thumb
O-Phospho-4-hydroxy-L-threonine + NAD ↔ 2-Amino-3-oxo-4-phosphonooxybutyrate + NADH + Hydrogen ion
ReactionCard
Thumb+Thumb+Thumb ↔ Thumb+Thumb+Thumb+Thumb
NAD + 2-Amino-3-oxo-4-phosphonooxybutyrate + O-Phospho-4-hydroxy-L-threonine ↔ 3-Amino-2-oxopropyl phosphate + Carbon dioxide + NADH + Hydrogen ion
ReactionCard
SMPDB Reactions:
Thumb+Thumb → Thumb+Thumb+Thumb
O-Phospho-4-hydroxy-L-threonine + NAD → NADH + Hydrogen ion + 2-Amino-3-oxo-4-phosphonooxybutyrate
ReactionCard
PseudoCyc/BioCyc Reactions:
Thumb+Thumb ↔ Thumb+Thumb+Thumb
O-Phospho-4-hydroxy-L-threonine + NAD ↔ 2-Amino-3-oxo-4-phosphonooxybutyrate + NADH + Hydrogen ion
ReactionCard
Complex Reactions:
Thumb+Thumb+Thumb → Thumb+Thumb+2 Thumb+Thumb+Thumb+Thumb
1-Deoxy-D-xylulose 5-phosphate + NAD + O-Phospho-4-hydroxy-L-threonine → Carbon dioxide + Hydrogen ion + 2 Water + NADH + Pyridoxine 5'-phosphate + Phosphate
ReactionCard
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB0005591-Amino-propan-2-one-3-phosphateMetaboCard
PAMDB0003011-Deoxy-D-xylulose 5-phosphateMetaboCard
PAMDB0008852-Amino-3-oxo-4-phosphonooxybutyrateMetaboCard
PAMDB0042503-Amino-2-oxopropyl phosphateMetaboCard
PAMDB000568Carbon dioxideMetaboCard
PAMDB001633Hydrogen ionMetaboCard
PAMDB000197NADMetaboCard
PAMDB000398NADHMetaboCard
PAMDB000691O-Phospho-4-hydroxy-L-threonineMetaboCard
PAMDB000383PhosphateMetaboCard
PAMDB000338Pyridoxine 5'-phosphateMetaboCard
PAMDB000142WaterMetaboCard
GO Classification:
Function
4-hydroxythreonine-4-phosphate dehydrogenase activity
binding
catalytic activity
NAD or NADH binding
nucleotide binding
oxidoreductase activity
oxidoreductase activity, acting on CH-OH group of donors
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Process
metabolic process
oxidation reduction
pyridoxine biosynthetic process
pyridoxine metabolic process
small molecule metabolic process
vitamin B6 metabolic process
vitamin metabolic process
water-soluble vitamin metabolic process
Gene Properties
Locus tag: PA0593
Strand: -
Entrez Gene ID: 880733
Accession: NP_249284.1
GI: 15595790
Sequence start: 651497
Sequence End: 652483
Sequence Length: 986
Gene Sequence: 
>PA0593
GTGAGCCTGCGCTTCGCGCTCACTCCCGGCGAGCCGGCAGGTATCGGACCCGATCTGTGCCTGCTGCTCGCCCGCTCCGCCCAGCCCCACCCCCTGATCGCCATCGCCAGCCGCACGCTCCTGCAAGAGCGCGCCGGCCAACTGGGCCTGGCGATCGACCTTAAGGACGTTTCCCCGGCCGCCTGGCCAGAGCGACCGGCCAAGGCCGGCCAACTGTACGTATGGGATACGCCCCTGGCCGCCCCGGTCCGGCCCGGGCAATTGGACCGAGCCAACGCCGCCTACGTCCTGGAAACCCTGACCCGCGCCGGCCAGGGCTGCCTCGACGGGCACTTCGCCGGGATGATCACCGCACCGGTGCACAAGGGCGTGATCAACGAAGCCGGCATCCCCTTTTCCGGCCATACCGAATTCCTCGCCGACCTCACCCACACCGCCCAGGTGGTGATGATGCTGGCCACCCGCGGCCTGCGCGTGGCCCTGGCGACCACCCACCTGCCGCTGCGCGAGGTCGCCGACGCCATTAGCGATGAGCGCCTGACCCGGGTCGCGCGCATCCTCCACGCCGACCTGCGCGACAAGTTCGGCATCGCCCATCCGCGCATCCTGGTCTGCGGACTCAACCCGCACGCCGGCGAAGGCGGTCACCTGGGCCGGGAAGAGATCGAGGTGATCGAACCCTGCCTCGAGCGCCTGCGTGGCGAAGGCCTCGACCTGATCGGCCCGCTGCCGGCCGACACCCTGTTCACTCCCAAGCACCTGGAGCATTGCGACGCGGTGCTGGCGATGTACCACGACCAGGGTCTCCCCGTGCTCAAGTACAAGGGCTTCGGTGCCGCCGTGAACGTGACCCTCGGCCTGCCGATCATCCGCACCTCTGTCGACCACGGTACCGCGCTCGACCTGGCCGGCAGCGGCCGCATCGATAGCGGCAGCCTGCAGGTCGCCCTGGAAACCGCCTACCAGATGGCGGCCAGCCGCTGCTGA
Protein Properties
Protein Residues: 328
Protein Molecular Weight: 34.9 kDa
Protein Theoretical pI: 6.62
Hydropathicity (GRAVY score): 0.121
Charge at pH 7 (predicted): -2.81
Protein Sequence: 
>PA0593
MSLRFALTPGEPAGIGPDLCLLLARSAQPHPLIAIASRTLLQERAGQLGLAIDLKDVSPAAWPERPAKAGQLYVWDTPLAAPVRPGQLDRANAAYVLETLTRAGQGCLDGHFAGMITAPVHKGVINEAGIPFSGHTEFLADLTHTAQVVMMLATRGLRVALATTHLPLREVADAISDERLTRVARILHADLRDKFGIAHPRILVCGLNPHAGEGGHLGREEIEVIEPCLERLRGEGLDLIGPLPADTLFTPKHLEHCDAVLAMYHDQGLPVLKYKGFGAAVNVTLGLPIIRTSVDHGTALDLAGSGRIDSGSLQVALETAYQMAASRC
References
External Links:
Resource Link
Genome ID: PA0593
Entrez Gene ID: 880733
NCBI Protein ID: 15595790
General Reference: PaperBLAST - Find papers about PA0593 and its homologs