Succinate-semialdehyde dehydrogenase [NADP+] (PA0265)

Identification
Name: Succinate-semialdehyde dehydrogenase [NADP+]
Synonyms:
  • SSDH
Gene Name: gabD
Enzyme Class:
Biological Properties
General Function: Involved in oxidoreductase activity
Specific Function: Succinate semialdehyde + NAD(P)(+) + H(2)O = succinate + NAD(P)H
Cellular Location: Not Available
KEGG Pathways:
KEGG Reactions:
Thumb+Thumb+Thumb → 2 Thumb+Thumb+Thumb
Water + NADP + Succinic acid semialdehyde → 2 Hydrogen ion + NADPH + Succinic acid
ReactionCard
Thumb+Thumb+Thumb → 2 Thumb+Thumb+Thumb
Water + NAD + Succinic acid semialdehyde → 2 Hydrogen ion + NADH + Succinic acid
ReactionCard
Thumb+Thumb+Thumb ↔ Thumb+Thumb+Thumb
Succinic acid semialdehyde + NAD + Water ↔ Succinic acid + NADH + Hydrogen ion
ReactionCard
Thumb+Thumb+Thumb ↔ Thumb+Thumb+Thumb
Succinic acid semialdehyde + NADP + Water ↔ Succinic acid + NADPH + Hydrogen ion
ReactionCard
Thumb+Thumb+Thumb+Thumb ↔ Thumb+Thumb+Thumb+2 Thumb
Succinic acid semialdehyde + NAD + NADP + Water ↔ Succinic acid + NADH + NADPH + 2 Hydrogen ion
ReactionCard
SMPDB Reactions:
Thumb+Thumb+Thumb → NADPH+2 Thumb+Thumb+Thumb
Succinic acid semialdehyde + Water + NADP → NADPH + 2 Hydrogen ion + Succinic acid + NADPH
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Thumb+Thumb+Thumb → Thumb+Thumb+2 Thumb
Succinic acid semialdehyde + NAD + Water → Succinic acid + NADH + 2 Hydrogen ion
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PseudoCyc/BioCyc Reactions:
Thumb+Thumb+Thumb → 2 Thumb+Thumb+Thumb
Water + NADP + Succinic acid semialdehyde → 2 Hydrogen ion + NADPH + Succinic acid
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Thumb+Thumb+Thumb → 2 Thumb+Thumb+Thumb
Water + NAD + Succinic acid semialdehyde → 2 Hydrogen ion + NADH + Succinic acid
ReactionCard
Complex Reactions:
Thumb+Thumb+Thumb → Thumb+Thumb
Succinic acid semialdehyde + NADP + Water → Succinic acid + NADPH
ReactionCard
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB001820Glutaric acidMetaboCard
PAMDB001633Hydrogen ionMetaboCard
PAMDB000197NADMetaboCard
PAMDB000398NADHMetaboCard
PAMDB000089NADPMetaboCard
PAMDB000615NADPHMetaboCard
PAMDB000107Succinic acidMetaboCard
PAMDB000313Succinic acid semialdehydeMetaboCard
PAMDB000142WaterMetaboCard
GO Classification:
Function
catalytic activity
oxidoreductase activity
oxidoreductase activity, acting on the aldehyde or oxo group of donors
oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
Process
metabolic process
oxidation reduction
Gene Properties
Locus tag: PA0265
Strand: +
Entrez Gene ID: 881913
Accession: NP_248956.1
GI: 15595462
Sequence start: 299522
Sequence End: 300973
Sequence Length: 1451
Gene Sequence: 
>PA0265
ATGCAACTCAAAGATGCCAAGCTGTTCCGTCAACAAGCCTACGTCGATGGCGCCTGGGTGGATGCCGACAACGGCCAGACCATCAAGGTGAACAACCCGGCCACCGGCGAGATCATCGGCAGCGTGCCGAAGATGGGCGCCGCCGAGACCCGCCGCGCCATCGAGGCTGCCGACAAGGCCCTGCCGGCCTGGCGTGCGCTGACCGCCAAGGAGCGCGCCAACAAGCTGCGCCGCTGGTTCGACCTGATGATCGAGAACCAGGACGACCTGGCCCGCCTGATGACCATCGAGCAGGGCAAGCCGCTGGCCGAGGCCAAGGGCGAGATCGCCTACGCCGCCTCCTTCCTCGAATGGTTCGGCGAAGAAGCCAAGCGCATCTACGGCGACACCATTCCCGGCCACCAGCCGGACAAGCGCATCATCGTGATCAAGCAGCCGATCGGCGTGACCGCGGCCATCACGCCGTGGAACTTCCCCTCGGCGATGATCACCCGCAAGGCCGGCCCGGCCCTGGCCGCCGGCTGCACCATGGTGCTCAAGCCTGCTTCGCAGACCCCGTATTCCGCCCTGGCCCTGGCCGAACTGGCAGAGCGCGCCGGCATTCCGAAGGGCGTGTTCAGCGTGGTCACCGGTAGCGCCGGCGAAGTCGGCGGCGAGCTGACCAGCAACCCGATCGTGCGCAAGCTGACCTTCACCGGTTCCACCGAAATCGGCCGCCAACTGATGGCCGAGTGCGCCCAGGACATCAAGAAGGTGTCCCTGGAGCTGGGCGGCAACGCGCCGTTCATCGTGTTCGACGACGCCGACCTGGACGCCGCCGTCGAGGGCGCGCTGATTTCCAAGTACCGCAATAACGGCCAGACCTGCGTCTGCGCCAACCGCCTGTACGTGCAGGACGGCGTGTACGACGCCTTCGTCGACAAGCTGAAGGCCGCCGTGGCCAAGCTGAACATCGGCAACGGCCTGGAAGCCGGCGTGACCACCGGTCCGCTGATCGACGCCAAGGCCGTGGCCAAGGTCGAGGAACACATCGCCGACGCGGTCTCCAAGGGCGCCAAGGTGGTTTCCGGCGGCAAGCCGCACGCCCTCGGCGGCACCTTCTTCGAGCCGACCATCCTGGTCGACGTGCCGAAGAACGCCCTGGTGTCCAAGGACGAGACCTTCGGCCCGCTGGCGCCGGTGTTCCGCTTCAAGGACGAGGCCGAGGTCATCGCCATGTCCAACGACACCGAGTTCGGCCTGGCGTCCTACTTCTACGCCCGCGACCTGGCCCGCGTGTTCCGCGTCGCCGAGCAACTGGAGTACGGCATGGTCGGCATCAACACCGGCCTGATCTCCAACGAAGTGGCGCCGTTCGGCGGCATCAAGGCCTCGGGCCTGGGCCGCGAAGGTTCCAAGTACGGGATCGAGGACTACCTCGAGATCAAGTACCTCTGCCTGGGCGGTATCTGA
Protein Properties
Protein Residues: 483
Protein Molecular Weight: 51.6 kDa
Protein Theoretical pI: 5.43
Hydropathicity (GRAVY score): -0.031
Charge at pH 7 (predicted): -4.41
Protein Sequence: 
>PA0265
MQLKDAKLFRQQAYVDGAWVDADNGQTIKVNNPATGEIIGSVPKMGAAETRRAIEAADKALPAWRALTAKERANKLRRWFDLMIENQDDLARLMTIEQGKPLAEAKGEIAYAASFLEWFGEEAKRIYGDTIPGHQPDKRIIVIKQPIGVTAAITPWNFPSAMITRKAGPALAAGCTMVLKPASQTPYSALALAELAERAGIPKGVFSVVTGSAGEVGGELTSNPIVRKLTFTGSTEIGRQLMAECAQDIKKVSLELGGNAPFIVFDDADLDAAVEGALISKYRNNGQTCVCANRLYVQDGVYDAFVDKLKAAVAKLNIGNGLEAGVTTGPLIDAKAVAKVEEHIADAVSKGAKVVSGGKPHALGGTFFEPTILVDVPKNALVSKDETFGPLAPVFRFKDEAEVIAMSNDTEFGLASYFYARDLARVFRVAEQLEYGMVGINTGLISNEVAPFGGIKASGLGREGSKYGIEDYLEIKYLCLGGI
References
External Links:
Resource Link
Genome ID: PA0265
Entrez Gene ID: 881913
NCBI Protein ID: 15595462
General Reference: PaperBLAST - Find papers about PA0265 and its homologs