Succinic acid (PAMDB000107)

General function:

Involved in electron carrier activity

Specific function:

Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth

Gene Name:

sdhB

Locus Tag:

PA1584

Molecular weight:

26.2 kDa

Reactions

General function:

Involved in catalytic activity

Specific function:

(S)-dihydroorotate + a quinone = orotate + a quinol

Gene Name:

pyrD

Locus Tag:

PA3050

Molecular weight:

36.1 kDa

Reactions

General function:

Involved in ATP binding

Specific function:

ATP + succinate + CoA = ADP + phosphate + succinyl-CoA

Gene Name:

sucC

Locus Tag:

PA1588

Molecular weight:

41.5 kDa

Reactions

General function:

Involved in isocitrate lyase activity

Specific function:

Catalyzes the formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle. May be involved in the assimilation of one-carbon compounds via the isocitrate lyase- positive serine pathway

Gene Name:

aceA

Locus Tag:

PA2634

Molecular weight:

58.9 kDa

Reactions

General function:

Involved in electron carrier activity

Specific function:

Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth

Gene Name:

sdhA

Locus Tag:

PA1583

Molecular weight:

63.5 kDa

Reactions

General function:

Involved in succinate dehydrogenase activity

Specific function:

Membrane-anchoring subunit of succinate dehydrogenase (SDH)

Gene Name:

sdhD

Locus Tag:

PA1582

Molecular weight:

13.7 kDa

General function:

Involved in metallopeptidase activity

Specific function:

Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls

Gene Name:

dapE

Locus Tag:

PA1162

Molecular weight:

41.1 kDa

Reactions

General function:

Involved in catalytic activity

Specific function:

ATP + succinate + CoA = ADP + phosphate + succinyl-CoA

Gene Name:

sucD

Locus Tag:

PA1589

Molecular weight:

30.3 kDa

Reactions

General function:

Involved in electron carrier activity

Specific function:

Catalyzes the oxidation of L-aspartate to iminoaspartate

Gene Name:

nadB

Locus Tag:

PA0761

Molecular weight:

60 kDa

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Succinate semialdehyde + NAD(P)(+) + H(2)O = succinate + NAD(P)H

Gene Name:

gabD

Locus Tag:

PA0265

Molecular weight:

51.6 kDa

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Catalyzes the conversion of taurine and alpha ketoglutarate to sulfite, aminoacetaldehyde and succinate. Required for the utilization of taurine (2-aminoethanesulfonic acid) as an alternative sulfur source. Pentane-sulfonic acid, 3- (N-morpholino)propanesulfonic acid and 1,3-dioxo-2- isoindolineethanesulfonic acid are also substrates for this enzyme

Gene Name:

tauD

Locus Tag:

PA3935

Molecular weight:

31 kDa

Reactions

General function:

Involved in succinate dehydrogenase activity

Specific function:

Membrane-anchoring subunit of succinate dehydrogenase (SDH)

Gene Name:

sdhC

Locus Tag:

PA1581

Molecular weight:

13.7 kDa

General function:

Involved in catalytic activity

Specific function:

Catalyzes the formation of pyruvate and succinate from 2-methylisocitrate

Gene Name:

prpB

Locus Tag:

PA0796

Molecular weight:

32.1 kDa

Reactions