| Identification |
| Name: |
Isocitrate lyase |
| Synonyms: |
- ICL
- Isocitrase
- Isocitratase
|
| Gene Name: |
aceA |
| Enzyme Class: |
|
| Biological Properties |
| General Function: |
Involved in isocitrate lyase activity |
| Specific Function: |
Catalyzes the formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle. May be involved in the assimilation of one-carbon compounds via the isocitrate lyase- positive serine pathway |
| Cellular Location: |
Cytoplasm |
| KEGG Pathways: |
- Glyoxylate and dicarboxylate metabolism pae00630
- Metabolic pathways pae01100
- Microbial metabolism in diverse environments pae01120
|
| KEGG Reactions: |
|
| SMPDB Reactions: |
|
| PseudoCyc/BioCyc Reactions: |
|
| Complex Reactions: |
|
| Transports: |
Not Available |
| Metabolites: |
|
| GO Classification: |
| Function |
|---|
| carbon-carbon lyase activity | | catalytic activity | | isocitrate lyase activity | | lyase activity | | oxo-acid-lyase activity | | Process |
|---|
| carboxylic acid metabolic process | | cellular metabolic process | | metabolic process | | organic acid metabolic process | | oxoacid metabolic process |
|
| Gene Properties |
| Locus tag: |
PA2634 |
| Strand: |
+ |
| Entrez Gene ID: |
882341 |
| Accession: |
NP_251324.1 |
| GI: |
15597830 |
| Sequence start: |
2977756 |
| Sequence End: |
2979351 |
| Sequence Length: |
1595 |
| Gene Sequence: |
>PA2634
ATGTCCGCATATCAGAACGAGATCAAGGCAGTTGCCGCGCTGAAAGAGAAGAACGGCAGCAGCTGGAGCGCGATCAACCCCGAGTACGCAGCTCGCATGCGTATCCAGAACCGCTTCAAGACCGGCCTGGATATCGCCAAGTACACCGCGGCCATCATGCGCAAGGACATGGCCGAATACGATGCGGACTCCTCCGTCTACACCCAGTCGCTGGGTTGCTGGCACGGCTTCATCGGGCAGCAGAAGCTGATCTCGATCAAGAAGCACCTGAAGACCACCAACAAGCGCTACCTCTACCTGTCCGGTTGGATGGTCGCCGCGCTGCGCTCCGACTTCGGCCCGCTGCCGGACCAGTCCATGCACGAGAAAACCGCGGTTTCCGGCCTGATCGAAGAGCTGTACACCTTCCTGCGCCAGGCTGACGCCCGCGAGCTGGACCTGCTGTTCACCGGCCTGGACGCTGCCCGCGCCGCTGGCGACAAGGCCAAGGAAGCCGAGCTGCTGGCCCAGATCGACAACTTCGAAACCCACGTGGTGCCGATCATCGCCGACATCGACGCCGGCTTCGGCAACGCCGAGGCGACCTACCTGCTGGCCAAGAAGATGATCGAAGCCGGCGCCTGCTGCATCCAGATCGAGAACCAGGTGTCCGACGAGAAGCAGTGCGGCCACCAGGACGGCAAGGTCACCGTTCCGCACATCGACTTCCTCGCCAAGATCAATGCCGTACGCTACGCCTTCCTCGAGCTGGGCGTGGACGATGGCGTGATCGTCGCCCGTACCGACTCCCTGGGCGCCGGCCTGACCAAGCAGATCGCCGTGACCAACGAGCCGGGCGACCTGGGCGACCTGTACAACTCCTTCCTGGATTGCGAAGAAATCTCCGAGTCCGAGCTGGGCAACGGCGACGTCGTGATCAAGCGCGAAGGCAAGCTGCTGCGTCCGAAGCGCCTGGCTTCCAACCTGTTCCAGTTCCGCAAGGGCACCGGCGAAGATCGCTGCGTCCTGGACTGCATCACCTCGCTGCAGAACGGCGCCGACCTGCTCTGGATCGAAACCGAGAAGCCGCACGTCGGCCAGATCAAGGCAATGGTCGATCGCATCCGCGAAGTGATTCCGAACGCCAAGCTGGTCTACAACAACAGCCCGTCCTTCAACTGGACCCTGAACTTCCGCCAGCAGGTGTTCGATGCGTTCGTCGCCGAAGGCAAGGACGTTTCCGCCTACGACCGCAACAAGCTGATGAGCGTCGAGTACGACGACACCGAGCTGGCCAAGGTCGCCGACGAGAAGATCCGCACCTTCCAGCGCGATGGCTCGGCCCACGCCGGCATCTTCCACCACCTGATCACCCTGCCGACCTACCACACCGCCGCGCTGTCCACCGACAACCTGGCCAAGGGCTACTTCGCCGACGAAGGCATGCTGGCCTACGTGAAGGGCGTGCAGCGCCAGGAACTGCGCCAGGGCATCGCCTGCGTCAAGCACCAGAACATGGCGGGCTCCGACATCGGCGACAACCATAAAGAGTACTTCGCAGGCGAAGCCGCTCTGAAGGCCAGCGGCAAAGACAACACCATGAACCAGTTCCACTAA |
| Protein Properties |
| Protein Residues: |
531 |
| Protein Molecular Weight: |
58.9 kDa |
| Protein Theoretical pI: |
5.91 |
| Hydropathicity (GRAVY score): |
-0.317 |
| Charge at pH 7 (predicted): |
-8.85 |
| Protein Sequence: |
>PA2634
MSAYQNEIKAVAALKEKNGSSWSAINPEYAARMRIQNRFKTGLDIAKYTAAIMRKDMAEYDADSSVYTQSLGCWHGFIGQQKLISIKKHLKTTNKRYLYLSGWMVAALRSDFGPLPDQSMHEKTAVSGLIEELYTFLRQADARELDLLFTGLDAARAAGDKAKEAELLAQIDNFETHVVPIIADIDAGFGNAEATYLLAKKMIEAGACCIQIENQVSDEKQCGHQDGKVTVPHIDFLAKINAVRYAFLELGVDDGVIVARTDSLGAGLTKQIAVTNEPGDLGDLYNSFLDCEEISESELGNGDVVIKREGKLLRPKRLASNLFQFRKGTGEDRCVLDCITSLQNGADLLWIETEKPHVGQIKAMVDRIREVIPNAKLVYNNSPSFNWTLNFRQQVFDAFVAEGKDVSAYDRNKLMSVEYDDTELAKVADEKIRTFQRDGSAHAGIFHHLITLPTYHTAALSTDNLAKGYFADEGMLAYVKGVQRQELRQGIACVKHQNMAGSDIGDNHKEYFAGEAALKASGKDNTMNQFH |
| References |
| External Links: |
|
| General Reference: |
PaperBLAST - Find papers about PA2634 and its homologs
|
