Reaction 21790

Reaction Details
Reaction: Thumb
3-methyl-2-oxobutanoate + acetyl-CoA + H2O → (2S)-2-isopropylmalate + coenzyme A + H+
Enzymes:
External Links:
ResourceLink
PseudoCyc Reaction ID:2-ISOPROPYLMALATESYN-RXN
References:
  • Cole FE, Kalyanpur MG, Stevens CM (1973). "Absolute configuration of alpha isopropylmalate and the mechanism of its conversion to beta isopropylmalate in the biosynthesis of leucine." Biochemistry 12(17);3346-50. PMID: 4270046
  • Kohlhaw G, Leary TR, Umbarger HE (1969). "Alpha-isopropylmalate synthase from Salmonella typhimurium. Purification and properties." J Biol Chem 1969;244(8);2218-25. PMID: 4976555