Identification
Name: Phosphoribosylaminoimidazole carboxylase ATPase subunit
Synonyms:
  • AIR carboxylase
  • AIRC
Gene Name: purK
Enzyme Class:
Biological Properties
General Function: Involved in phosphoribosylaminoimidazole carboxylase activity
Specific Function: Possesses an ATPase activity that is dependent on the presence of AIR (aminoimidazole ribonucleotide). The association of purK and purE produces an enzyme complex capable of converting AIR to CAIR efficiently under physiological condition
Cellular Location: Not Available
KEGG Pathways:
KEGG Reactions:
Thumb+Thumb+ThumbThumb+Thumb+5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole+Thumb
ThumbThumb+Thumb
SMPDB Reactions:
Thumb+Thumb+ThumbN5-Carboxyaminoimidazole ribonucleotide+Adenosine diphosphate+Thumb+2 Thumb+Thumb+Thumb
Thumb+Thumb+ThumbThumb+Thumb+Thumb+Thumb
PseudoCyc/BioCyc Reactions:
Thumb+Thumb+ThumbThumb+Thumb+Thumb+Thumb
Thumb+Thumb+ThumbThumb+Thumb+5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole+Thumb
Thumb+Thumb+ThumbThumb+Thumb+Thumb
ThumbThumb+Thumb
Thumb+Thumb+ThumbN5-Carboxyaminoimidazole ribonucleotide+Adenosine diphosphate+Thumb+2 Thumb+Thumb+Thumb
Thumb
5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + 2 H+ = 5-amino-1-(5-phospho-β-D-ribosyl)imidazole + CO2
ReactionCard
Complex Reactions:
Thumb+Thumb+ThumbThumb+Thumb+Thumb+Thumb
Thumb+Thumb+ThumbThumb+Thumb+Thumb
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB0003065-Aminoimidazole ribonucleotideMetaboCard
PAMDB0034105-carboxyamino-1-(5-phospho-D-ribosyl)imidazoleMetaboCard
PAMDB0015875-Phosphoribosyl-5-carboxyaminoimidazoleMetaboCard
PAMDB000148Adenosine triphosphateMetaboCard
PAMDB000345ADPMetaboCard
PAMDB000510Carbonic acidMetaboCard
PAMDB000153Hydrogen carbonateMetaboCard
PAMDB001633Hydrogen ionMetaboCard
PAMDB001776Inorganic phosphateMetaboCard
PAMDB000337N5-Carboxyaminoimidazole ribonucleotideMetaboCard
PAMDB000383PhosphateMetaboCard
GO Classification:
Function
adenyl nucleotide binding
adenyl ribonucleotide binding
ATP binding
binding
carbon-carbon lyase activity
carboxy-lyase activity
catalytic activity
lyase activity
nucleoside binding
phosphoribosylaminoimidazole carboxylase activity
purine nucleoside binding
Process
'de novo' IMP biosynthetic process
cellular nitrogen compound metabolic process
IMP biosynthetic process
metabolic process
nitrogen compound metabolic process
nucleobase, nucleoside and nucleotide metabolic process
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
nucleoside phosphate metabolic process
nucleotide metabolic process
purine nucleoside monophosphate biosynthetic process
purine nucleotide biosynthetic process
purine nucleotide metabolic process
purine ribonucleoside monophosphate biosynthetic process
Gene Properties
Locus tag: PA5425
Strand: -
Entrez Gene ID: 878440
Accession: NP_254112.1
GI: 15600618
Sequence start: 6105159
Sequence End: 6106241
Sequence Length: 1082
Gene Sequence:
>PA5425
ATGAAAATCGGTGTCATCGGTGGCGGCCAGCTGGGCCGCATGCTGGCCCTGGCGGGAACCCCGCTGGGCATGAACTTCGCTTTCCTCGACCCGGCGCCGGACGCCTGCGCGGCCTCCCTGGGCGAGCACATCCGCGCCGACTACGGCGACCAGGAGCACCTGCGGCAACTGGCCGACGAGGTCGACCTGGTAACCTTCGAGTTCGAGAGCGTGCCGGCGGAAACCGTGGCCTTCCTCTCCCAGTTCGTGCCGGTCTACCCGAACGCCGAGTCGCTGCGCATCGCCCGCGACCGCTGGTTCGAGAAGTCGATGTTCAAGGACCTTGGCATTCCCACTCCGGACTTCGCCGACGTCCAGTCCCAGGCCGACCTCGATGCCGCCGCAGCCGCCATCGGCCTGCCGGCGGTGCTCAAGACCCGCACCCTGGGCTACGACGGCAAGGGCCAGAAGGTCCTGCGCCAGCCGGCCGACGTGCAGGGCGCGTTCGCCGAACTGGGCAGCGTGCCGTGCATCCTCGAGGGCTTCGTGCCGTTCACCGGGGAAGTCTCGCTGGTGGCGGTGCGCGCTCGCGATGGCGAGACGCGTTTCTACCCGCTGGTGCACAACACCCACGACAGCGGCATCCTCAAGCTCTCCGTGGCCAGCAGCGGGCATCCGTTGCAGGCGCTGGCCGAGGACTACGTCGGCCGCGTGCTGGCCCGGCTCGACTACGTCGGCGTGCTGGCCTTCGAGTTCTTCGAGGTGGACGGCGGCCTGAAGGCCAACGAGATCGCCCCGCGCGTGCACAACTCCGGGCACTGGACCATCGAAGGCGCCGAGTGCAGCCAGTTCGAGAACCACTTGCGCGCCGTCGCCGGCCTGCCGCTGGGCTCGACCGCCAAGGTCGGCGAGAGCGCGATGCTCAATTTCATCGGCGCGGTCCCCCCGGTGGCTCAGGTGGTCGCCGTCGCCGACTGCCACCTGCATCACTACGGCAAGGCCTTCAAGAACGGCCGCAAGGTCGGCCACGCCACCCTGCGTTGTGCCGACCGGGCGACGCTGCAGGCGCGCATCGCCGAGGTCGAGGCGCTGATCGAGGCGTGA
Protein Properties
Protein Residues: 360
Protein Molecular Weight: 38.5 kDa
Protein Theoretical pI: 5.38
Hydropathicity (GRAVY score): 0.082
Charge at pH 7 (predicted): -10.26
Protein Sequence:
>PA5425
MKIGVIGGGQLGRMLALAGTPLGMNFAFLDPAPDACAASLGEHIRADYGDQEHLRQLADEVDLVTFEFESVPAETVAFLSQFVPVYPNAESLRIARDRWFEKSMFKDLGIPTPDFADVQSQADLDAAAAAIGLPAVLKTRTLGYDGKGQKVLRQPADVQGAFAELGSVPCILEGFVPFTGEVSLVAVRARDGETRFYPLVHNTHDSGILKLSVASSGHPLQALAEDYVGRVLARLDYVGVLAFEFFEVDGGLKANEIAPRVHNSGHWTIEGAECSQFENHLRAVAGLPLGSTAKVGESAMLNFIGAVPPVAQVVAVADCHLHHYGKAFKNGRKVGHATLRCADRATLQARIAEVEALIEA
References
External Links:
Resource Link
Genome ID: PA5425
Entrez Gene ID: 878440
NCBI Protein ID: 15600618
General Reference: PaperBLAST - Find papers about PA5425 and its homologs