Choline dehydrogenase (PA5372)

Identification
Name: Choline dehydrogenase
Synonyms:
  • CDH
  • CHD
Gene Name: betA
Enzyme Class:
Biological Properties
General Function: Involved in choline dehydrogenase activity
Specific Function: Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
Cellular Location: Cell membrane; Peripheral membrane protein
KEGG Pathways:
KEGG Reactions:
Thumb+Acceptor+Acceptor ↔ Thumb+Reduced acceptor+Reduced acceptor
Choline + Acceptor + Acceptor ↔ Betaine aldehyde + Reduced acceptor + Reduced acceptor
ReactionCard
SMPDB Reactions: Not Available
PseudoCyc/BioCyc Reactions:
Thumb+an oxidized electron acceptor → Thumb+a reduced electron acceptor
Choline + an oxidized electron acceptor → Betaine aldehyde + a reduced electron acceptor
ReactionCard
Complex Reactions:
Thumb+Thumb → Thumb+Thumb+Thumb
Choline + NAD → Betaine aldehyde + Hydrogen ion + NADH
ReactionCard
Thumb+acceptor → Thumb+reduced acceptor
Choline + acceptor → Betaine aldehyde + reduced acceptor
ReactionCard
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB000309Betaine aldehydeMetaboCard
PAMDB000036CholineMetaboCard
PAMDB001633Hydrogen ionMetaboCard
PAMDB000197NADMetaboCard
PAMDB000398NADHMetaboCard
GO Classification:
Function
adenyl nucleotide binding
binding
catalytic activity
choline dehydrogenase activity
FAD or FADH2 binding
nucleoside binding
oxidoreductase activity
oxidoreductase activity, acting on CH-OH group of donors
purine nucleoside binding
Process
alcohol metabolic process
choline metabolic process
ethanolamine and derivative metabolic process
glycine betaine biosynthetic process from choline
metabolic process
oxidation reduction
small molecule metabolic process
Gene Properties
Locus tag: PA5372
Strand: -
Entrez Gene ID: 881124
Accession: NP_254059.1
GI: 15600565
Sequence start: 6047364
Sequence End: 6049049
Sequence Length: 1685
Gene Sequence: 
>PA5372
ATGTCCCAGGAATTCGACTACATCATCATCGGAGCCGGCTCTGCCGGTAACGTACTCGCTACCCGCCTCACCGAAGATGCCGACGTCAGCGTCCTGCTGCTCGAAGCCGGCGGTCCCGACTACCGCTTCGACTTCCGCACCCAGATGCCGGCGGCCCTTGCCTTCCCGCTGCAGGGGCGGCGCTACAACTGGGCCTACGAGACCGACCCCGAGCCCTACATGAACAACCGCCGCATGGAGTGCGGTCGCGGCAAGGGCCTGGGCGGCTCCTCGCTGATCAACGGCATGTGCTACATCCGCGGCAACGCCCTGGACTTCGACGGCTGGGCCAAGGAGCCGGGCCTCGAGGACTGGAGCTACCTCGACTGCCTGCCGTACTTCCGCAAGGCGGAAACCCGGGACATCGGCCCCAACGACTACCATGGCGGCGACGGCCCGGTCAGCGTGACCACGCCGAAGGCCGGCAACAACCCACTGTTCCATGCGATGGTCGAGGCCGGCGTGCAGGCCGGCTACCCGCGAACCGATGACCTCAACGGCTACCAGCAGGAAGGCTTCGGCCCCATGGACCGGACCGTCACCCCGGAGGGCCGTCGCGCCGCCACCGGGCGCGGCTACCTGGACCAGGCCCGCGGCCGGCCCAACCTGACCATCGTCACCCACGCCCTGAGCGACCGCATCCTGTTCAGCGGCAAGCGCGCCATCGGCGTCTCCTACCTGGTGGGCAACGGCGACAACCCGGTCACCGCCCACGCCCGCCGCGAAGTATTGGTGTGCAGCGGCGCGATCGCCTCGCCGCAATTGCTGCAACGCTCCGGCGTCGGCCCGGCGGCCCTGCTGCGCGACCTGGACATCCCGGTGGTGCATGACCTGCCGGGCGTCGGCGCCAACCTGCAGGATCACCTGGAACTCTACCTGCAGTACGCCTGCAAGCAGCCGGTGTCGATCTACCCGGCGACCAAATGGTGGAACCAGCCTGCCATCGGTGCCCAGTGGCTGTTCCTCGGCAAGGGCCTCGGCGCCAGCAACCAGTTCGAGGCCGGCGGCTTCATCCGAACCCGCGAAGCGTTCGAATGGCCGAACATCCAGTTCCATTTCCTCCCGGTGGCGATCAACTACAACGGCAGCAAGGGCGTGCAGGAGCACGGCTTCCAGGCGCACATGGGCTCGATGCGCTCGCCGAGCCGCGGGCGCATCCACCTGAAGTCCAGGGACCCGCGCCAGCATCCGAGCATCCTGTTCAACTACATGTCCCACGAGCAGGACTGGCAGGAGTTCCGCGACGGCATCCGGCTGACCCGCGAGATCATGAACCAGCCGGCGCTGGACCCCTATCGGGGCCGCGAGTTGAGCCCTGGGGTGAGCGTGCAGTCGGACGCCGAACTCGACGAGTTCATCCGCAACCATGCTGAGACCGCTTTCCACCCATCCTGCTCGTGCAAGATGGGCAGCGACGACATGGCGGTGGTCGATGGCCAGGGACGGGTCCATGGCATGGAAGGACTGCGAGTGGTGGATGCGTCGATCATGCCGCTGATCATCACCGGCAACCTCAATGCCACCACCATCATGATGGCCGAGAAGATCGCCGACAGGATCCGCGGTCGCCAGCCGCTGCCGCGCAGCACGGCGAAGTACTACGTGGCCGGGGATGCGCCGGTACGCGGCAACCCCGTGCGGGCCTGA
Protein Properties
Protein Residues: 561
Protein Molecular Weight: 61.8 kDa
Protein Theoretical pI: 6.92
Hydropathicity (GRAVY score): -0.414
Charge at pH 7 (predicted): -0.59
Protein Sequence: 
>PA5372
MSQEFDYIIIGAGSAGNVLATRLTEDADVSVLLLEAGGPDYRFDFRTQMPAALAFPLQGRRYNWAYETDPEPYMNNRRMECGRGKGLGGSSLINGMCYIRGNALDFDGWAKEPGLEDWSYLDCLPYFRKAETRDIGPNDYHGGDGPVSVTTPKAGNNPLFHAMVEAGVQAGYPRTDDLNGYQQEGFGPMDRTVTPEGRRAATGRGYLDQARGRPNLTIVTHALSDRILFSGKRAIGVSYLVGNGDNPVTAHARREVLVCSGAIASPQLLQRSGVGPAALLRDLDIPVVHDLPGVGANLQDHLELYLQYACKQPVSIYPATKWWNQPAIGAQWLFLGKGLGASNQFEAGGFIRTREAFEWPNIQFHFLPVAINYNGSKGVQEHGFQAHMGSMRSPSRGRIHLKSRDPRQHPSILFNYMSHEQDWQEFRDGIRLTREIMNQPALDPYRGRELSPGVSVQSDAELDEFIRNHAETAFHPSCSCKMGSDDMAVVDGQGRVHGMEGLRVVDASIMPLIITGNLNATTIMMAEKIADRIRGRQPLPRSTAKYYVAGDAPVRGNPVRA
References
External Links:
Resource Link
Genome ID: PA5372
Entrez Gene ID: 881124
NCBI Protein ID: 15600565
General Reference: PaperBLAST - Find papers about PA5372 and its homologs