Exopolyphosphatase (PA5241)

Identification
Name: Exopolyphosphatase
Synonyms:
  • ExopolyPase
  • Metaphosphatase
Gene Name: ppx
Enzyme Class:
Biological Properties
General Function: Involved in magnesium ion binding
Specific Function: Degradation of inorganic polyphosphates. Orthophosphate is released progressively from the ends of polyphosphate of circa 500 residues long, while chains of circa 15 residues compete poorly with polyphosphate as substrate
Cellular Location: Cell membrane; Peripheral membrane protein
KEGG Pathways:
KEGG Reactions:
Thumb+Thumb ↔ Thumb+Thumb+Thumb
Guanosine 3'-diphosphate 5'-triphosphate + Water ↔ Hydrogen ion + Phosphate + Guanosine 3',5'-bis(diphosphate)
ReactionCard
Thumb+Thumb ↔ Thumb+Thumb
Guanosine 3'-diphosphate 5'-triphosphate + Water ↔ Guanosine 3',5'-bis(diphosphate) + Phosphate
ReactionCard
Thumb+Thumb ↔ Thumb
Polyphosphate + Water ↔ Phosphate
ReactionCard
SMPDB Reactions: Not Available
PseudoCyc/BioCyc Reactions:
Thumb+Thumb → Thumb+2 Thumb
Water + Pyrophosphate → Hydrogen ion + 2 Phosphate
ReactionCard
Thumb+Thumb ↔ Thumb+Thumb+Thumb
Guanosine 3'-diphosphate 5'-triphosphate + Water ↔ Hydrogen ion + Phosphate + Guanosine 3',5'-bis(diphosphate)
ReactionCard
Complex Reactions:
Thumb+Thumb → Thumb+Thumb+Thumb
Water + Triphosphate → Hydrogen ion + Phosphate + Pyrophosphate
ReactionCard
(Polyphosphate)(n)+Thumb → (polyphosphate)(n-1)+Thumb
(Polyphosphate)(n) + Water → (polyphosphate)(n-1) + Inorganic phosphate
ReactionCard
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB001005Guanosine 3',5'-bis(diphosphate)MetaboCard
PAMDB001003Guanosine 3'-diphosphate 5'-triphosphateMetaboCard
PAMDB001633Hydrogen ionMetaboCard
PAMDB001776Inorganic phosphateMetaboCard
PAMDB000383PhosphateMetaboCard
PAMDB000633PyrophosphateMetaboCard
PAMDB000496TriphosphateMetaboCard
PAMDB000142WaterMetaboCard
GO Classification:
Function
binding
catalytic activity
cation binding
exopolyphosphatase activity
hydrolase activity
hydrolase activity, acting on acid anhydrides
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
ion binding
magnesium ion binding
metal ion binding
pyrophosphatase activity
Process
cellular metabolic process
metabolic process
phosphate metabolic process
phosphorus metabolic process
polyphosphate catabolic process
polyphosphate metabolic process
Gene Properties
Locus tag: PA5241
Strand: +
Entrez Gene ID: 877947
Accession: NP_253928.1
GI: 15600434
Sequence start: 5900879
Sequence End: 5902399
Sequence Length: 1520
Gene Sequence: 
>PA5241
ATGGACTTGCAAAGCATGCCGCAAAAACCTGCCGAGGCATTCCCGCTGATTGCCGCCCTGGACCTGGGCTCCAACAGTTTCCACCTCTGTCTGGCCAAGGCCAATATCCACGGCGAAGTCCGCATCCTCGAACGGCTGGGCGAGAAGGTCCAACTGGCCGCCGGCCTCGACGAGGAGCGCAATCTCAGCGAAGAGGCCACCCAGCGCGGCCTCGACTGCCTGCGCCGCTTCGCCCAGTTCATCAGCGGCATGCCCCAGGGTTCCGTACGCGTGGTCGCGACCAACGCCTTGCGCGAGGCGCGCAACCGCAGCGATTTCATCCGTCGTGCGGAAGAGGTTCTCGGCCATCCCGTGGAAGTCATCTCCGGCCGCGAGGAAGCCCGCCTGATCTACCTCGGCGTCGCCAACAGCATGCCCGACAGCGGCGGTCGCCGGCTGGTCAGCGACATCGGCGGCGGCAGCACCGAGTTCATCATCGGCCAGGGTTTCGAGTCCGAGCTGCGGGAAAGCCTGCAGATGGGTTGCGTCAGCTACACCCAACGCTACTTCCGCGACGGCAAGATCACCCCGGCCCGCTACGCCCAGGCGTACACTGCTGCACGCCTGGAACTGATGGGCATCGAGAACAGCCTGCGGCGCCTCGGCTGGCAACAGGCGGTCGGCGCCTCCGGCACCATCCGCGCAGTGGCGCTGGCGATCAAGGCCGGCGGCCACGGCAACGGCGAGATCAGCCCGGACGGACTGGCCTGGCTGAAGCGCAAGGTGCTCAAGCTCGGCGACGTGGAGAAGCTCGATCTGGAAGGGATCAAGCCGGACCGCCGGACCATCTTCCCGGCCGGACTGGCCATTCTCGAAGCGATCTTCGACGCGCTGGAACTGGAACAGATGGTTCACTCCGAGGGCGCCCTGCGCGAAGGCGTTCTCTACGACCTGGTCGGCCGTCACCAGCACGAGGACGTGCGCGAACGCACCATCAGCTCGCTGATGCAGCGCTACCACGTCGATCCGGAGCAGGCTTCGCGGGTGGAGGCCAAGGCCCTCAAGGTGCTTGCCGAAGTCGGCGACGCCTGGGAGCTGAACGGCGAACTGCACCGCGACCTGCTGAGCTGGGGCGCACGGGTCCACGAGATCGGCCTGGACATCGCTCATTACCACTACCACAAGCACGGCGCCTACCTGATCGAGCACTCCGACCTGGCTGGCTTCTCGCGCCAGGACCAGCAGATGCTGTCGCTACTGGTACGCGGCCACCGCCGCAACATTCCGGCGGACAAGCTGGCGGAGTTCGCCGAGGAAGGCGACAAGCTGGTACGCCTGTGCATCGTGCTGCGCTTCGCGATCCTCTTCCACCACATTCGCGGCACCCAGGAAATGCCCTCGGTGCGTCTGAAGGCAGAGCCCAAGAGCCTTTCGGTGACCTTCCCCGAGGGCTGGCTGGAAGCCAACCCGCTGACCCAAGCCGACTTCGCCCAGGAAGCCGAATGGCTCAAGCGGGTCGGCTACAGCCTCAACGTGCGGTAA
Protein Properties
Protein Residues: 506
Protein Molecular Weight: 56.4 kDa
Protein Theoretical pI: 6.7
Hydropathicity (GRAVY score): -0.271
Charge at pH 7 (predicted): -2.76
Protein Sequence: 
>PA5241
MDLQSMPQKPAEAFPLIAALDLGSNSFHLCLAKANIHGEVRILERLGEKVQLAAGLDEERNLSEEATQRGLDCLRRFAQFISGMPQGSVRVVATNALREARNRSDFIRRAEEVLGHPVEVISGREEARLIYLGVANSMPDSGGRRLVSDIGGGSTEFIIGQGFESELRESLQMGCVSYTQRYFRDGKITPARYAQAYTAARLELMGIENSLRRLGWQQAVGASGTIRAVALAIKAGGHGNGEISPDGLAWLKRKVLKLGDVEKLDLEGIKPDRRTIFPAGLAILEAIFDALELEQMVHSEGALREGVLYDLVGRHQHEDVRERTISSLMQRYHVDPEQASRVEAKALKVLAEVGDAWELNGELHRDLLSWGARVHEIGLDIAHYHYHKHGAYLIEHSDLAGFSRQDQQMLSLLVRGHRRNIPADKLAEFAEEGDKLVRLCIVLRFAILFHHIRGTQEMPSVRLKAEPKSLSVTFPEGWLEANPLTQADFAQEAEWLKRVGYSLNVR
References
External Links:
Resource Link
Genome ID: PA5241
Entrez Gene ID: 877947
NCBI Protein ID: 15600434
General Reference: PaperBLAST - Find papers about PA5241 and its homologs