Aminomethyltransferase (PA5215)

Identification
Name: Aminomethyltransferase
Synonyms:
  • Glycine cleavage system T protein
Gene Name: gcvT
Enzyme Class:
Biological Properties
General Function: Involved in aminomethyltransferase activity
Specific Function: The glycine cleavage system catalyzes the degradation of glycine
Cellular Location: Not Available
KEGG Pathways:
KEGG Reactions:
Thumb+Thumb → Thumb+Thumb
N5-Formyl-H4F + Hydrogen ion → Water + 5,10-Methenyltetrahydrofolate
ReactionCard
Thumb+Thumb+Thumb ↔ Thumb+Thumb+Thumb+Thumb+Thumb
Glycine + Tetrahydrofolic acid + NAD ↔ 5,10-Methylene-THF + Ammonia + Carbon dioxide + NADH + Hydrogen ion
ReactionCard
Thumb ↔ Thumb+Thumb
N5-Formyl-H4F ↔ 5,10-Methenyltetrahydrofolate + Water
ReactionCard
S-Aminomethyldihydrolipoylprotein+Thumb+S-Aminomethyldihydrolipoylprotein ↔ Dihydrolipoylprotein+Thumb+Thumb
S-Aminomethyldihydrolipoylprotein + Tetrahydrofolic acid + S-Aminomethyldihydrolipoylprotein ↔ Dihydrolipoylprotein + 5,10-Methylene-THF + Ammonia
ReactionCard
Thumb+Thumb+Thumb → Thumb+Thumb+Thumb+Thumb+Thumb
NAD + Glycine + Tetrahydrofolic acid → Hydrogen ion + 5,10-Methylene-THF + Ammonia + Carbon dioxide + NADH
ReactionCard
SMPDB Reactions:
S-Aminomethyldihydrolipoylprotein;+Tetrahydrofolic acid+Thumb ↔ 5,10-Methylene-THF+Thumb+dihydrolipoylprotein+Thumb
S-Aminomethyldihydrolipoylprotein; + Tetrahydrofolic acid + Tetrahydrofolic acid ↔ 5,10-Methylene-THF + Ammonia + dihydrolipoylprotein + 5,10-Methylene-THF
ReactionCard
Thumb+Thumb → N5-Formyl-THF+Thumb
Water + 5,10-Methenyltetrahydrofolic acid → N5-Formyl-THF + N5-Formyl-H4F
ReactionCard
PseudoCyc/BioCyc Reactions:
Thumb+Thumb → Thumb+Thumb
N5-Formyl-H4F + Hydrogen ion → Water + 5,10-Methenyltetrahydrofolate
ReactionCard
Thumb+Thumb+Thumb → Thumb+Thumb+Thumb+Thumb+Thumb
NAD + Glycine + Tetrahydrofolic acid → Hydrogen ion + 5,10-Methylene-THF + Ammonia + Carbon dioxide + NADH
ReactionCard
Complex Reactions:
Thumb+Thumb+Thumb → Thumb+Thumb+Thumb+Thumb
Glycine + NAD + Tetrahydrofolic acid → Carbon dioxide + 5,10-Methylene-THF + NADH + Ammonium
ReactionCard
[Protein]-S(8)-aminomethyldihydrolipoyllysine+Thumb → [protein]-dihydrolipoyllysine+Thumb+Thumb
[Protein]-S(8)-aminomethyldihydrolipoyllysine + Tetrahydrofolic acid → [protein]-dihydrolipoyllysine + 5,10-Methylene-THF + Ammonia
ReactionCard
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB0015855,10-MethenyltetrahydrofolateMetaboCard
PAMDB0061845,10-Methenyltetrahydrofolic acidMetaboCard
PAMDB0003535,10-Methylene-THFMetaboCard
PAMDB000017AmmoniaMetaboCard
PAMDB001595AmmoniumMetaboCard
PAMDB000568Carbon dioxideMetaboCard
PAMDB004304DihydrolipoylproteinMetaboCard
PAMDB000046GlycineMetaboCard
PAMDB001633Hydrogen ionMetaboCard
PAMDB000421N5-Formyl-H4FMetaboCard
PAMDB000197NADMetaboCard
PAMDB000398NADHMetaboCard
PAMDB000424Tetrahydrofolic acidMetaboCard
PAMDB000142WaterMetaboCard
GO Classification:
Component
cell part
cytoplasm
intracellular part
Function
aminomethyltransferase activity
catalytic activity
methyltransferase activity
transferase activity
transferase activity, transferring one-carbon groups
Process
cellular amino acid and derivative metabolic process
cellular amino acid metabolic process
cellular metabolic process
glycine catabolic process
glycine metabolic process
metabolic process
serine family amino acid metabolic process
Gene Properties
Locus tag: PA5215
Strand: -
Entrez Gene ID: 880638
Accession: NP_253902.1
GI: 15600408
Sequence start: 5871667
Sequence End: 5872749
Sequence Length: 1082
Gene Sequence: 
>PA5215
ATGGGATTGCGCACCCCGCTTTACGAGCTGCACGTCGCGCTCGGCGCCAAGATGGTCGATTTCGGCGGTTGGGACATGCCGCTGCACTACGGTTCGCAGGTCGAGGAGCACCATCAGGTTCGGCGTGACTGCGGCGTCTTCGACGTGTCCCACATGACCGTGGTCGACGTCGCCGGCGAGCAGGCCACGGCCTATCTGCAGCATCTCCTGGCGAACGACGTGGCGCGTCTCGGCGAAACCGGCAAGGCGCTCTACAGCGCGATGCTCAACGAAGAGGGCGGGGTGGTCGACGACCTGATCGTCTACCTGACCGAGCACGGCTACCGGGTGGTGGTCAATGCTTCCACCCGCGACAAGGACATCGCCTGGATGCAGGCGCAGGCCGCCGGCTTCAAGGTCGACCTGCAGGAACGCGGCGACCTGGCGATGCTCGCCATCCAGGGCCCCAACGCCCGCGTGCACAGCTCCGAACTGGTGTCCCCGGCACGCGCCGCGCTGATACGCGAACTCAAGCCGTTCCAGGGCCGTGCCGAGGGCGACTGGTTCATCGCCCGCACCGGCTACACCGGCGAGGACGGCCTGGAAATCATGCTGCCGGCCGCCGAGGCGCCGGGTTTCCTCAATGAGCTGGTTGGCGCCGGGATCTCCCCGGCGGGCCTGGGTGCGCGCGATACGCTGCGCCTGGAGGCCGGGCTCAATCTCTACGGCCAGGACATGGACGAAAGCGTTTCCCCGCTTGCCGCCAACATGGGCTGGACCGTAGCCTGGGAGCCGGTTGCGCGGGACTTCGTCGGCCGCCGCGCGCTGGAAGCGCAGAAGGCCGCCGGCGACCAGCCGAAGCTGGTCGGCCTGGTACTGGAGGAGCGCGGCGTGCTGCGCGCCCACCAGGTGGTGCGGGTAGCTGGCATTGGTGAGGGGGAGATCACCAGCGGCAGCTTTTCGCCTACCCTGAACAAGTCCATCGCGCTGGCCCGCGTGCCGGCCGCCACCGGCGACCGCGCCGAGGTGGAAATCCGCGGCAAGTGGTACCCGGTACGGGTGGTCCAGCCCAGTTTCGTGCGTCACGGCAAGCCCCTGATCTAA
Protein Properties
Protein Residues: 360
Protein Molecular Weight: 38.9 kDa
Protein Theoretical pI: 5.42
Hydropathicity (GRAVY score): -0.081
Charge at pH 7 (predicted): -8.61
Protein Sequence: 
>PA5215
MGLRTPLYELHVALGAKMVDFGGWDMPLHYGSQVEEHHQVRRDCGVFDVSHMTVVDVAGEQATAYLQHLLANDVARLGETGKALYSAMLNEEGGVVDDLIVYLTEHGYRVVVNASTRDKDIAWMQAQAAGFKVDLQERGDLAMLAIQGPNARVHSSELVSPARAALIRELKPFQGRAEGDWFIARTGYTGEDGLEIMLPAAEAPGFLNELVGAGISPAGLGARDTLRLEAGLNLYGQDMDESVSPLAANMGWTVAWEPVARDFVGRRALEAQKAAGDQPKLVGLVLEERGVLRAHQVVRVAGIGEGEITSGSFSPTLNKSIALARVPAATGDRAEVEIRGKWYPVRVVQPSFVRHGKPLI
References
External Links:
Resource Link
Genome ID: PA5215
Entrez Gene ID: 880638
NCBI Protein ID: 15600408
General Reference: PaperBLAST - Find papers about PA5215 and its homologs