Glutaredoxin-3 (PA5129)

Identification
Name: Glutaredoxin-3
Synonyms:
  • Grx3
Gene Name: grxC
Enzyme Class: Not Available
Biological Properties
General Function: Involved in electron carrier activity
Specific Function: The disulfide bond functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase. In addition, it is also involved in reducing some disulfides in a coupled system with glutathione reductase
Cellular Location: Not Available
KEGG Pathways:
    KEGG Reactions: Not Available
    SMPDB Reactions: Not Available
    PseudoCyc/BioCyc Reactions:
    glutaredoxin+2 Thumb → glutaredoxin+Thumb
    glutaredoxin + 2 Glutathione → glutaredoxin + Glutathione disulfide
    ReactionCard
    Complex Reactions:
    glutaredoxin+Thumb → Thumb+glutaredoxin+Thumb
    glutaredoxin + Uridine 5'-diphosphate → dUDP + glutaredoxin + Water
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    Thumb+glutaredoxin → Thumb+glutaredoxin+Thumb
    Guanosine diphosphate + glutaredoxin → dGDP + glutaredoxin + Water
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    Thumb+glutaredoxin → Thumb+glutaredoxin+Thumb
    CDP + glutaredoxin → dCDP + glutaredoxin + Water
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    Thumb+glutaredoxin → Thumb+glutaredoxin+Thumb
    ADP + glutaredoxin → dADP + glutaredoxin + Water
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    glutaredoxin+Thumb → glutaredoxin+2 Thumb+Thumb+Thumb
    glutaredoxin + Phosphoadenosine phosphosulfate → glutaredoxin + 2 Hydrogen ion + Adenosine 3',5'-diphosphate + Sulfite
    ReactionCard
    glutaredoxin+2 Thumb → glutaredoxin+Thumb
    glutaredoxin + 2 Glutathione → glutaredoxin + Glutathione disulfide
    ReactionCard
    Transports: Not Available
    Metabolites:
    PAMDB IDNameView
    PAMDB000022Adenosine 3',5'-diphosphateMetaboCard
    PAMDB000345ADPMetaboCard
    PAMDB000415CDPMetaboCard
    PAMDB001728dADPMetaboCard
    PAMDB000307dCDPMetaboCard
    PAMDB000209dGDPMetaboCard
    PAMDB000221dUDPMetaboCard
    PAMDB000048GlutathioneMetaboCard
    PAMDB001629Glutathione disulfideMetaboCard
    PAMDB000296Guanosine diphosphateMetaboCard
    PAMDB001633Hydrogen ionMetaboCard
    PAMDB000269Phosphoadenosine phosphosulfateMetaboCard
    PAMDB000100SulfiteMetaboCard
    PAMDB000123Uridine 5'-diphosphateMetaboCard
    PAMDB000142WaterMetaboCard
    GO Classification:
    Function
    catalytic activity
    disulfide oxidoreductase activity
    electron carrier activity
    oxidoreductase activity
    oxidoreductase activity, acting on a sulfur group of donors
    protein disulfide oxidoreductase activity
    Process
    cell redox homeostasis
    cellular homeostasis
    cellular process
    Gene Properties
    Locus tag: PA5129
    Strand: -
    Entrez Gene ID: 877828
    Accession: NP_253816.1
    GI: 15600322
    Sequence start: 5777134
    Sequence End: 5777388
    Sequence Length: 254
    Gene Sequence: 
    >PA5129
ATGCCGCCCGTCGTGATCTACACCACCGCCTGGTGTCCGTACTGCATCCGCGCCAAGCAGTTGCTGCAACGCAAGGGCGTGGACTTCCAGGAGATCGCCTGCGACGGCAAGCCCGAACTGCGCGCCGAGCTGGCACGCAAGGCGGGATCGACCACCGTGCCGCAGATCTGGATCGGCGAGACCCATGTCGGCGGCTGCGACGACCTTCATGCACTGGAGCGCGCCGGCAAGCTGGACGCGCTGCTGTCTGCCTGA
    Protein Properties
    Protein Residues: 84
    Protein Molecular Weight: 9.2 kDa
    Protein Theoretical pI: 7.29
    Hydropathicity (GRAVY score): -0.087
    Charge at pH 7 (predicted): 0.34
    Protein Sequence: 
    >PA5129
MPPVVIYTTAWCPYCIRAKQLLQRKGVDFQEIACDGKPELRAELARKAGSTTVPQIWIGETHVGGCDDLHALERAGKLDALLSA
    References
    External Links:
    Resource Link
    Genome ID: PA5129
    Entrez Gene ID: 877828
    NCBI Protein ID: 15600322
    General Reference: PaperBLAST - Find papers about PA5129 and its homologs