Histidine biosynthesis bifunctional protein hisIE (PA5066)

Identification
Name: Histidine biosynthesis bifunctional protein hisIE
Synonyms:
  • Phosphoribosyl-AMP cyclohydrolase
  • PRA-CH
  • Phosphoribosyl-ATP pyrophosphatase
  • PRA-PH
Gene Name: hisI
Enzyme Class:
Biological Properties
General Function: Involved in phosphoribosyl-AMP cyclohydrolase activity
Specific Function: 1-(5-phosphoribosyl)-ATP + H(2)O = 1-(5- phosphoribosyl)-AMP + diphosphate
Cellular Location: Cytoplasm
KEGG Pathways:
KEGG Reactions:
Thumb+Thumb ↔ Thumb
Water + Phosphoribosyl-AMP ↔ PhosphoribosylformiminoAICAR-phosphate
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Thumb+Thumb ↔ Thumb+Thumb+Thumb
Water + Phosphoribosyl-ATP ↔ Hydrogen ion + Pyrophosphate + Phosphoribosyl-AMP
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Thumb+Thumb ↔ Thumb+Thumb
Phosphoribosyl-ATP + Water ↔ Phosphoribosyl-AMP + Pyrophosphate
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Thumb+Thumb → Thumb+Thumb+Thumb
Phosphoribosyl-ATP + Water → Hydrogen ion + Phosphoribosyl-AMP + Pyrophosphate
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SMPDB Reactions:
Phosphoribosyl-ATP+Thumb+Thumb → Thumb+Pyrophosphate+Thumb
Phosphoribosyl-ATP + Water + Phosphoribosyl-ATP → Hydrogen ion + Pyrophosphate + Phosphoribosyl-AMP
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Thumb+Thumb → Thumb
Phosphoribosyl-AMP + Water → AICAR
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PseudoCyc/BioCyc Reactions:
Thumb+Thumb ↔ Thumb
Water + Phosphoribosyl-AMP ↔ PhosphoribosylformiminoAICAR-phosphate
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Thumb+Thumb ↔ Thumb+Thumb+Thumb
Water + Phosphoribosyl-ATP ↔ Hydrogen ion + Pyrophosphate + Phosphoribosyl-AMP
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Thumb+Thumb → Thumb+Thumb+Thumb
Phosphoribosyl-ATP + Water → Hydrogen ion + Phosphoribosyl-AMP + Pyrophosphate
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Complex Reactions: Not Available
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB0035851-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamideMetaboCard
PAMDB000407AICARMetaboCard
PAMDB001633Hydrogen ionMetaboCard
PAMDB000630Phosphoribosyl-AMPMetaboCard
PAMDB000631Phosphoribosyl-ATPMetaboCard
PAMDB000837PhosphoribosylformiminoAICAR-phosphateMetaboCard
PAMDB000633PyrophosphateMetaboCard
PAMDB000142WaterMetaboCard
GO Classification:
Function
catalytic activity
cyclohydrolase activity
hydrolase activity
hydrolase activity, acting on acid anhydrides
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
phosphoribosyl-AMP cyclohydrolase activity
phosphoribosyl-ATP diphosphatase activity
pyrophosphatase activity
Process
cellular amino acid and derivative metabolic process
cellular amino acid metabolic process
cellular metabolic process
histidine biosynthetic process
histidine family amino acid metabolic process
histidine metabolic process
metabolic process
Gene Properties
Locus tag: PA5066
Strand: +
Entrez Gene ID: 878019
Accession: NP_253753.1
GI: 15600259
Sequence start: 5705794
Sequence End: 5706198
Sequence Length: 404
Gene Sequence: 
>PA5066
ATGAAAGACTGGCTGGATGAGATTCACTGGAACGCCGACGGCCTGGTCCCGGCGATCGCCCAGGATCACGAGACCGGGCGCGTGCTGATGATGGCCTGGATGAACCGCGAGGCGCTGGCCCTGACCGCCAGCGAGAACCGTGCAATCTATTGGTCGCGTTCGCGTGGCAAGCTGTGGCGCAAGGGCGAGGAGTCCGGGCACGTGCAGAAGCTGCACGAACTGCGTCTGGACTGCGACGCCGACGTGGTCATCCTGATGGTCGAGCAGGTCGGCGGGATCGCCTGCCATACCGGCCGGGAAAGCTGTTTCTACCGCGTCTTCGAGAACGGCGCCTGGAAGACCGTCGATCCGGTGCTGAAGGACCCGGACGCTATCTACGAACACGCAGGACACCACCATGAGTGA
Protein Properties
Protein Residues: 134
Protein Molecular Weight: 15.4 kDa
Protein Theoretical pI: 6.01
Hydropathicity (GRAVY score): -0.465
Charge at pH 7 (predicted): -4.93
Protein Sequence: 
>PA5066
MKDWLDEIHWNADGLVPAIAQDHETGRVLMMAWMNREALALTASENRAIYWSRSRGKLWRKGEESGHVQKLHELRLDCDADVVILMVEQVGGIACHTGRESCFYRVFENGAWKTVDPVLKDPDAIYEHAGHHHE
References
External Links:
Resource Link
Genome ID: PA5066
Entrez Gene ID: 878019
NCBI Protein ID: 15600259
General Reference: PaperBLAST - Find papers about PA5066 and its homologs