Phosphoribosylamine--glycine ligase (PA4855)

Identification
Name: Phosphoribosylamine--glycine ligase
Synonyms:
  • GARS
  • Glycinamide ribonucleotide synthetase
  • Phosphoribosylglycinamide synthetase
Gene Name: purD
Enzyme Class:
Biological Properties
General Function: Involved in ATP binding
Specific Function: ATP + 5-phospho-D-ribosylamine + glycine = ADP + phosphate + N(1)-(5-phospho-D-ribosyl)glycinamide
Cellular Location: Not Available
KEGG Pathways:
KEGG Reactions:
Thumb+Thumb+Thumb ↔ Thumb+Thumb+Thumb+Thumb
Adenosine triphosphate + Glycine + 5-Phosphoribosylamine ↔ ADP + Glycineamideribotide + Hydrogen ion + Phosphate
ReactionCard
Thumb+Thumb+Thumb ↔ Thumb+Thumb+Thumb
Adenosine triphosphate + 5-Phosphoribosylamine + Glycine ↔ ADP + Phosphate + Glycineamideribotide
ReactionCard
Thumb+Thumb+Thumb ↔ Thumb+Thumb+Thumb+Thumb
Adenosine triphosphate + 5-Phosphoribosylamine + Glycine ↔ Hydrogen ion + ADP + Phosphate + Glycineamideribotide
ReactionCard
SMPDB Reactions:
5-Phosphoribosylamine+Thumb+Thumb+Thumb → Thumb+Thumb+Adenosine diphosphate+Thumb+Thumb
5-Phosphoribosylamine + Glycine + Adenosine triphosphate + 5-Phosphoribosylamine → N1-(5-phospho-β-D-ribosyl)glycinamide + Phosphate + Adenosine diphosphate + Hydrogen ion + ADP
ReactionCard
PseudoCyc/BioCyc Reactions:
Thumb+Thumb+Thumb ↔ Thumb+Thumb+Thumb+Thumb
Adenosine triphosphate + Glycine + 5-Phosphoribosylamine ↔ ADP + Glycineamideribotide + Hydrogen ion + Phosphate
ReactionCard
Thumb+Thumb+Thumb ↔ Thumb+Thumb+Thumb+Thumb
Adenosine triphosphate + 5-Phosphoribosylamine + Glycine ↔ Hydrogen ion + ADP + Phosphate + Glycineamideribotide
ReactionCard
Complex Reactions:
Thumb+Thumb+Thumb → Thumb+Thumb+Thumb
Adenosine triphosphate + 5-Phosphoribosylamine + Glycine → ADP + Inorganic phosphate + 5'-Phospho-ribosylglycinamide
ReactionCard
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB0034315'-Phospho-ribosylglycinamideMetaboCard
PAMDB0002655-PhosphoribosylamineMetaboCard
PAMDB000148Adenosine triphosphateMetaboCard
PAMDB000345ADPMetaboCard
PAMDB000046GlycineMetaboCard
PAMDB000422GlycineamideribotideMetaboCard
PAMDB001633Hydrogen ionMetaboCard
PAMDB001776Inorganic phosphateMetaboCard
PAMDB006363N1-(5-phospho-β-D-ribosyl)glycinamideMetaboCard
PAMDB000383PhosphateMetaboCard
GO Classification:
Function
adenyl nucleotide binding
adenyl ribonucleotide binding
ATP binding
binding
catalytic activity
ligase activity
ligase activity, forming carbon-nitrogen bonds
nucleoside binding
phosphoribosylamine-glycine ligase activity
purine nucleoside binding
Process
cellular aromatic compound metabolic process
cellular metabolic process
metabolic process
nucleobase metabolic process
purine base biosynthetic process
purine base metabolic process
Gene Properties
Locus tag: PA4855
Strand: +
Entrez Gene ID: 878236
Accession: NP_253542.1
GI: 15600048
Sequence start: 5450757
Sequence End: 5452046
Sequence Length: 1289
Gene Sequence: 
>PA4855
ATGAACGTACTCATCATCGGCAGCGGCGGTCGTGAACATGCCCTGGCCTGGAAAGTCGCCCAGGACCCGCGCGTGGCGAAGGTCTTCGTCGCCCCGGGCAACGCCGGCACCGCCACCGAAGCCAAGTGCGAGAACGTCGCCATCGACGTGCTGGCCCTGGAGCAACTGGCCGACTTCGCCGCGAAGAACGTCCAGTTGACCATCGTCGGTCCCGAGGCGCCGCTGGTGGCAGGCGTGGTCGACCTGTTCCGCGAGCGCGGCCTGGATATCTTCGGCCCGACCGCCGGCGCCGCCCAGCTGGAAGGCTCGAAGGCCTTCACCAAGGACTTCCTCGCCCGCCACCGGATCCCCACCGCCGCCTATCGCAACTTCACCGAGGTCGAGCCGGCCCTGGCCTACCTGCACGAGCAGGGCGCGCCCATCGTCATCAAGGCCGATGGCCTGGCCGCGGGCAAGGGCGTGATCGTCGCCATGAACCTGGACGAAGCCGAAGCCGCCGTGCGCGACATGCTCGCCGGCAATGCCTTCGGCGACGCCGGCTCGCGCGTGGTGATCGAGGAGTTCCTCGATGGCGAGGAGGCCAGCTTCATCGTCATGGTCGACGGCCAGAACGTGCTGCCGATGGCCACCAGCCAGGACCACAAGCGCGTCGGCGATGGCGACAGCGGGCCGAACACCGGCGGCATGGGCGCCTACTCGCCGGCCCCGGTGGTCACCGCCGAGGTCCACCAGCGGGTGCTGGACGAAGTGATCTACCCGACCGTGCGCGGCATGGCCGAGGAAGGCAACGTCTATACCGGCTTCCTCTATGCCGGCCTGATGATCGACAAGAGCGGCGCGCCCAAGGTCATCGAATTCAACTGCCGCTTCGGCGATCCGGAAACCCAGCCGATCATGGTCCGCCTGGAGTCCTCCCTGGTCCTGCTGGTCGAGGCCGCCCTGGCCAAGGCGCTGGACAAGGTCGAGGCGACCTGGGACCCGCGTCCGACCGTGGGCGTGGTACTGGCCGCCGGCGGCTATCCGGGCGACTACGCCAAGGGCGAGGTCATCGAAGGCCTGGCCGAGGCCGCCGCGCTGGACGGCAAGGTGTTCCACGCCGGCACCGCGCTGAAGGATGGCCAGGTGGTCACCTCCGGCGGCCGCGTGCTCTGTGCCACCGCCATCGGCGAGAGCGTGTCCGCCGCCCAGCAACAGGCCTATCGCCTGGCCGAGAAGATCCGCTGGAACGGCTGCTTCTACCGCAAGGACATCGGCTACCGTGCCATCGCCCGCGAGCGCGGCGAGTCCTGA
Protein Properties
Protein Residues: 429
Protein Molecular Weight: 45.2 kDa
Protein Theoretical pI: 4.68
Hydropathicity (GRAVY score): 0.057
Charge at pH 7 (predicted): -14.66
Protein Sequence: 
>PA4855
MNVLIIGSGGREHALAWKVAQDPRVAKVFVAPGNAGTATEAKCENVAIDVLALEQLADFAAKNVQLTIVGPEAPLVAGVVDLFRERGLDIFGPTAGAAQLEGSKAFTKDFLARHRIPTAAYRNFTEVEPALAYLHEQGAPIVIKADGLAAGKGVIVAMNLDEAEAAVRDMLAGNAFGDAGSRVVIEEFLDGEEASFIVMVDGQNVLPMATSQDHKRVGDGDSGPNTGGMGAYSPAPVVTAEVHQRVLDEVIYPTVRGMAEEGNVYTGFLYAGLMIDKSGAPKVIEFNCRFGDPETQPIMVRLESSLVLLVEAALAKALDKVEATWDPRPTVGVVLAAGGYPGDYAKGEVIEGLAEAAALDGKVFHAGTALKDGQVVTSGGRVLCATAIGESVSAAQQQAYRLAEKIRWNGCFYRKDIGYRAIARERGES
References
External Links:
Resource Link
Genome ID: PA4855
Entrez Gene ID: 878236
NCBI Protein ID: 15600048
General Reference: PaperBLAST - Find papers about PA4855 and its homologs