2,4-dienoyl-CoA reductase FadH2 (PA4814)

Identification
Name: 2,4-dienoyl-CoA reductase FadH2
Synonyms: Not Available
Gene Name: fadH2
Enzyme Class: Not Available
Biological Properties
General Function: oxidation-reduction process
Specific Function: oxidoreductase activity, flavin adenine dinucleotide binding, catalytic activity, FMN binding, 2,4-dienoyl-CoA reductase (NADPH) activity
Cellular Location: Cytoplasmic
KEGG Pathways:
  • unsaturated, even numbered fatty acid β-oxidation PWY-5138
    KEGG Reactions: Not Available
    SMPDB Reactions: Not Available
    PseudoCyc/BioCyc Reactions:
    Thumb
    trans-Δ2-decenoyl-CoA + NADP+ = trans-Δ2, cis-Δ4-decadienoyl-CoA + NADPH + H+
    ReactionCard
    PAMDB120164+PAMDB110539+PAMDB001633 → PAMDB120582+PAMDB110541
    2-trans, 4-trans-undecadienoyl-CoA + NADPH + Hydrogen ion → 3-trans-undecenoyl-CoA + NADP+
    ReactionCard
    PAMDB120105+PAMDB110539+PAMDB001633 → PAMDB120582+PAMDB110541
    2-trans, 4-cis-undecadienoyl-CoA + NADPH + Hydrogen ion → 3-trans-undecenoyl-CoA + NADP+
    ReactionCard
    PAMDB120264+PAMDB110539+PAMDB001633 → PAMDB120225+PAMDB110541
    2-trans,4-trans-tetradecadienoyl-CoA + NADPH + Hydrogen ion → 3-trans-tetradecenoyl-CoA + NADP+
    ReactionCard
    TETRADEHYDROACYL-COA+PAMDB110539 → Trans-3-enoyl-CoAs+PAMDB110541
    TETRADEHYDROACYL-COA + NADPH → Trans-3-enoyl-CoAs + NADP+
    ReactionCard
    TRANS-D2-ENOYL-COA+PAMDB110541 → TETRADEHYDROACYL-COA+PAMDB110539+PAMDB001633
    TRANS-D2-ENOYL-COA + NADP+ → TETRADEHYDROACYL-COA + NADPH + Hydrogen ion
    ReactionCard
    2-trans-4-cis-dienoyl-CoAs+PAMDB110539 → Trans-3-enoyl-CoAs+PAMDB110541+PAMDB001633
    2-trans-4-cis-dienoyl-CoAs + NADPH → Trans-3-enoyl-CoAs + NADP+ + Hydrogen ion
    ReactionCard
    Complex Reactions: Not Available
    Transports: Not Available
    Metabolites: Not Available
    GO Classification:
    Function
    oxidoreductase activity
    flavin adenine dinucleotide binding
    catalytic activity
    FMN binding
    2,4-dienoyl-CoA reductase (NADPH) activity
    Process
    oxidation-reduction process
    Gene Properties
    Locus tag: PA4814
    Strand: +
    Entrez Gene ID: 880156
    Accession: NP_253501.1
    GI: 15600007
    Sequence start: 5403305
    Sequence End: 5405350
    Sequence Length: 2045
    Gene Sequence: 
    >PA4814
ATGCGCACCCCCTACCCGCCGCTCGCCGCCGCTCCCTATCCGCACCTGCTGGCCCCGCTGGACCTGGGCTTCACCCGTCTGCGCAACCGCGTGGTGATGGGTTCGATGCACACCGGGCTGGAGGATCGTCTGTGGGACTTCGGCAAGCTCGCTGCCTACTACCGCGAGCGTGCCCGGGGCGGCGTCGGGCTGATCGTCACCGGCGGTTTCGCGCCCTGCCGCGAAGGTTGGCTGCTGCCCTTCGGCAGCAGCCTCACCAGCGCCCTGGAGGTGCCCGCCCATCGTCGCCTGACCCAGGCGGTGCATGCCGAGGGCGGCAAGATCCTGCTGCAGATCCTCCACGCCGGGCGCTATGGCTACCACCCGATGGCGGTGTCCGCCTCGCCGTTGAAGTCGCCGATCAGTTGGTTCACCCCGCGCGAGCTCTCCGAGCGCGGCATCCGCAAGACCATCCGCGCCTTCGTCCGTTGCGCGCGGCTGGCCAAGGCCGCCGCCTACGACGGCGTGGAGGTGATGGGCAGCGAAGGCTACCTGCTCAACCAGTTCCTCTGCCCGCGCACCAATCGCCGCGACGACCAGTGGGGCGGCCCGCTGGAAAACCGCATGCGCCTGGCGCTGGAGATCGTCCGCGGCATCCGGCGGATCGTCGGCCAACGCTTCATCCTCTGCTATCGCCTGTCGCTGCTCGACCTGGTCGAGGGCGGCAATACCTGGGACGAGGTGCGGCGCATCGCCCTGGCCCTGGAGGAAGCCGGAATCACCCTGCTCAACACCGGCATCGGCTGGCACGAGTCGCGCGTGCCGACCATCGTCACCTCGGTGCCGCGCGCGGCCTTCGCCGAGGTCAGCGCACGGCTGCGCCACGAGCTGAAGGTGCCGGTGATCGCCAGTAACCGGATCAACACCCCCGAGGTCGCCGAATCCCTGCTCGCCACCGACAAGGCCGACCTGGTGTCGATGGCCCGGCCGCTGCTGGCCGACCCGCAGTTCGTGGCCAAGGCCGGCGCCGGCCGGGCCGAGGAGATCAACACCTGCATCGCCTGCAACCAGGCCTGCCTCGATCATGCCTTCGCCAACCGCCGCGCCACCTGCCTGGTCAACCCGCGGGCGGCCTTCGAGACCGAATTGCGCTACCGCAAGGCGCGCACGCAGAAGCGCATCGCGGTGATCGGCGCCGGCCCCGCCGGGCTCTCCGCCGCCTGCGTGGCCGCCGAGCGCGGGCATCGGGTCAGCCTGTTCGAGGCGAGCGGGGAAATCGGCGGGCAGTTCAACCTGGCCAAGCGGATTCCCGGCAAGGAGGAGTTCCGCGAAACCCTGCGCTACTTCCGCGTGCGTCTGGAACGCCTCGGCGTCGACCTGCGCCTCGGCCACCGGGTGCGCCAGGGCGAGCTGGACGGTCAGTTCGACGACGTGGTGGTGGCCACCGGCATCCAGCCACGCCGGCCAAGGATCGACGGCATCGGCGGACCGACCGTACTCAGCTACGTGGACGTGCTGCGCGGCGCGCCGGTGGGCGCGCGGGTCGCCATCGTCGGCGCCGGCGGCATCGGCTTCGACGTCGCCGCCTTCCTCGTCGCCGCGCCCAGCGACGGCCAGCCGCGGGCGCTCGGCGAATGGCTCGCGGAATGGGGCGTGGACCTCGACAACAGCCAGCCCGGCGGTCTCCGCGAACCCGCTCCGACGCGGCCGGCGCGCCAGGTCTGGCTGCTCCAGCGCAAGCCCGGCGCTCCCGGCGCGCAGCTCGGCAAGACCAGCGGCTGGGTACACCGCGCGCACCTCAGGCACAACGCCGTACGGATGCTCGGCGGGGTGGAGTACCTGAAGATCGACGAACGCGGCCTGTTGATCCGCGTCGACGGCGTGGAACGCTGGCTGGAGGTGGACAACGTGGTGATCTGCGCCGGCCAGGAGCCGCTGCGCGAGTTGCAGATCAGACAGGCGACGGAAAGCCTGCGCTTCCACCTGATCGGTGGGGCGCGGGTGGCAGGGGAACTGGATGCCAAGCGGGCGATTCGCGAGGGGGCCATGCTGGCGGCGCGCTTGTAG
    Protein Properties
    Protein Residues: 681
    Protein Molecular Weight: 74.6 kDa
    Protein Theoretical pI: 10.36
    Hydropathicity (GRAVY score): -0.111
    Charge at pH 7 (predicted): 27.34
    Protein Sequence: 
    >PA4814
MRTPYPPLAAAPYPHLLAPLDLGFTRLRNRVVMGSMHTGLEDRLWDFGKLAAYYRERARGGVGLIVTGGFAPCREGWLLPFGSSLTSALEVPAHRRLTQAVHAEGGKILLQILHAGRYGYHPMAVSASPLKSPISWFTPRELSERGIRKTIRAFVRCARLAKAAAYDGVEVMGSEGYLLNQFLCPRTNRRDDQWGGPLENRMRLALEIVRGIRRIVGQRFILCYRLSLLDLVEGGNTWDEVRRIALALEEAGITLLNTGIGWHESRVPTIVTSVPRAAFAEVSARLRHELKVPVIASNRINTPEVAESLLATDKADLVSMARPLLADPQFVAKAGAGRAEEINTCIACNQACLDHAFANRRATCLVNPRAAFETELRYRKARTQKRIAVIGAGPAGLSAACVAAERGHRVSLFEASGEIGGQFNLAKRIPGKEEFRETLRYFRVRLERLGVDLRLGHRVRQGELDGQFDDVVVATGIQPRRPRIDGIGGPTVLSYVDVLRGAPVGARVAIVGAGGIGFDVAAFLVAAPSDGQPRALGEWLAEWGVDLDNSQPGGLREPAPTRPARQVWLLQRKPGAPGAQLGKTSGWVHRAHLRHNAVRMLGGVEYLKIDERGLLIRVDGVERWLEVDNVVICAGQEPLRELQIRQATESLRFHLIGGARVAGELDAKRAIREGAMLAARL
    References
    External Links:
    Resource Link
    Genome ID: PA4814
    Entrez Gene ID: 880156
    NCBI Protein ID: 15600007
    General Reference: PaperBLAST - Find papers about PA4814 and its homologs