Identification
Name: Octaprenyl-diphosphate synthase
Synonyms:
  • Octaprenyl pyrophosphate synthase
  • OPP synthase
Gene Name: ispB
Enzyme Class:
Biological Properties
General Function: Involved in isoprenoid biosynthetic process
Specific Function: Supplies octaprenyl diphosphate, the precursor for the side chain of the isoprenoid quinones ubiquinone and menaquinone
Cellular Location: Not Available
KEGG Pathways:
KEGG Reactions:
Thumb+5 ThumbThumb+5 Thumb
Thumb+5 ThumbThumb+5 Thumb
SMPDB Reactions:
Farnesyl pyrophosphate+5 Isopentenyl pyrophosphate+Thumb+5 Thumb5 Pyrophosphate+Octaprenyl diphosphate+Thumb
Farnesyl pyrophosphate + 5 Isopentenyl pyrophosphate + Farnesyl pyrophosphate + 5 Isopentenyl pyrophosphate → 5 Pyrophosphate + Octaprenyl diphosphate + Octaprenyl diphosphate
ReactionCard
PseudoCyc/BioCyc Reactions:
Thumb+5 ThumbThumb+5 Thumb
Thumb+5 ThumbThumb+5 Thumb
Thumb+5 Thumb5 Thumb+Thumb
Farnesyl pyrophosphate+5 Isopentenyl pyrophosphate+Thumb+5 Thumb5 Pyrophosphate+Octaprenyl diphosphate+Thumb
Farnesyl pyrophosphate + 5 Isopentenyl pyrophosphate + Farnesyl pyrophosphate + 5 Isopentenyl pyrophosphate → 5 Pyrophosphate + Octaprenyl diphosphate + Octaprenyl diphosphate
ReactionCard
Thumb
an all-trans-polyisoprenyl diphosphate + isopentenyl diphosphate = trans-polyisoprenyln+1-PP + diphosphate
ReactionCard
PAMDB110355+PAMDB110165PAMDB110808+PAMDB110246
Complex Reactions:
Thumb+5 Thumb5 Thumb+Thumb
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB000210Farnesyl pyrophosphateMetaboCard
PAMDB000348Isopentenyl pyrophosphateMetaboCard
PAMDB000251Octaprenyl diphosphateMetaboCard
PAMDB000633PyrophosphateMetaboCard
GO Classification:
Process
cellular lipid metabolic process
isoprenoid biosynthetic process
isoprenoid metabolic process
lipid metabolic process
metabolic process
primary metabolic process
Gene Properties
Locus tag: PA4569
Strand: +
Entrez Gene ID: 880946
Accession: NP_253259.1
GI: 15599765
Sequence start: 5116865
Sequence End: 5117833
Sequence Length: 968
Gene Sequence:
>PA4569
ATGCAACCCCAGGCCTTCTACCGCGTGGTGGCGGAAGATTTCACCGCCGTCGACGGGATCATCCGTCGCCAACTCACCTCCCGCGTTCCCCTGGTGGAAAAGATCGGCGACTACATCATCTCCGCCGGCGGCAAGCGCCTGCGTCCGCTGCTGGTCCTGCTCGCCGGCAAGACCCTGGGCTACAAGGGCGACGACCTCTGCCTGCTGGCCGCCACCATCGAATTCCTGCACACCTCCACTCTGCTGCACGACGACGTCGTCGACGCCTCCGGCCTGCGCCGCGGCCGCTCCACCGCCAATGCCCTGTGGGGCAACGCGCCGAGCGTGCTGGTAGGCGACTTCCTTTATGCCCGCTCCTTCGAAATGATGGTCGAGCTGGGTTCCATGCCGGTCATGCGCATCATATCCCAGGCCACCCGGGTGATCGCCGAGGGCGAAGTGCTGCAATTGTCCAAGGTACGCGACGCCAGCACTACCGAAGAGACCTACATGGAAGTGATCCGCGGCAAGACCGCGATGCTTTTCGAGGCCTCGACCCACAGCGCCGCCGCGCTGTGCCAGGCCGGCGAGGAACAGTCCGAGGCACTGCGCCGCTTCGGCGACTACCTGGGAATCGCCTTCCAGCTGGTGGACGACCTGCTCGACTACCGCGGCGACGCCGCGACCCTCGGCAAGAACGTCGGCGACGACCTCGCCGAAGGCAAGCCCACCCTGCCGCTGATCGTCACCATGCGCGACGGCACCGAGGAACAGGCCGCGCTGGTACGCAAAGCCATCCAGCAAGGTGGCAGCCAGGACCTGGAGAGCGTCTGTGCCGCCGTCGAGGCAGCCGGCGCCCTGGACTATACCGCCAACCTCGCCCGCGACTACGCCGCCCGCGCCATCGCCTGCCTGGATACGCTGCCGGACAACGAATACCGCTCCGCCCTGGTCGAACTCAGCGAATTCGCTGTCGCCCGAACCCACTGA
Protein Properties
Protein Residues: 322
Protein Molecular Weight: 34.9 kDa
Protein Theoretical pI: 4.61
Hydropathicity (GRAVY score): 0.031
Charge at pH 7 (predicted): -12.15
Protein Sequence:
>PA4569
MQPQAFYRVVAEDFTAVDGIIRRQLTSRVPLVEKIGDYIISAGGKRLRPLLVLLAGKTLGYKGDDLCLLAATIEFLHTSTLLHDDVVDASGLRRGRSTANALWGNAPSVLVGDFLYARSFEMMVELGSMPVMRIISQATRVIAEGEVLQLSKVRDASTTEETYMEVIRGKTAMLFEASTHSAAALCQAGEEQSEALRRFGDYLGIAFQLVDDLLDYRGDAATLGKNVGDDLAEGKPTLPLIVTMRDGTEEQAALVRKAIQQGGSQDLESVCAAVEAAGALDYTANLARDYAARAIACLDTLPDNEYRSALVELSEFAVARTH
References
External Links:
Resource Link
Genome ID: PA4569
Entrez Gene ID: 880946
NCBI Protein ID: 15599765
General Reference: PaperBLAST - Find papers about PA4569 and its homologs