GTP cyclohydrolase-2 (PA4047)

Identification
Name: GTP cyclohydrolase-2
Synonyms:
  • GTP cyclohydrolase II
Gene Name: ribA
Enzyme Class:
Biological Properties
General Function: Involved in GTP cyclohydrolase II activity
Specific Function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate
Cellular Location: Cytoplasmic
KEGG Pathways:
KEGG Reactions:
Thumb+3 Thumb ↔ Thumb+Thumb+2 Thumb+Thumb+Thumb
Guanosine triphosphate + 3 Water ↔ 2,5-Diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine + Formic acid + 2 Hydrogen ion + Pyrophosphate + 2,5-diamino-6-hydroxy-4-(5-phospho-D-ribosylamino)pyrimidine
ReactionCard
Thumb+3 Thumb ↔ Thumb+Thumb+Thumb
Guanosine triphosphate + 3 Water ↔ Formic acid + 2,5-Diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine + Pyrophosphate
ReactionCard
SMPDB Reactions: Not Available
PseudoCyc/BioCyc Reactions:
Thumb+3 Thumb ↔ Thumb+Thumb+2 Thumb+Thumb+Thumb
Guanosine triphosphate + 3 Water ↔ 2,5-Diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine + Formic acid + 2 Hydrogen ion + Pyrophosphate + 2,5-diamino-6-hydroxy-4-(5-phospho-D-ribosylamino)pyrimidine
ReactionCard
Complex Reactions:
Thumb+3 Thumb → Thumb+Thumb+Thumb
Guanosine triphosphate + 3 Water → Formic acid + 2,5-Diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine + Pyrophosphate
ReactionCard
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB0005842,5-Diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidineMetaboCard
PAMDB000053Formic acidMetaboCard
PAMDB000319Guanosine triphosphateMetaboCard
PAMDB001633Hydrogen ionMetaboCard
PAMDB000633PyrophosphateMetaboCard
PAMDB000142WaterMetaboCard
GO Classification:
Function
catalytic activity
cyclohydrolase activity
GTP cyclohydrolase activity
GTP cyclohydrolase II activity
hydrolase activity
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
Process
metabolic process
nitrogen compound metabolic process
riboflavin biosynthetic process
riboflavin metabolic process
Gene Properties
Locus tag: PA4047
Strand: -
Entrez Gene ID: 879059
Accession: NP_252736.1
GI: 15599242
Sequence start: 4529995
Sequence End: 4530612
Sequence Length: 617
Gene Sequence: 
>PA4047
GTGTCCGTCGTGTTCGTCGCCGCCTCCAAACTGCCGACTCCCTTCGGCGAATTCACCATGCATGGTTTCCTCGACGAGGAGAGCGGCAAGGAACATGTAGCCCTGAGCATGGGCGACATCGCCGATGGCGCGCCGGTGCTTGGTCGCCTGCATTCCGAATGCCTGACCGGCGACGCGCTGTTCAGCCTGCGCTGCGATTGCGGTTTCCAGCTGGAAGGCGCGCTTGCCGCCATCGCCGAGGAGGGCCGCGGCGTGCTCCTCTACCTGCGCCAGGAAGGTCGCGGCATCGGCCTGCTGAACAAGATCCGTGCCTATGAATTGCAGGATGGCGGTGCCGACACCGTCGAGGCGAACCTGCAACTGGGTTTTGGCGCCGACCAGCGCGACTACGCCATGTGCCAGCCGATGCTCGCGCACCTGGGCGTCTCCTCCCTGCGCCTGATGACCAACAATCCGCGCAAGGTCAAGGCGCTGGAAAGCTACGCCATCACCGTGGCGGAGCGCGTGCCGCTGCAAAAGGGCCTGAACAAGCACAACAGGCGCTACCTGGCGACCAAGGCCGGCAAGCTCGGGCACATGCTCGGCAGCCTGCACCAGGGCGAGGCGGAAACCACGTGA
Protein Properties
Protein Residues: 205
Protein Molecular Weight: 22.1 kDa
Protein Theoretical pI: 6.63
Hydropathicity (GRAVY score): -0.101
Charge at pH 7 (predicted): -1.44
Protein Sequence: 
>PA4047
MSVVFVAASKLPTPFGEFTMHGFLDEESGKEHVALSMGDIADGAPVLGRLHSECLTGDALFSLRCDCGFQLEGALAAIAEEGRGVLLYLRQEGRGIGLLNKIRAYELQDGGADTVEANLQLGFGADQRDYAMCQPMLAHLGVSSLRLMTNNPRKVKALESYAITVAERVPLQKGLNKHNRRYLATKAGKLGHMLGSLHQGEAETT
References
External Links:
Resource Link
Genome ID: PA4047
Entrez Gene ID: 879059
NCBI Protein ID: 15599242
General Reference: PaperBLAST - Find papers about PA4047 and its homologs