Gamma-glutamyl phosphate reductase (PA4007)

Identification
Name: Gamma-glutamyl phosphate reductase
Synonyms:
  • GPR
  • Glutamate-5-semialdehyde dehydrogenase
  • Glutamyl-gamma-semialdehyde dehydrogenase
  • GSA dehydrogenase
Gene Name: proA
Enzyme Class:
Biological Properties
General Function: Involved in oxidoreductase activity
Specific Function: Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate
Cellular Location: Cytoplasm
KEGG Pathways:
KEGG Reactions:
Thumb+Thumb+Thumb ↔ L-Glutamyl 5-phosphate+Thumb+Thumb+Thumb
L-Glutamic-gamma-semialdehyde + Phosphate + NADP ↔ L-Glutamyl 5-phosphate + NADPH + Hydrogen ion + L-Glutamic acid 5-phosphate
ReactionCard
SMPDB Reactions:
Thumb+Thumb+NADPH+Thumb → Thumb+Thumb+Thumb
L-Glutamic acid 5-phosphate + Hydrogen ion + NADPH + NADPH → L-Glutamic-gamma-semialdehyde + NADP + Phosphate
ReactionCard
PseudoCyc/BioCyc Reactions:
Thumb+Thumb+Thumb → Thumb+Thumb+Thumb
L-Glutamic acid 5-phosphate + Hydrogen ion + NADPH → L-Glutamic-gamma-semialdehyde + NADP + Phosphate
ReactionCard
Complex Reactions:
Thumb+Thumb+Thumb → Thumb+Thumb
L-Glutamic-gamma-semialdehyde + Inorganic phosphate + NADP → L-Glutamic acid 5-phosphate + NADPH
ReactionCard
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB001633Hydrogen ionMetaboCard
PAMDB001776Inorganic phosphateMetaboCard
PAMDB000304L-Glutamic acid 5-phosphateMetaboCard
PAMDB000331L-Glutamic-gamma-semialdehydeMetaboCard
PAMDB000089NADPMetaboCard
PAMDB000615NADPHMetaboCard
PAMDB000383PhosphateMetaboCard
PAMDB000187Pyrrolidonecarboxylic acidMetaboCard
GO Classification:
Function
binding
catalytic activity
glutamate-5-semialdehyde dehydrogenase activity
NADP or NADPH binding
nucleotide binding
oxidoreductase activity
oxidoreductase activity, acting on the aldehyde or oxo group of donors
oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
Process
cellular amino acid and derivative metabolic process
cellular amino acid metabolic process
cellular metabolic process
glutamine family amino acid metabolic process
metabolic process
oxidation reduction
proline biosynthetic process
proline metabolic process
Gene Properties
Locus tag: PA4007
Strand: -
Entrez Gene ID: 878970
Accession: NP_252696.1
GI: 15599202
Sequence start: 4486847
Sequence End: 4488112
Sequence Length: 1265
Gene Sequence: 
>PA4007
ATGACCGAGTCCGTCCTCGACTATATGAGCCGCCTTGGCCGCGATGCCCGCGCCGCCTCGCGGTTGCTCGCGCGCGCCGCCACCGCGCAGAAGAACCGCGCCCTGCTGGCCGCGGCCGATGCGCTGGACGCCGCCCGCGCGGAGTTGTCCCACGCCAACGAGCAGGACCTCGCCGCCGGCCGCGCCAATGGCCTGGAGCCGGCGATGCTGGACCGCCTGGCGCTGACCCCGGCGCGCATCGACGACATGATCGAGGGCCTGCGCCAGGTCGCCACGCTGCCCGACCCGATCGGCGAGATCCGCGACATGCGCTATGTGCCCTCGGGCATCCAGATCGGCAAGATGCGCGTGCCGCTGGGCGTGGTCGGGATCATCTACGAGTCGCGGCCGAACGTGACCATCGACGCCGCCAGCCTGTGCCTGAAGTCCGGCAACGCGACCATCCTGCGCGGCGGCTCCGAGGCGATCCACTCCAACCAGGCGATCGCCCGCTGCATCCAGCAGGGCCTGGCCGAGGCCGGCCTGCCGGCCGCCGCCGTGCAGGTGGTGGAAACCACCGACCGCGCGGCGGTCGGCGCGCTGATCAGCATGCCCGAATACGTCGACGTGATCGTCCCGCGCGGCGGCAAGGGCCTGATCGAGCGCATCAGCCGCGAGGCCAAGGTGCCGGTGATCAAGCACCTGGACGGCATCTGCCACGTCTACATCGATGTCGCCGCCGACCTGGACAAGGCGATTCGCGTCGCCGACAACGCCAAGACCCAGCGCTACGCGCCGTGCAACACCATGGAGACGCTGCTGGTGCATGCCGGTATCGCCGAGCGGGTGCTGCCGCCGCTGGCCACGATCTACCGCGAGAAGGGCGTGGAACTGCGCGGCGACGCCGCGACCCGCGCGCTGCTCGGCGCAGACGTGCTGGAGGCTACCGAGGAGGACTGGCGTACCGAGTACAACGCGCCGATCCTGTCGATCCGCATCGTCGACGGGCTGGACGCGGCGATCGAGCACATCAACACCTACGGCTCGCAGCACACCGACGCGATCATTACCGAGAACTTCAGCGATGCGCGGCGTTTCCTCGCCGAAGTGGATTCCGCTTCGGTGATGGTCAACGCCTCGACCCGCTTCGCCGACGGCTTCGAGTACGGCCTCGGCGCCGAGATCGGGATTTCCACCGACAAGCTGCACGCCCGCGGCCCGGTCGGCCTGGAAGGCCTGACCAGCGAGAAGTACGTCGTCTTCGGCGACGGTCACGTGCGCACCTGA
Protein Properties
Protein Residues: 421
Protein Molecular Weight: 45 kDa
Protein Theoretical pI: 5.2
Hydropathicity (GRAVY score): -0.015
Charge at pH 7 (predicted): -9.94
Protein Sequence: 
>PA4007
MTESVLDYMSRLGRDARAASRLLARAATAQKNRALLAAADALDAARAELSHANEQDLAAGRANGLEPAMLDRLALTPARIDDMIEGLRQVATLPDPIGEIRDMRYVPSGIQIGKMRVPLGVVGIIYESRPNVTIDAASLCLKSGNATILRGGSEAIHSNQAIARCIQQGLAEAGLPAAAVQVVETTDRAAVGALISMPEYVDVIVPRGGKGLIERISREAKVPVIKHLDGICHVYIDVAADLDKAIRVADNAKTQRYAPCNTMETLLVHAGIAERVLPPLATIYREKGVELRGDAATRALLGADVLEATEEDWRTEYNAPILSIRIVDGLDAAIEHINTYGSQHTDAIITENFSDARRFLAEVDSASVMVNASTRFADGFEYGLGAEIGISTDKLHARGPVGLEGLTSEKYVVFGDGHVRT
References
External Links:
Resource Link
Genome ID: PA4007
Entrez Gene ID: 878970
NCBI Protein ID: 15599202
General Reference: PaperBLAST - Find papers about PA4007 and its homologs